The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Impaired cytoadherence of Plasmodium falciparum -infected erythrocytes containing sickle hemoglobin
Open accessAbstract
Sickle trait, the heterozygous state of normal hemoglobin A (HbA) and sickle hemoglobin S (HbS), confers protection against malaria in Africa. AS children infected with Plasmodium falciparum are less likely than AA children to suffer the symptoms or severe manifestations of malaria, and they often carry lower parasite densities than AA children. The mechanisms by which sickle trait might confer such malaria protection remain unclear. We have compared the cytoadherence properties of parasitized AS and AA erythrocytes, because it is by these properties that parasitized erythrocytes can sequester in postcapillary microvessels of critical tissues such as the brain and cause the life-threatening complications of malaria. Our results show that the binding of parasitized AS erythrocytes to microvascular endothelial cells and blood monocytes is significantly reduced relative to the binding of parasitized AA erythrocytes. Reduced binding correlates with the altered display of P. falciparum erythrocyte membrane protein-1 (PfEMP-1), the parasite's major cytoadherence ligand and virulence factor on the erythrocyte surface. These findings identify a mechanism of protection for HbS that has features in common with that of hemoglobin C (HbC). Coinherited hemoglobin polymorphisms and naturally acquired antibodies to PfEMP-1 may influence the degree of malaria protection in AS children by further weakening cytoadherence interactions.
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“As a consequence, the balance between damaging prooxidative molecules such as free heme or iron and antioxidative factors such as carbon monoxide (CO) and bilirubin is shifted towards cytoprotection (Cholera et al., 2008;Ferreira et al., 2011;Gong et al., 2013;Jeney et al., 2014).”
From Iron in infection and immunity (2020) · cites this paper as Cholera et al., 2008
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Cites
The pathogenic basis of malaria
Miller, L. H., Baruch, D. I., Marsh, K., & Doumbo, O. K. (2002) · Nature · doi:10.1038/415673a · Cited by 1,804
Self-citationCommon West African HLA antigens are associated with protection from severe malaria
Hill, A. V. S., Allsopp, C. E. M., Kwiatkowski, D. P., Anstey, N. M., Twumasi, P., Rowe, P. A., Bennett, S., Brewster, D., McMichael, A. J., & Greenwood, B. M. (1991) · Nature · doi:10.1038/352595a0 · Cited by 1,573
Protection Afforded by Sickle-cell Trait Against Subtertian Malarial Infection
ALLISON, A. C. (1954) · BMJ · doi:10.1136/bmj.1.4857.290 · Cited by 1,297
Su, X.-Z., Heatwole, V. M., Wertheimer, S. P., Guinet, F., Herrfeldt, J. A., Peterson, D. S., Ravetch, J. A., & Wellems, T. E. (1995) · Cell · doi:10.1016/0092-8674(95)90055-1 · Cited by 1,219
Self-citationBaruch, D., Pasloske, B., Singh, H. B., Bi, X., Ma, X. C., Feldman, M., Taraschi, T., & Howard, R. J. (1995) · Cell · doi:10.1016/0092-8674(95)90054-3 · Cited by 1,087
Smith, J. D., Chitnis, C. E., Craig, A. G., Roberts, D. J., Hudson-Taylor, D. E., Peterson, D. S., Pinches, R., Newbold, C. I., & Miller, L. H. (1995) · Cell · doi:10.1016/0092-8674(95)90056-x · Cited by 1,005
Tumor Necrosis Factor and Disease Severity in Children with Falciparum Malaria
Grau, G. E., Taylor, T. E., Molyneux, M. E., Wirima, J. J., VASSALLI, P., Hommel, M., & Lambert, P. (1989) · New England Journal of Medicine · doi:10.1056/nejm198906153202404 · Cited by 839
MacPherson, G. G., Warrell, M. J., White, N. J., Looareesuwan, S., & Warrell, D. A. (1985) · PubMed Central · Cited by 825
Protective effects of the sickle cell gene against malaria morbidity and mortality
Aidoo, M., Terlouw, D. J., KOLCZAK, M. S., McElroy, P. D., ter Kuile, F. O., Kariuki, S., Nahlen, B. L., Lal, A. A., & Udhayakumar, V. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08273-9 · Cited by 701
Turner, G. D. H., Morrison, H., Jones, M., Davis, T. M. E., Looareesuwan, S., BULEY, I. D., Gatter, K. C., Newbold, C., Pukritayakamee, S., & Nagachinta, B. (1994) · PubMed Central · Cited by 596
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Phillips, M. A., Burrows, J. N., Manyando, C., van Huijsduijnen, R. H., Voorhis, W. C. V., & Wells, T. N. C. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.50 · Cited by 681
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Williams, T. N., & Weatherall, D. J. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a011692 · Cited by 448
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Metadata
- Authors
- Cholera, R., Brittain, N. J., Gillrie, M. R., Lopera-Mesa, T. M., Diakité, S. A. S., Arie, T., Krause, M. A., Guindo, A., Tubman, A., Fujioka, H., Diallo, D. A., Doumbo, O. K., Ho, M., Wellems, T. E., & Fairhurst, R. M.
- Affiliations
- National Institutes of Health (US)
- University of Calgary (CA)
- Malaria Research and Training Center, Faculty of Medicine, Pharmacy, and Odontostomatology, University of Bamako, Bamako, BP 1805, Mali; and
- University of Bamako (ML)
- Case Western Reserve University (US)
- Corresponding author
- Wellems, Thomas E.
- Fairhurst, Rick M.
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2008-01-22
- Volume
- 105
- Issue
- 3
- Pages
- 991-996
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2242681
- OpenAlex
- W2111913495
- Cited by
- 249
- References
- 45
- Citations by year
- 2026: 10 · 2025: 6 · 2024: 3 · 2023: 14 · 2022: 7 · 2021: 15 · 2020: 16 · 2019: 16 · 2018: 8 · 2017: 11 · 2016: 16 · 2015: 14 · 2014: 16 · 2013: 19 · 2012: 18
- FWCI
- 19.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Health Sciences › Medicine › Genetics (clinical) › Hemoglobinopathies and Related Disorders
- Health Sciences › Medicine › Hematology › Blood groups and transfusion
- Keywords
- sickle cell trait, hemoglobin S, Plasmodium falciparum, cytoadherence, malaria prevention, PfEMP1, erythrocyte membrane protein 1, hemoglobin C, endothelial cell adhesion, monocyte adhesion, naturally acquired antibodies, hemoglobin polymorphism, children
- MeSH terms
- Animals, Cell Adhesion, Cells, Cultured, Erythrocytes, Hemoglobin SC Disease, Hemoglobin, Sickle, Humans, Microcirculation, Monocytes, Plasmodium falciparum, Sickle Cell Trait, Protozoan Proteins, Endothelial Cells, Microscopy, Electron, Transmission
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