CoChat
Sign Up
Cited by 116Cannabis and Cannabinoid ResearchNeuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.

Interneuron activity controls endocannabinoid-mediated presynaptic plasticity through calcineurin

Open access
Heifets, Boris D., Chevaleyre, Vivien, Castillo, Pablo E.·2008·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.0711880105PMC PMC2481322
Open this paper in CoChat — free account

Abstract

Retrograde signaling by endocannabinoids (eCBs) mediates a widely expressed form of long-term depression at excitatory and inhibitory synapses (eCB-LTD), involving a reduction in neurotransmitter release. In the hippocampus, eCB-LTD occurs at interneuron (IN)-pyramidal cell (PC) synapses (I-LTD), and its induction requires a presynaptic reduction of cAMP/PKA signaling resulting from minutes of type 1 cannabinoid receptor (CB1R) activation. Although repetitive activity of glutamatergic synapses initiates the eCB mobilization required for I-LTD, it is unclear whether CB1R-containing GABAergic terminals are passive targets of eCBs or whether they actively contribute to induction. Here, we show that the minutes-long induction period for I-LTD may serve as a window to integrate associated spontaneous activity in the same IN receiving the retrograde eCB signal. Indeed, reducing spontaneous IN firing blocked I-LTD, which could be rescued with extra stimulation of inhibitory afferents. Moreover, cell pair recordings showed that a single IN expressed LTD onto a PC only if it was active during eCB signaling. Several methods of disrupting presynaptic Ca(2+) dynamics all blocked I-LTD, strongly suggesting that IN spikes regulate I-LTD by raising Ca(2+) at the nerve terminal. Finally, inhibiting the Ca(2+)-activated phosphatase, calcineurin, fully blocked I-LTD, but blocking another phosphatase did not. Our findings support a model where both CB1R signaling and IN activity shift the balance of kinase and phosphatase activity in the presynaptic terminal to induce I-LTD.

Overview

Integrity signals

Registry

Crossref · 10.1073/pnas.0711880105

Cites

47 of 47 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 47 references

Research works printed but not linked: 1

  1. 10.1042/BST0331345 · DOI

Cited by

Sorted by citations

Items 101–116 of 116

Related

See all

Metadata

Authors
Heifets, B. D., Chevaleyre, V., & Castillo, P. E.
Affiliations
Albert Einstein College of Medicine (US)
ORCID
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2008-07-22
Volume
105
Issue
29
Pages
10250-10255
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.0711880105
PMC
PMC2481322
OpenAlex
W2040301525
Cited by
116
References
47
Citations by year
2026: 1 · 2025: 5 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 7 · 2020: 7 · 2019: 2 · 2018: 6 · 2017: 7 · 2016: 8 · 2015: 5 · 2014: 9 · 2013: 11 · 2012: 6
FWCI
7.97
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Alliance for Research on Schizophrenia and Depression
  • National Institutes of Health
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
presynaptic plasticity, calcineurin, CB1 receptor, hippocampus, cAMP/PKA signaling, phosphatase activity
MeSH terms
Animals, Electric Stimulation, Electrophysiology, Hippocampus, Interneurons, Neuronal Plasticity, Tetrodotoxin, Signal Transduction, Rats, Sprague-Dawley, Pyramidal Cells, Patch-Clamp Techniques, Calcineurin, Calcium Signaling, Long-Term Synaptic Depression, Receptor, Cannabinoid, CB1, Rats, Cannabinoid Receptor Modulators, Endocannabinoids, Calcineurin Inhibitors, In Vitro Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review