The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Dynamics of Pseudomonas aeruginosa genome evolution
Open accessAbstract
One of the hallmarks of the Gram-negative bacterium Pseudomonas aeruginosa is its ability to thrive in diverse environments that includes humans with a variety of debilitating diseases or immune deficiencies. Here we report the complete sequence and comparative analysis of the genomes of two representative P. aeruginosa strains isolated from cystic fibrosis (CF) patients whose genetic disorder predisposes them to infections by this pathogen. The comparison of the genomes of the two CF strains with those of other P. aeruginosa presents a picture of a mosaic genome, consisting of a conserved core component, interrupted in each strain by combinations of specific blocks of genes. These strain-specific segments of the genome are found in limited chromosomal locations, referred to as regions of genomic plasticity. The ability of P. aeruginosa to shape its genomic composition to favor survival in the widest range of environmental reservoirs, with corresponding enhancement of its metabolic capacity is supported by the identification of a genomic island in one of the sequenced CF isolates, encoding enzymes capable of degrading terpenoids produced by trees. This work suggests that niche adaptation is a major evolutionary force influencing the composition of bacterial genomes. Unlike genome reduction seen in host-adapted bacterial pathogens, the genetic capacity of P. aeruginosa is determined by the ability of individual strains to acquire or discard genomic segments, giving rise to strains with customized genomic repertoires. Consequently, this organism can survive in a wide range of environmental reservoirs that can serve as sources of the infecting organisms.
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Cites
Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen
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Self-citationLung Infections Associated with Cystic Fibrosis
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Genetic adaptation by Pseudomonas aeruginosa to the airways of cystic fibrosis patients
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Comprehensive transposon mutant library of Pseudomonas aeruginosa
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An ordered, nonredundant library of Pseudomonas aeruginosa strain PA14 transposon insertion mutants
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Genetic Recombination in Pseudomonas aeruginosa
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Genomic analysis reveals that Pseudomonas aeruginosa virulence is combinatorial
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Cited by
Pseudomonas aeruginosa Lifestyle: A Paradigm for Adaptation, Survival, and Persistence
Moradali, M. F., Ghods, S., & Rehm, B. H. A. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00039 · Cited by 1,537
Pseudomonas aeruginosa : new insights into pathogenesis and host defenses
Gellatly, S. L., & Hancock, R. E. W. (2013) · Pathogens and Disease · doi:10.1111/2049-632x.12033 · Cited by 1,295
Winsor, G. L., Griffiths, E. J., Lo, R., Dhillon, B. K., Shay, J. A., & Brinkman, F. S. L. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkv1227 · Cited by 1,050
Non-tuberculous mycobacteria and the rise of Mycobacterium abscessus
Johansen, M. D., Herrmann, J.-L., & Kremer, L. (2020) · Nature Reviews Microbiology · doi:10.1038/s41579-020-0331-1 · Cited by 822
Comparative Genome Sequence Analysis of Multidrug-Resistant Acinetobacter baumannii
Adams, M. D., Goglin, K., Molyneaux, N., Hujer, K. M., Lavender, H., Jamison, J. J., MacDonald, I. J., Martin, K. M., Russo, T., Campagnari, A. A., et al. (2008) · Journal of Bacteriology · doi:10.1128/jb.00834-08 · Cited by 435
Metadata
- Authors
- Mathee, K., Narasimhan, G., Valdes, C., Qiu, X., Matewish, J. M., Koehrsen, M., Rokas, A., Yandava, C. N., Engels, R., Zeng, E., Olavarietta, R., Doud, M., Smith, R. S., Montgomery, P., White, J. R., Godfrey, P. A., Kodira, C., Birren, B., Galagan, J. E., & Lory, S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2008-02-26
- Volume
- 105
- Issue
- 8
- Pages
- 3100-3105
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2036335453
- Cited by
- 494
- References
- 21
- FWCI
- 13.28
- Type
- journal article
- Language
- en
- Open access
- green
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- Mathee, K., Narasimhan, G., Valdes, C., Qiu, X., Matewish, J. M., Koehrsen, M., Rokas, A., Yandava, C. N., Engels, R., Zeng, E., Olavarietta, R., Doud, M., Smith, R. S., Montgomery, P., White, J. R., Godfrey, P. A., Kodira, C., Birren, B., Galagan, J. E., & Lory, S. (2008). Dynamics of Pseudomonas aeruginosa genome evolution. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0711982105
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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