The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Identification of a small molecule inhibitor of the hedgehog signaling pathway: Effects on basal cell carcinoma-like lesions
Open accessAbstract
The link between basal cell carcinoma (BCC) and aberrant activation of the Hedgehog (Hh) signaling pathway has been well established in humans and in mouse models. Here we report the development of assays, including two novel in vitro BCC models, which allowed us to screen for Hh inhibitors and test their validity as potential treatments for BCC. We identified a novel small molecule Hh inhibitor (CUR61414) that can block elevated Hh signaling activity resulting from oncogenic mutations in Patched-1. Moreover, CUR61414 can suppress proliferation and induce apoptosis of basaloid nests in the BCC model systems, whereas having no effect on normal skin cells. These findings directly demonstrate that the use of Hh inhibitors could be a valid therapeutic approach for treating BCC.
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Citations
Cites
Teratogen-Mediated Inhibition of Target Tissue Response to Shh Signaling
Cooper, M. K., Porter, J. A., Young, K. E., & Beachy, P. A. (1998) · Science · doi:10.1126/science.280.5369.1603 · Cited by 848
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Cited by
Tissue repair and stem cell renewal in carcinogenesis
Beachy, P. A., Karhadkar, S. S., & Berman, D. M. (2004) · Nature · doi:10.1038/nature03100 · Cited by 1,208
Hedgehog signalling in cancer formation and maintenance
di Magliano, M. P., & Hebrok, M. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1229 · Cited by 829
Romer, J. T., Kimura, H., Magdaleno, S., Sasai, K., Fuller, C., Baines, H., Connelly, M., Stewart, C. F., Gould, S., Rubin, L. L., et al. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.08.019 · Cited by 522
Self-citationThe Hedgehog's tale: developing strategies for targeting cancer
Ng, J. M. Y., & Curran, T. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3079 · Cited by 398
GDC-0449—A potent inhibitor of the hedgehog pathway
Robarge, K. D., Brunton, S. A., Castanedo, G. M., Cui, Y., Dina, M. S., Goldsmith, R., Gould, S. E., Guichert, O., Gunzner, J. L., Halladay, J., et al. (2009) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2009.08.049 · Cited by 386
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Metadata
- Authors
- Williams, J. A., Guicherit, O. M., Zaharian, B. I., Xu, Y., Chai, L., Wichterle, H., Kon, C., Gatchalian, C., Porter, J. A., Rubin, L. L., & Wang, F. Y.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2003-04-04
- Volume
- 100
- Issue
- 8
- Pages
- 4616-4621
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2115399432
- Cited by
- 299
- References
- 1
- FWCI
- 6.65
- Type
- journal article
- Language
- en
- Open access
- green
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- Williams, J. A., Guicherit, O. M., Zaharian, B. I., Xu, Y., Chai, L., Wichterle, H., Kon, C., Gatchalian, C., Porter, J. A., Rubin, L. L., & Wang, F. Y. (2003). Identification of a small molecule inhibitor of the hedgehog signaling pathway: Effects on basal cell carcinoma-like lesions. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0732813100
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