The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
TRPA1 regulates gastrointestinal motility through serotonin release from enterochromaffin cells
Open accessAbstract
Serotonin (5-hydroxytryptamine; 5-HT) is abundantly present throughout the gastrointestinal tract and stored mostly in enterochromaffin (EC) cells, which are located on the mucosal surface. 5-HT released from EC cells stimulate both intrinsic and extrinsic nerves, which results in various physiological and pathophysiological responses, such as gastrointestinal contractions. EC cells are believed to have the ability to respond to the chemical composition of the luminal contents of the gut; however, the underlying molecular and cellular mechanisms have not been identified. Here, we demonstrate that the transient receptor potential (TRP) cation channel TRPA1, which is activated by pungent compounds or cold temperature, is highly expressed in EC cells. We also found that TRPA1 agonists, including allyl isothiocyanate and cinnamaldehyde, stimulate EC cell functions, such as increasing intracellular Ca 2+ levels and 5-HT release, by using highly concentrated EC cell fractions and a model of EC cell function, the RIN14B cell line. Furthermore, we showed that allyl isothiocyanate promotes the contraction of isolated guinea pig ileum via the 5-HT 3 receptor. Taken together, our results indicate that TRPA1 acts as a sensor molecule for EC cells and may regulate gastrointestinal function.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“TRPA1 can promote serotonin release from enterochromaffin cells and subsequently increase colonic peristalsis and tone [35, 36].”
From The effects of ginger supplementation on common gastrointestinal symptoms in patients with relapsing-remitting multiple sclerosis: a double-blind randomized placebo-controlled trial (2023) · cites this paper as [35]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The capsaicin receptor: a heat-activated ion channel in the pain pathway
Caterina, M. J., Schumacher, M. A., Tominaga, M., Rosen, T. A., Levine, J. D., & Julius, D. J. (1997) · Nature · doi:10.1038/39807 · Cited by 9,132
ANKTM1, a TRP-like Channel Expressed in Nociceptive Neurons, Is Activated by Cold Temperatures
Story, G. M., Peier, A. M., Reeve, A. J., Eid, S. R., Mosbacher, J., Hricik, T., Earley, T. J., Hergarden, A. C., Andersson, D. A., Hwang, S. W., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00158-2 · Cited by 2,494
A TRP Channel that Senses Cold Stimuli and Menthol
Peier, A. M., Moqrich, A., Hergarden, A. C., Reeve, A. J., Andersson, D. A., Story, G. M., Earley, T. J., Dragoni, I., McIntyre, P., Bevan, S., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)00652-9 · Cited by 2,361
TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic Agents
Bautista, D. M., Jordt, S. E., Nikai, T., Tsuruda, P. R., Read, A. J., Poblete, J., Yamoah, E. N., Basbaum, A. I., & Julius, D. J. (2006) · Cell · doi:10.1016/j.cell.2006.02.023 · Cited by 1,921
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
Jordt, S., Bautista, D. M., Chuang, H.-H., McKemy, D. D., Zygmunt, P. M., Högestätt, E. D., Meng, I. D., & Julius, D. J. (2004) · Nature · doi:10.1038/nature02282 · Cited by 1,896
Noxious Cold Ion Channel TRPA1 Is Activated by Pungent Compounds and Bradykinin
Bandell, M., Story, G. M., Hwang, S. W., Viswanath, V., Eid, S. R., Petrus, M. J., Earley, T. J., & Patapoutian, A. (2004) · Neuron · doi:10.1016/s0896-6273(04)00150-3 · Cited by 1,822
Gershon, M. D., & Tack, J. (2007) · Gastroenterology · doi:10.1053/j.gastro.2006.11.002 · Cited by 1,563
Kwan, K. Y., Allchorne, A. J., Vollrath, M. A., Christensen, A. P., Zhang, D.-S., Woolf, C. J., & Corey, D. P. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.042 · Cited by 1,267
Pungent products from garlic activate the sensory ion channel TRPA1
Bautista, D. M., Movahed, P., Hinman, A., Axelsson, H. E., Sterner, O., Högestätt, E. D., Julius, D. J., Jordt, S., & Zygmunt, P. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505356102 · Cited by 863
Nociceptor and Hair Cell Transducer Properties of TRPA1, a Channel for Pain and Hearing
Nagata, K., Duggan, A., Kumar, G., & Garcı́a-Añoveros, J. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0013-05.2005 · Cited by 646
Cited by
Sorted by citations
Items 101–200 of 413
Activation of TRPA1 by luminal stimuli induces EP4-mediated anion secretion in human and rat colon
Kaji, I., Yasuoka, Y., Karaki, S.-I., & Kuwahara, A. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00289.2011 · Cited by 55
Rooney, L., Vidal, A., D’Souza, A.-M., Devereux, N., Masick, B. T., Boissel, V., West, R., Head, V., Stringer, R. A., Lao, J., et al. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm401986p · Cited by 54
Jiang, L., Gamper, N. L., & Beech, D. J. (2011) · Current Drug Targets · doi:10.2174/138945011795378568 · Cited by 53
Effects of luminal thymol on epithelial transport in human and rat colon
Kaji, I., Karaki, S.-I., & Kuwahara, A. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00503.2010 · Cited by 52
The cornucopia of intestinal chemosensory transduction
Bertrand, P. (2009) · Frontiers in Neuroscience · doi:10.3389/neuro.21.003.2009 · Cited by 53
Capasso, R., Aviello, G., Romano, B., Borrelli, F., PETROCELLIS, L. D., Marzo, V. D., & Izzo, A. A. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01703.x · Cited by 51
Revisiting concepts of visceral nociception in irritable bowel syndrome
Keszthelyi, D., Troost, F., Simrén, M., Ludidi, S., Kruimel, J., Conchillo, J., & Masclee, A. (2012) · European Journal of Pain · doi:10.1002/j.1532-2149.2012.00147.x · Cited by 44
Alvarenga, E. M., de Souza, L. K. M., Araújo, T. S. L., Nogueira, K. D. M., Sousa, F. B. M., de Araújo, A. R., Martins, C. S., Pacífico, D. M., Brito, G. A. D. C., de Souza, E. P., et al. (2016) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2016.11.009 · Cited by 51
Sodium channel NaV1.3 is important for enterochromaffin cell excitability and serotonin release
Strege, P., Knutson, K. R., Eggers, S. J., Li, J. H., Wang, F., Linden, D., Szurszewski, J., Milescu, L., Leiter, A., Farrugia, G., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-15834-3 · Cited by 45
Topological segregation of stress sensors along the gut crypt–villus axis
Touhara, K. K., Rossen, N. D., Deng, F., Castro, J., Harrington, A. M., Chu, T., Garcia‐Caraballo, S., Brizuela, M., O’Donnell, T. A., Xu, J., et al. (2025) · Nature · doi:10.1038/s41586-024-08581-9 · Cited by 53
Gut Microbiome Regulation of Gut Hormone Secretion
Chao, J. L., Coleman, R. A., Keating, D. J., & Martin, A. M. (2025) · Endocrinology · doi:10.1210/endocr/bqaf004 · Cited by 60
Waclawiková, B., Bullock, A., Schwalbe, M., Aranzamendi, C., Nelemans, S. A., van Dijk, G., & Aidy, S. E. (2021) · PLoS Biology · doi:10.1371/journal.pbio.3001070 · Cited by 56
Transient receptor potential channels and energy homeostasis
Ahern, G. P. (2013) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2013.06.005 · Cited by 48
Functional foods with digestion-enhancing properties
Valussi, M. (2011) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637486.2011.627841 · Cited by 48
Is TRPA1 Burning Down TRPV1 as Druggable Target for the Treatment of Chronic Pain?
Giorgi, S., Nikolaeva‐Koleva, M., Alarcón-Alarcón, D., Butrón, L., & González‐Rodríguez, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20122906 · Cited by 47
Ulbricht, C. E., Seamon, E., Windsor, R. C., Armbruester, N., Bryan, J. K., Costa, D., Giese, N., Gruenwald, J., Iovin, R. C., Isaac, R., et al. (2011) · Journal of Dietary Supplements · doi:10.3109/19390211.2011.627783 · Cited by 52
Role of Transient Receptor Potential Channels in Intestinal Inflammation and Visceral Pain
Zielińska, M., Jarmuż, A., Wasilewski, A., Sałaga, M., & Fichna, J. (2014) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000234 · Cited by 45
Kojima, R., Doihara, H., Nozawa, K., Kawabata-Shoda, E., Yokoyama, T., & Ito, H. (2009) · Pharmacology · doi:10.1159/000236524 · Cited by 46
Self-citationMottawea, W., Yousuf, B., Sultan, S., Ahmed, T. A., Yeo, J., Hüttmann, N., Li, Y., Bouhlel, N. E., Hassan, H., Zhang, X., et al. (2024) · Microbiology Spectrum · doi:10.1128/spectrum.01368-24 · Cited by 45
Generation and characterization of T1R2-LacZ knock-in mouse
Iwatsuki, K., Nomura, M., Shibata, A., Ichikawa, R., Enciso, P. L. M., Wang, L., Takayanagi, R., Torii, K., & Uneyama, H. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.10.057 · Cited by 42
Tsuruta, T., Saito, S., Osaki, Y., Hamada, A., AOKI-YOSHIDA, A., & Sonoyama, K. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.03.165 · Cited by 42
Feng, C.-C., Yan, X.-J., Chen, X., Wang, E.-M., Liu, Q. H., Zhang, L., Chen, J., Fang, J., & Chen, S. (2014) · Pain · doi:10.1016/j.pain.2014.05.005 · Cited by 41
Mammalian cold TRP channels: impact on thermoregulation and energy homeostasis
Señarís, R. M., Ordás, P., Reimúndez, A., & Viana, F. (2018) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-018-2145-9 · Cited by 41
Cheng, R., Zhu, H., Yan, S., Hang, T., & Zhang, M. (2022) · Food & Function · doi:10.1039/d2fo01198k · Cited by 42
Linking serotonin homeostasis to gut function: Nutrition, gut microbiota and beyond
Jiang, L., Han, D., Hao, Y., Song, Z., Sun, Z., & Dai, Z. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2183935 · Cited by 45
Painful interactions: Microbial compounds and visceral pain
van Thiel, I. A. M., Botschuijver, S., de Jonge, W. J., & Seppen, J. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.165534 · Cited by 44
Lü, Y., Zhang, Z., Tong, L., Zhou, X., Liang, X., Yi, H., Gong, P., Liu, T., Zhang, L., Yang, L., et al. (2021) · Neurogastroenterology & Motility · doi:10.1111/nmo.14082 · Cited by 40
Investigating local and systemic intestinal signalling in health and disease with Drosophila
Medina, A. B., Bellec, K., Polcowñuk, S., & Cordero, J. B. (2022) · Disease Models & Mechanisms · doi:10.1242/dmm.049332 · Cited by 38
Yang, H., & Li, S. (2016) · Medical Science Monitor · doi:10.12659/msm.896557 · Cited by 39
Chapin, A. A., Rajasekaran, P. R., Quan, D. N., Hu, L., Herberholz, J., Bentley, W. E., & Reza Ghodssi, A. (2020) · Microsystems & Nanoengineering · doi:10.1038/s41378-020-00184-4 · Cited by 39
Hao, M., Song, J., Zhai, X., Cheng, N., Xu, C., Gui, S., & Chen, J. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1105272 · Cited by 38
Serotonin signaling to regulate energy metabolism: a gut microbiota perspective
Li, G., Dong, S., Liu, C., Yang, J., Rensen, P. C. N., & Wang, Y. (2024) · Life Metabolism · doi:10.1093/lifemeta/loae039 · Cited by 39
Transient Receptor Potential Channels and Metabolism.
Dhakal, S., & Lee, Y. (2019) · PubMed Central · doi:10.14348/molcells.2019.0007 · Cited by 38
Koo, A., Fothergill, L. J., Kuramoto, H., & Furness, J. B. (2021) · Histochemistry and Cell Biology · doi:10.1007/s00418-021-01972-3 · Cited by 38
Tsuchiya, K., Kubota, K., Ohbuchi, K., Kaneko, A., Ohno, N., Mase, A., Matsushima, H., Yamamoto, M., Miyano, K., Uezono, Y., et al. (2016) · Neurogastroenterology & Motility · doi:10.1111/nmo.12877 · Cited by 38
Transient receptor potential ankyrin 1 (TRPA1) modulators: Recent update and future perspective
Hu, Z., Zhang, Y., Yu, W., Li, J., Yao, J., Zhang, J., Wang, J., & Wang, C. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115392 · Cited by 37
Luminal Amino Acid-Sensing Cells in Gastric Mucosa
Nakamura, E., Hasumura, M., Uneyama, H., & Torii, K. (2011) · Digestion · doi:10.1159/000323399 · Cited by 37
Gastrointestinal hormones and the gut connectome
Ye, L., & Liddle, R. A. (2016) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000299 · Cited by 37
Apomorphine Is a Bimodal Modulator of TRPA1 Channels
Schulze, A., Oehler, B., Urban, N. D., Schaefer, M., & Hill, K. (2012) · Molecular Pharmacology · doi:10.1124/mol.112.081976 · Cited by 37
MacEachern, S. J., Keenan, C. M., Papakonstantinou, E., Sharkey, K. A., & Patel, B. A. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14163 · Cited by 37
Cinnamon, an effective anti‐obesity agent: Evidence from an umbrella meta‐analysis
Keramati, M., Musazadeh, V., Malekahmadi, M., Jamilian, P., Jamilian, P., Ghoreishi, Z., Zarezadeh, M., & Ostadrahimi, A. (2022) · Journal of Food Biochemistry · doi:10.1111/jfbc.14166 · Cited by 36
Ion Channels in Obesity: Pathophysiology and Potential Therapeutic Targets
Vasconcelos, L. H. C., de Souza, I. L. L., Pinheiro, L. S., & da Silva, B. A. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00058 · Cited by 36
Lin, Y., Chen, Z., TANG, J. C. Y., Cao, P., & Shi, R. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.05.029 · Cited by 36
Transient receptor potential (TRP) channels: a metabolic TR(i)P to obesity prevention and therapy
Bishnoi, M., Khare, P., Brown, L., & Panchal, S. K. (2018) · Obesity Reviews · doi:10.1111/obr.12703 · Cited by 37
Albarrán, L., López, J. J., Dionisio, N., Smani, T., Salido, G. M., & Rosado, J. A. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.08.014 · Cited by 35
Yazdanpanah, Z., Azadi‐Yazdi, M., Hooshmandi, H., Ramezani‐Jolfaie, N., & Salehi‐Abargouei, A. (2019) · Phytotherapy Research · doi:10.1002/ptr.6539 · Cited by 35
The role of mechanosensitive ion channels in the gastrointestinal tract
Yang, H., Hou, C., Xiao, W., & Qiu, Y. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.904203 · Cited by 36
Exocytosis in non‐neuronal cells
Thorn, P., Zorec, R., Rettig, J., & Keating, D. J. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13602 · Cited by 33
Fothergill, L. J., Callaghan, B. P., Rivera, L. R., Lieu, T., Poole, D. P., Cho, H., Bravo, D., & Furness, J. B. (2016) · Nutrients · doi:10.3390/nu8100623 · Cited by 34
Ohara, K., Fukuda, T., Ishida, Y., Takahashi, C., Ohya, R., Katayama, M., Uchida, K., Tominaga, M., & Nagai, K. (2017) · Scientific Reports · doi:10.1038/s41598-017-16150-6 · Cited by 34
TRPA1-expressing lamina propria mesenchymal cells regulate colonic motility
Yang, Y., Wang, S., Kobayashi, K., Hao, Y., Kanda, H., Kondo, T., Kogure, Y., Yamanaka, H., Yamamoto, S., Li, J., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.122402 · Cited by 33
Zhao, J., Zhao, L., Zhang, S., & Zhu, C. (2019) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2019.112468 · Cited by 32
Terada, Y., Horie, S., Takayama, H., Uchida, K., Tominaga, M., & Watanabe, T. (2014) · Journal of Natural Products · doi:10.1021/np400885u · Cited by 32
Modulation of the immune response by helminths: a role for serotonin?
Wang, S., Sharkey, K. A., & McKay, D. M. (2018) · Bioscience Reports · doi:10.1042/bsr20180027 · Cited by 34
Correction: Methylglyoxal Evokes Pain by Stimulating TRPA1
Andersson, D. A., Gentry, C., Light, E., Vastani, N., Vallortigara, J., Bierhaus, A., Fleming, T. H., & Bevan, S. (2013) · PLoS ONE · doi:10.1371/annotation/e707d50a-13b3-4cc3-b507-7d8360d8f048 · Cited by 32
Epithelial–Neuronal Communication in the Colon: Implications for Visceral Pain
Najjar, S. A., Davis, B. M., & Albers, K. M. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2019.12.007 · Cited by 32
Dussik, C. M., Hockley, M., Grozić, A., Kaneko, I., Zhang, L., Sabir, M. S., Park, J. K., Wang, J., Nickerson, C. A., Yale, S. H., et al. (2018) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm17021 · Cited by 30
Hu, Y., Gao, X., Zhao, Y. M., Liu, S., Luo, K., Fu, X., Li, J., Sheng, J., Tian, Y., & Fan, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087191 · Cited by 29
Enteric Neural Regulation of Mucosal Secretion
Bornstein, J. C., Gwynne, R. M., & Sjövall, H. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-382026-6.00027-0 · Cited by 29
Chemosensory processing in the taste‐reward pathway
Gutiérrez, R., & Simon, S. A. (2011) · Flavour and Fragrance Journal · doi:10.1002/ffj.2050 · Cited by 29
Mao, Z., Lin, H., Su, W., Li, J., Zhou, M., Li, Z., Zhou, B., Yang, Q., Zhou, M., Pan, K., et al. (2019) · Diabetes · doi:10.2337/db18-1321 · Cited by 29
Serotonergic Control of Gastrointestinal Development, Motility, and Inflammation
Najjar, S. A., Hung, L. Y., & Margolis, K. G. (2023) · Comprehensive physiology · doi:10.1002/j.2040-4603.2023.tb00272.x · Cited by 27
Enterochromaffin Cells: Sentinels to Gut Microbiota in Hyperalgesia?
Xu, X., Chen, R., Zhan, G., Wang, D., Tan, X., & Xu, H. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.760076 · Cited by 31
RNA-Seq Analysis of Enteroendocrine Cells Reveals a Role for FABP5 in the Control of GIP Secretion
Sommer, C., & Mostoslavsky, G. (2014) · Molecular Endocrinology · doi:10.1210/me.2014-1194 · Cited by 29
Chen, Z., Feng, J., Hu, S., Ye, H., Ma, S., Fu, W., Yang, Q., & Zhang, X. (2021) · Digestive Diseases and Sciences · doi:10.1007/s10620-021-07308-4 · Cited by 29
Liang, Q., Wang, J., Bai, Y.-R., Li, R., Wu, C., & Peng, W. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106923 · Cited by 26
GPR119 Agonist AS1269574 Activates TRPA1 Cation Channels to Stimulate GLP-1 Secretion
Chepurny, O. G., Holz, G. G., Roe, M. W., & Leech, C. A. (2016) · Molecular Endocrinology · doi:10.1210/me.2015-1306 · Cited by 24
TRPA1: Pharmacology, natural activators and role in obesity prevention
Mahajan, N. S., Khare, P., Kondepudi, K. K., & Bishnoi, M. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174553 · Cited by 29
Knutson, K. R., Whiteman, S. T., Alcaino, C., Mercado‐Perez, A., Finholm, I. W., Serlin, H. K., Bellampalli, S. S., Linden, D. R., Farrugia, G., & Beyder, A. (2022) · The Journal of Physiology · doi:10.1113/jp283383 · Cited by 27
Gong, J., Nirala, N. K., Chen, J., Wang, F., Gu, P., Wen, Q., Ip, Y. T., & Xiang, Y. (2023) · Science Advances · doi:10.1126/sciadv.adc9660 · Cited by 28
Unsaturated aldehydes induce CCK secretion via TRPA1 in STC‐1 cells
Nakajima, S., Hira, T., Yahagi, A., Nishiyama, C., Yamashita, T., Imagi, J., & Hara, H. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300412 · Cited by 25
Duodenal Luminal Chemosensing; Acid, ATP, and Nutrients
Akiba, Y., & Kaunitz, J. D. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113199990565 · Cited by 25
Martínez-Rojas, V. A., García, G., Noriega‐Navarro, R., Guzmán‐Priego, C. G., Torres‐López, J. E., Granados‐Soto, V., & Murbartián, J. (2017) · Journal of Pain Research · doi:10.2147/jpr.s153671 · Cited by 25
Gastrointestinal motility and its enteric actors in mechanosensitivity: past and present
Mazet, B. (2014) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-014-1635-7 · Cited by 25
Serotonergic Control of Gastrointestinal Development, Motility, and Inflammation
Najjar, S. A., Hung, L. Y., & Margolis, K. G. (2023) · Comprehensive physiology · doi:10.1002/cphy.c220024 · Cited by 53
From dysbiosis to neuropathologies: Toxic effects of glyphosate in zebrafish
Bellot, M., Carrillo, M. P., Bedrossiantz, J., Zheng, J., Mandal, R., Wishart, D. S., Gómez‐Canela, C., Vila‐Costa, M., Prats, E., Piña, B., et al. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.115888 · Cited by 26
The emerging role of gut hormones
Cho, H., & Lim, J. (2024) · Molecules and Cells · doi:10.1016/j.mocell.2024.100126 · Cited by 27
Zhan, Y., Wen, Y., Zhang, L., Shen, X.-L., Chen, X.-H., Wu, X.-H., & Tang, X. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/6076293 · Cited by 24
Gingerol activates noxious cold ion channel TRPA1 in gastrointestinal tract
Yang, M., Lin-Lan, Y. E., Liu, X., Xiao-Ming, Q. I., Jia-Di, L. V., Gang, W. A. N. G., FARHAN, U.-K., Waqas, N., Ding-Ding, C. H. E. N., Lei, H. A. N., et al. (2016) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(16)30040-1 · Cited by 24
Ohara, K., Misaizu, A., Kaneko, Y., Fukuda, T., Miyake, M., Miura, Y., Okamura, H., Yajima, J., & Tsuda, A. (2018) · Nutrients · doi:10.3390/nu11010009 · Cited by 24
Zhang, H., Xia, Y., Wang, G., Xiong, Z., Wei, G., Liao, Z., Qian, Y., Cai, Z., & Ai, L. (2024) · Food & Function · doi:10.1039/d4fo01087f · Cited by 24
Isothiocyanates from Wasabia japonica Activate Transient Receptor Potential Ankyrin 1 Channel
Uchida, K., Miura, Y., Nagai, M., & Tominaga, M. (2012) · Chemical Senses · doi:10.1093/chemse/bjs065 · Cited by 23
Tian, P., Zhu, H., Zou, R., Kong, Q., Xu, M., Zhao, J., Zhang, H., Chen, W., & Wang, G. (2021) · Food & Function · doi:10.1039/d0fo02307h · Cited by 22
The TRPA1 Channel Amplifies the Oxidative Stress Signal in Melanoma
Logu, F. D., de Araújo, D. S. M., Ugolini, F., Iannone, L. F., Vannucchi, M., Portelli, F., Landini, L., Titiz, M., GIORGI, V. D., Geppetti, P., et al. (2021) · Cells · doi:10.3390/cells10113131 · Cited by 22
Nociceptor-derived Reg3γ prevents endotoxic death by targeting kynurenine pathway in microglia
Sugisawa, E., Kondo, T., Kumagai, Y., Kato, H., Takayama, Y., Isohashi, K., Shimosegawa, E., Takemura, N., Hayashi, Y., Sasaki, T., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110462 · Cited by 23
Terada, Y., Yamashita, R., Ihara, N., Yamazaki‐Ito, T., Takahashi, Y., Masuda, H., Sakuragawa, S., Ito, S., Ito, K., & Watanabe, T. (2019) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2019.1611405 · Cited by 22
Involvement of cholinergic nicotinic receptors in the menthol-induced gastric relaxation
Amato, A., Serio, R., & Mulè, F. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.10.012 · Cited by 22
Saito, H., Nakakita, Y., Segawa, S., & Tsuchiya, Y. (2019) · Beneficial Microbes · doi:10.3920/bm2018.0091 · Cited by 21
Role of TRPA1 in Tissue Damage and Kidney Disease
Wu, C., Lin, J., Lee, T., Kou, Y. R., & Tarng, D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073415 · Cited by 21
Casini, A., Mancinelli, R., Mammola, C. L., Pannarale, L., Chirletti, P., Onori, P., & Vaccaro, R. (2021) · European Journal of Histochemistry · doi:10.4081/ejh.2021.3310 · Cited by 23
TRPA1 Agonist Activity of Probenecid Desensitizes Channel Responses: Consequences for Screening
McClenaghan, C., Zeng, F., & Verkuyl, J. M. (2012) · Assay and Drug Development Technologies · doi:10.1089/adt.2012.447 · Cited by 21
Activation of host transient receptor potential (TRP) channels by praziquantel stereoisomers
Gunaratne, G. S., Yahya, N. A., Dosa, P. I., & Marchant, J. S. (2018) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0006420 · Cited by 21
Pravda, J. (2022) · World Journal of Gastroenterology · doi:10.3748/wjg.v28.i31.4263 · Cited by 23
Shear stress activates nociceptors to drive Drosophila mechanical nociception
Gong, J., Chen, J., Gu, P., Shang, Y., Takle, K. A., Yang, Y. T., Wang, F., Wen, Q., & Xiang, Y. (2022) · Neuron · doi:10.1016/j.neuron.2022.08.015 · Cited by 20
Aqueous cinnamon extract ameliorates bowel dysfunction and enteric 5-HT synthesis in IBS rats
Yu, L., Huang, C., Yang, W., Ren, Z., Li, L., Cheng, H., Lin, C., Zhai, L., Ning, Z., Wong, H. L. X., et al. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1010484 · Cited by 22
Zhang, L. Y., Dong, X., Liu, Z., Mo, J. Z., Fang, J., Xiao, S., Li, Y., & Chen, S. L. (2010) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2010.01589.x · Cited by 20
Luminal chemosensing in the gastroduodenal mucosa
Kaji, I., & Kaunitz, J. D. (2017) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000396 · Cited by 21
Colonic 5‐HT4 receptors are targets for novel prokinetic drugs
Galligan, J. J. (2021) · Neurogastroenterology & Motility · doi:10.1111/nmo.14125 · Cited by 18
Bioelectric regulation of intestinal stem cells
Petsakou, A., & Perrimon, N. (2022) · Trends in Cell Biology · doi:10.1016/j.tcb.2022.10.003 · Cited by 20
Watanabe, J. A., Kaifuchi, N., Kushida, H., Matsumoto, T., Fukutake, M., Nishiyama, M., Yamamoto, M., & Kono, T. (2015) · Pharmacology Research & Perspectives · doi:10.1002/prp2.165 · Cited by 18
Metadata
- Authors
- Nozawa, K., Kawabata-Shoda, E., Doihara, H., Kojima, R., Okada, H., Mochizuki, S., Sano, Y., Inamura, K., Matsushime, H., Koizumi, T., Yokoyama, T., & Ito, H.
- Affiliations
- Astellas Pharma (Japan) (JP)
- Corresponding author
- Nozawa, Katsura
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2009-03-03
- Volume
- 106
- Issue
- 9
- Pages
- 3408-3413
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2651261
- OpenAlex
- W2156291426
- Cited by
- 399
- References
- 49
- Citations by year
- 2026: 16 · 2025: 32 · 2024: 20 · 2023: 31 · 2022: 25 · 2021: 46 · 2020: 18 · 2019: 23 · 2018: 24 · 2017: 21 · 2016: 24 · 2015: 15 · 2014: 21 · 2013: 24 · 2012: 21
- FWCI
- 9.74
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
- Keywords
- TRPA1, enterochromaffin cells, serotonin release, gastrointestinal motility, allyl isothiocyanate, cinnamaldehyde, 5-HT3 receptor, ileal contraction, intracellular calcium, sensory transduction
- MeSH terms
- TRPA1 Cation Channel, Animals, Calcium, Cell Line, Enterochromaffin Cells, Gastrointestinal Motility, Gene Expression Regulation, Guinea Pigs, Humans, Male, Nerve Tissue Proteins, Serotonin, Calcium Channels, Ankyrins, Transient Receptor Potential Channels, TRPC Cation Channels, Mice, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review