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Flg22 regulates the release of an ethylene response factor substrate from MAP kinase 6 in Arabidopsis thaliana via ethylene signaling
Open accessAbstract
Mitogen-activated protein kinase (MAPK)–mediated responses are in part regulated by the repertoire of MAPK substrates, which is still poorly elucidated in plants. Here, the in vivo enzyme–substrate interaction of the Arabidopsis thaliana MAP kinase, MPK6, with an ethylene response factor (ERF104) is shown by fluorescence resonance energy transfer. The interaction was rapidly lost in response to flagellin-derived flg22 peptide. This complex disruption requires not only MPK6 activity, which also affects ERF104 stability via phosphorylation, but also ethylene signaling. The latter points to a novel role of ethylene in substrate release, presumably allowing the liberated ERF104 to access target genes. Microarray data show enrichment of GCC motifs in the promoters of ERF104–up-regulated genes, many of which are stress related. ERF104 is a vital regulator of basal immunity, as altered expression in both erf104 and overexpressors led to more growth inhibition by flg22 and enhanced susceptibility to a non-adapted bacterial pathogen.
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Citations
Cites
Emerging MAP kinase pathways in plant stress signalling
Nakagami, H., Pitzschke, A., & Hirt, H. (2005) · Trends in Plant Science · doi:10.1016/j.tplants.2005.05.009 · Cited by 676
Cited by
Plant immunity: towards an integrated view of plant–pathogen interactions
Dodds, P. N., & Rathjen, J. P. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2812 · Cited by 3,424
MAPK Cascades in Plant Disease Resistance Signaling
Meng, X., & Zhang, S. (2013) · Annual Review of Phytopathology · doi:10.1146/annurev-phyto-082712-102314 · Cited by 1,367
Signaling Mechanisms in Pattern-Triggered Immunity (PTI)
Bigeard, J., Colcombet, J., & Hirt, H. (2015) · Molecular Plant · doi:10.1016/j.molp.2014.12.022 · Cited by 1,105
Mitogen-Activated Protein Kinase Signaling in Plants
Cristina, M., Petersen, M., & Mundy, J. (2010) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-042809-112252 · Cited by 1,103
Licausi, F., Ohme‐Takagi, M., & Perata, P. (2013) · New Phytologist · doi:10.1111/nph.12291 · Cited by 1,020
Metadata
- Authors
- Bethke, G., Unthan, T., Uhrig, J. F., Pöschl, Y., Gust, A. A., Scheel, D., & Lee, J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2009-05-12
- Volume
- 106
- Issue
- 19
- Pages
- 8067-8072
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2088101238
- Cited by
- 361
- References
- 1
- FWCI
- 26.07
- Type
- journal article
- Language
- en
- Open access
- green
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- Bethke, G., Unthan, T., Uhrig, J. F., Pöschl, Y., Gust, A. A., Scheel, D., & Lee, J. (2009). Flg22 regulates the release of an ethylene response factor substrate from MAP kinase 6 in Arabidopsis thaliana via ethylene signaling. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0810206106
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