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Three-dimensional microfluidic devices fabricated in layered paper and tape
Open accessAbstract
This article describes a method for fabricating 3D microfluidic devices by stacking layers of patterned paper and double-sided adhesive tape. Paper-based 3D microfluidic devices have capabilities in microfluidics that are difficult to achieve using conventional open-channel microsystems made from glass or polymers. In particular, 3D paper-based devices wick fluids and distribute microliter volumes of samples from single inlet points into arrays of detection zones (with numbers up to thousands). This capability makes it possible to carry out a range of new analytical protocols simply and inexpensively (all on a piece of paper) without external pumps. We demonstrate a prototype 3D device that tests 4 different samples for up to 4 different analytes and displays the results of the assays in a side-by-side configuration for easy comparison. Three-dimensional paper-based microfluidic devices are especially appropriate for use in distributed healthcare in the developing world and in environmental monitoring and water analysis.
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Cited by
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Bhattacharjee, N., Urrios, A., Kang, S., & Folch, A. (2016) · Lab on a Chip · doi:10.1039/c6lc00163g · Cited by 1,123
Inspiration and application in the evolution of biomaterials
Huebsch, N., & Mooney, D. J. (2009) · Nature · doi:10.1038/nature08601 · Cited by 855
Au, A. K., Huynh, W., Horowitz, L. F., & Folch, A. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201504382 · Cited by 788
Wood-based nanotechnologies toward sustainability
Jiang, F., Li, T., Li, Y., Zhang, Y., Gong, A., Dai, J., Hitz, E., Luo, W., & Hu, L. (2018) · Advanced Materials · doi:10.1002/adma.201703453 · Cited by 599
Metadata
- Authors
- Martinez, A. W., Phillips, S. T., & Whitesides, G. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2008-12-16
- Volume
- 105
- Issue
- 50
- Pages
- 19606-19611
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2010659423
- Cited by
- 1,246
- References
- 0
- FWCI
- 31.34
- Type
- journal article
- Language
- en
- Open access
- green
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- Martinez, A. W., Phillips, S. T., & Whitesides, G. M. (2008). Three-dimensional microfluidic devices fabricated in layered paper and tape. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0810903105
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
