The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Thymic stromal lymphopoietin overproduced by keratinocytes in mouse skin aggravates experimental asthma
Open accessAbstract
Atopic dermatitis (AD) is often the initial step in the “atopic march,” given that more than half of AD patients with moderate to severe AD develop asthma later in life. Both AD and asthma share a similar “atopy” phenotype that includes T helper type 2 inflammation with eosinophilia and hyper-IgE immunoglobulinemia, but the molecular mechanisms underlying the “atopic march” remain elusive. In the present study, we show that induced expression of thymic stromal lymphopoietin (TSLP) in mouse epidermal keratinocytes upon topical application of MC903 (a low calcemic analogue of vitamin D3) not only triggers AD as we previously reported but also aggravates experimental allergic asthma induced by ovalbumin sensitization and challenge. Our study, which provides a mouse model to study human “atopic march,” indicates that keratinocyte-produced TSLP may represent an important factor in the link of atopic dermatitis to asthma.
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Citations
Cites
New insights into atopic dermatitis
Leung, D. Y. M., Boguniewicz, M., Howell, M. D., Nomura, I., & Hamid, Q. A. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21060 · Cited by 1,435
Atopic dermatitis and the atopic march
Spergel, J. M., & Paller, A. S. (2003) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2003.09.033 · Cited by 1,229
Cited by
Sensing the outside world: TSLP regulates barrier immunity
Ziegler, S. F., & Artis, D. (2010) · Nature Immunology · doi:10.1038/ni.1852 · Cited by 560
Thymic stromal lymphopoietin–elicited basophil responses promote eosinophilic esophagitis
Noti, M., Wojno, E. D. T., Kim, B. S., Siracusa, M. C., Giacomin, P. R., Nair, M. G., Benitez, A. J., Ruymann, K. R., Muir, A. B., Hill, D. A., et al. (2013) · Nature Medicine · doi:10.1038/nm.3281 · Cited by 422
The multifunctional role of filaggrin in allergic skin disease
McAleer, M. A., & Irvine, A. D. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.12.668 · Cited by 419
Pathophysiology of allergic inflammation
Barnes, P. J. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01020.x · Cited by 361
Skin Barrier Disruption: A Requirement for Allergen Sensitization?
De Benedetto, A., Kubo, A., & Beck, L. A. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.435 · Cited by 317
Metadata
- Authors
- Zhang, Z., Hener, P., Frossard, N., Kato, S., Metzger, D., Li, M., & Chambon, P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2009-02-03
- Volume
- 106
- Issue
- 5
- Pages
- 1536-1541
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1986889826
- Cited by
- 184
- References
- 2
- FWCI
- 22.30
- Type
- journal article
- Language
- en
- Open access
- green
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- Zhang, Z., Hener, P., Frossard, N., Kato, S., Metzger, D., Li, M., & Chambon, P. (2009). Thymic stromal lymphopoietin overproduced by keratinocytes in mouse skin aggravates experimental asthma. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0812668106
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