The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Stem cells are dispensable for lung homeostasis but restore airways after injury
Open accessAbstract
Local tissue stem cells have been described in airways of the lung but their contribution to normal epithelial maintenance is currently unknown. We therefore developed aggregation chimera mice and a whole-lung imaging method to determine the relative contributions of progenitor (Clara) and bronchiolar stem cells to epithelial maintenance and repair. In normal and moderately injured airways chimeric patches were small in size and not associated with previously described stem cell niches. This finding suggested that single, randomly distributed progenitor cells maintain normal epithelial homeostasis. In contrast we found that repair following severe lung injury resulted in the generation of rare, large clonal cell patches that were associated with stem cell niches. This study provides evidence that epithelial stem cells are dispensable for normal airway homeostasis. We also demonstrate that stem cell activation and robust clonal cellular expansion occur only during repair from severe lung injury.
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Cites
Gurtner, G. C., Werner, S., Barrandon, Y., & Longaker, M. T. (2008) · Nature · doi:10.1038/nature07039 · Cited by 6,542
Identification of stem cells in small intestine and colon by marker gene Lgr5
Barker, N., van Es, J. H., Kuipers, J., Kujala, P., van den Born, M., Cozijnsen, M., Haegebarth, A., Korving, J., Begthel, H., Peters, P. J., et al. (2007) · Nature · doi:10.1038/nature06196 · Cited by 5,687
Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation
Dor, Y., Brown, J., Martinez, O. I., & Melton, D. A. (2004) · Nature · doi:10.1038/nature02520 · Cited by 2,219
A single type of progenitor cell maintains normal epidermis
Clayton, E., Doupé, D. P., Klein, A. M., Winton, D. J., Simons, B. D., & Jones, P. H. (2007) · Nature · doi:10.1038/nature05574 · Cited by 853
Cited by
The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future
Basil, M. C., Katzen, J., Engler, A. E., Guo, M., Herriges, M. J., Kathiriya, J. J., Windmueller, R., Ysasi, A. B., Zacharias, W. J., Chapman, H. A., et al. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2020.03.009 · Cited by 414
Lung regeneration by multipotent stem cells residing at the bronchioalveolar-duct junction
Liu, Q., Liu, K., Cui, G., Huang, X., Yao, S., Guo, W., Qin, Z., Li, Y., Yang, R., Pu, W., et al. (2019) · Nature Genetics · doi:10.1038/s41588-019-0346-6 · Cited by 319
Stem Cells and Cell Therapies in Lung Biology and Lung Diseases
Weiss, D. J., Kolls, J. K., Ortiz, L. A., Panoskaltsis-Mortari, A., & Prockop, D. J. (2008) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200804-037dw · Cited by 309
Fu, Q., Gremeaux, L., Luque, R. M., Liekens, D., Chen, J., Buch, T., Waisman, A., Kineman, R., & Vankelecom, H. (2012) · Endocrinology · doi:10.1210/en.2012-1152 · Cited by 105
Regeneration and repair in the healing lung
Lucas, A., Yasa, J., & Lucas, M. (2020) · Clinical & Translational Immunology · doi:10.1002/cti2.1152 · Cited by 41
Metadata
- Authors
- Giangreco, A., Arwert, E. N., Rosewell, I. R., Snyder, J., Watt, F. M., & Stripp, B. R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2009-06-09
- Volume
- 106
- Issue
- 23
- Pages
- 9286-9291
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2158958245
- Cited by
- 241
- References
- 4
- FWCI
- 23.12
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Giangreco, A., Arwert, E. N., Rosewell, I. R., Snyder, J., Watt, F. M., & Stripp, B. R. (2009). Stem cells are dispensable for lung homeostasis but restore airways after injury. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0900668106
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
