The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Long-term survival following a single treatment of kidney tumors with multiwalled carbon nanotubes and near-infrared radiation
Open accessAbstract
Multiwalled carbon nanotubes (MWCNTs) exhibit physical properties that render them ideal candidates for application as noninvasive mediators of photothermal cancer ablation. Here, we demonstrate that use of MWCNTs to generate heat in response to near-infrared radiation (NIR) results in thermal destruction of kidney cancer in vitro and in vivo. We document the thermal effects of the therapy through magnetic resonance temperature-mapping and heat shock protein-reactive immunohistochemistry. Our results demonstrate that use of MWCNTs enables ablation of tumors with low laser powers (3 W/cm 2 ) and very short treatment times (a single 30-sec treatment) with minimal local toxicity and no evident systemic toxicity. These treatment parameters resulted in complete ablation of tumors and a >3.5-month durable remission in 80% of mice treated with 100 μg of MWCNT. Use of MWCNTs with NIR may be effective in anticancer therapy.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A clearer vision for in vivo imaging
Weissleder, R. (2001) · Nature Biotechnology · doi:10.1038/86684 · Cited by 3,839
Poland, C. A., Duffin, R., Kinloch, I., Maynard, A., Wallace, W. A. H., Seaton, A., Stone, V., Brown, S., MacNee, W., & Donaldson, K. (2008) · Nature Nanotechnology · doi:10.1038/nnano.2008.111 · Cited by 2,645
Mechanisms of Cancer Drug Resistance
Gottesman, M. M. (2002) · Annual Review of Medicine · doi:10.1146/annurev.med.53.082901.103929 · Cited by 2,643
Plasmonic photothermal therapy (PPTT) using gold nanoparticles
Huang, X., Jain, P. K., El-Sayed, I. H., & El-Sayed, M. A. (2008) · Lasers in Medical Science · doi:10.1007/s10103-007-0470-x · Cited by 2,376
Kam, N. W. S., O'Connell, M., Wisdom, J. A., & Dai, H. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502680102 · Cited by 2,307
Dresselhaus, M. S. (1995) · Cited by 2,050
Photo-thermal tumor ablation in mice using near infrared-absorbing nanoparticles
O'Neal, D. P., Hirsch, L. R., Halas, N. J., Payne, J. D., & West, J. L. (2004) · Cancer Letters · doi:10.1016/j.canlet.2004.02.004 · Cited by 1,849
The cellular and molecular basis of hyperthermia
Hildebrandt, B. (2002) · Critical Reviews in Oncology/Hematology · doi:10.1016/s1040-8428(01)00179-2 · Cited by 1,718
Drug Delivery with Carbon Nanotubes for In vivo Cancer Treatment
Liu, Z., Chen, K., Davis, C., Sherlock, S., Cao, Q., Chen, X., & Dai, H. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1468 · Cited by 1,348
Singh, R., Pantarotto, D., McCarthy, D., Chaloin, O., Hoebeke, J., Partidos, C. D., Briand, J.-P., Prato, M., Bianco, A., & Kostarelos, K. (2005) · Journal of the American Chemical Society · doi:10.1021/ja0441561 · Cited by 759
Self-citation
Cited by
Near-infrared light-responsive nanomaterials in cancer therapeutics
Shanmugam, V., Selvakumar, S., & Yeh, C.-S. (2014) · Chem. Soc. Rev. · doi:10.1039/c4cs00011k · Cited by 869
Carbon materials for drug delivery & cancer therapy
Liu, Z., Robinson, J. T., Tabakman, S. M., Yang, K., & Dai, H. (2011) · Materials Today · doi:10.1016/s1369-7021(11)70161-4 · Cited by 600
Markovic, Z. M., Harhaji-Trajkovic, L. M., Todorovic-Markovic, B. M., Kepić, D. P., Arsikin, K. M., Jovanović, S. P., Pantovic, A. C., Dramićanin, M. D., & Trajkovic, V. S. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2010.10.030 · Cited by 560
Nanoparticle-mediated Hyperthermia in Cancer Therapy
Chatterjee, D. K., Diagaradjane, P., & Krishnan, S. (2011) · Therapeutic Delivery · doi:10.4155/tde.11.72 · Cited by 417
Ren, J., Shen, S., Wang, D., Xi, Z., Guo, L., Pang, Z., Qian, Y., Sun, X., & Jiang, X. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.01.025 · Cited by 408
Metadata
- Authors
- Burke, A., Ding, X., Singh, R., Kraft, R. A., Levi-Polyachenko, N., Rylander, M. N., Szot, C., Buchanan, C., Whitney, J., Fisher, J., Hatcher, H. C., D'Agostino, R., Kock, N. D., Ajayan, P. M., Carroll, D. L., Akman, S., Torti, F. M., & Torti, S. V.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2009-08-04
- Volume
- 106
- Issue
- 31
- Pages
- 12897-12902
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2035166438
- Cited by
- 340
- References
- 29
- FWCI
- 18.44
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Long-term survival following a single treatment of kidney tumors with multiwalled carbon nanotubes and near-infrared radiation. https://app.cochat.ai/papers/10.1073/pnas.0905195106
- The paper
- Burke, A., Ding, X., Singh, R., Kraft, R. A., Levi-Polyachenko, N., Rylander, M. N., Szot, C., Buchanan, C., Whitney, J., Fisher, J., Hatcher, H. C., D'Agostino, R., Kock, N. D., Ajayan, P. M., Carroll, D. L., Akman, S., Torti, F. M., & Torti, S. V. (2009). Long-term survival following a single treatment of kidney tumors with multiwalled carbon nanotubes and near-infrared radiation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0905195106
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
