The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Continuous imaging of plasmon rulers in live cells reveals early-stage caspase-3 activation at the single-molecule level
Open accessAbstract
The use of plasmon coupling in metal nanoparticles has shown great potential for the optical characterization of many biological processes. Recently, we have demonstrated the use of “plasmon rulers” to observe conformational changes of single biomolecules in vitro. Plasmon rulers provide robust signals without photobleaching or blinking. Here, we show the first application of plasmon rulers to in vivo studies to observe very long trajectories of single biomolecules in live cells. We present a unique type of plasmon ruler comprised of peptide-linked gold nanoparticle satellites around a core particle, which was used as a probe to optically follow cell-signaling pathways in vivo at the single-molecule level. These “crown nanoparticle plasmon rulers” allowed us to continuously monitor trajectories of caspase-3 activity in live cells for over 2 h, providing sufficient time to observe early-stage caspase-3 activation, which was not possible by conventional ensemble analyses.
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Cites
Visualization of Single RNA Transcripts in Situ
Femino, A. M., Fay, F. S., Fogarty, K., & Singer, R. H. (1998) · Science · doi:10.1126/science.280.5363.585 · Cited by 1,504
A Stochastic Single-Molecule Event Triggers Phenotype Switching of a Bacterial Cell
Choi, P. J., Cai, L., Frieda, K., & Xie, X. S. (2008) · Science · doi:10.1126/science.1161427 · Cited by 438
Cited by
Three-Dimensional Plasmon Rulers
Liu, N., Hentschel, M., Weiss, T., Alivisatos, A. P., & Giessen, H. (2011) · Science · doi:10.1126/science.1199958 · Cited by 580
Self-citationSong, J., Zhou, J., & Duan, H. (2012) · Journal of the American Chemical Society · doi:10.1021/ja305154a · Cited by 438
Metadata
- Authors
- Jun, Y.-W., Sheikholeslami, S., Hostetter, D. R., Tajon, C., Craik, C. S., & Alivisatos, A. P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2009-10-20
- Volume
- 106
- Issue
- 42
- Pages
- 17735-17740
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2004987572
- Cited by
- 189
- References
- 2
- FWCI
- 8.10
- Type
- journal article
- Language
- en
- Open access
- green
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- Jun, Y.-W., Sheikholeslami, S., Hostetter, D. R., Tajon, C., Craik, C. S., & Alivisatos, A. P. (2009). Continuous imaging of plasmon rulers in live cells reveals early-stage caspase-3 activation at the single-molecule level. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0907367106
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