The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Adoptively transferred effector cells derived from naïve rather than central memory CD8+T cells mediate superior antitumor immunity
Open accessAbstract
Effector cells derived from central memory CD8+T cells were reported to engraft and survive better than those derived from effector memory populations, suggesting that they are superior for use in adoptive immunotherapy studies. However, previous studies did not evaluate the relative efficacy of effector cells derived from naïve T cells. We sought to investigate the efficacy of tumor-specific effector cells derived from naïve or central memory T-cell subsets using transgenic or retrovirally transduced T cells engineered to express a tumor-specific T-cell receptor. We found that naïve, rather than central memory T cells, gave rise to an effector population that mediated superior antitumor immunity upon adoptive transfer. Effector cells developed from naïve T cells lost the expression of CD62L more rapidly than those derived from central memory T cells, but did not acquire the expression of KLRG-1, a marker for terminal differentiation and replicative senescence. Consistent with this KLRG-1−phenotype, naïve-derived cells were capable of a greater proliferative burst and had enhanced cytokine production after adoptive transfer. These results indicate that insertion of genes that confer antitumor specificity into naïve rather than central memory CD8+T cells may allow superior efficacy upon adoptive transfer.
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Cites
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
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“Resting CD8 T cells exist as naïve (TN), central memory (TCM), and effector memory (TEM) populations, each with distinct phenotypic and functional characteristics (11).”
BackgroundCancer regression in patients after transfer of genetically engineered lymphocytes
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Self-citationCD8+ T cell efficacy in vaccination and disease
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Cited by
A human memory T cell subset with stem cell–like properties
Gattinoni, L., Lugli, E., Ji, Y., Pos, Z., Paulos, C. M., Quigley, M. F., Almeida, J. R., Gostick, E., Yu, Z., Carpenito, C., et al. (2011) · Nature Medicine · doi:10.1038/nm.2446 · Cited by 1,974
Self-citationFraietta, J. A., Lacey, S. F., Orlando, E. J., Pruteanu-Malinici, I., Gohil, M., Lundh, S., Boesteanu, A. C., Wang, Y., O’Connor, R. S., Hwang, W.-T., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0010-1 · Cited by 1,785
Adoptive immunotherapy for cancer: harnessing the T cell response
Restifo, N. P., Dudley, M. E., & Rosenberg, S. A. (2012) · Nature Reviews Immunology · doi:10.1038/nri3191 · Cited by 1,688
Self-citationSommermeyer, D., Hudecek, M., Kosasih, P. L., Gogishvili, T., Maloney, D. G., Turtle, C. J., & Riddell, S. R. (2016) · Leukemia · doi:10.1038/leu.2015.247 · Cited by 867
T memory stem cells in health and disease
Gattinoni, L., Speiser, D. E., Lichterfeld, M., & Bonini, C. (2017) · Nature Medicine · doi:10.1038/nm.4241 · Cited by 620
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Metadata
- Authors
- Hinrichs, C. S., Borman, Z. A., Cassard, L., Gattinoni, L., Spolski, R., Yu, Z., Sanchez-Perez, L., Muranski, P., Kern, S. J., Logun, C., Palmer, D. C., Ji, Y., Reger, R. N., Leonard, W. J., Danner, R. L., Rosenberg, S. A., & Restifo, N. P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2009-10-13
- Volume
- 106
- Issue
- 41
- Pages
- 17469-17474
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2070669774
- Cited by
- 387
- References
- 5
- FWCI
- 12.22
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Hinrichs, C. S., Borman, Z. A., Cassard, L., Gattinoni, L., Spolski, R., Yu, Z., Sanchez-Perez, L., Muranski, P., Kern, S. J., Logun, C., Palmer, D. C., Ji, Y., Reger, R. N., Leonard, W. J., Danner, R. L., Rosenberg, S. A., & Restifo, N. P. (2009). Adoptively transferred effector cells derived from naïve rather than central memory CD8+T cells mediate superior antitumor immunity. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0907448106
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