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Cited by 264

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Mitochondrial genome evidence reveals successful Late Paleolithic settlement on the Tibetan Plateau

Open access
Zhao, Mian, Kong, Qing-Peng, Wang, Hua-Wei, Peng, Min-Sheng, Xie, Xiao-Dong, Wang, Wen-Zhi, Jiayang, Duan, Jian-Guo, Cai, Ming-Cui, Zhao, Shi-Neng, Cidanpingcuo, Tu, Yuan-Quan, Wu, Shi-Fang, Yao, Yong-Gang, Bandelt, Hans-Jürgen, Zhang, Ya-Ping·2009·Proceedings of the National Academy of Sciences

Abstract

Due to its numerous environmental extremes, the Tibetan Plateau—the world's highest plateau—is one of the most challenging areas of modern human settlement. Archaeological evidence dates the earliest settlement on the plateau to the Late Paleolithic, while previous genetic studies have traced the colonization event(s) to no earlier than the Neolithic. To explore whether the genetic continuity on the plateau has an exclusively Neolithic time depth, we studied mitochondrial DNA (mtDNA) genome variation within 6 regional Tibetan populations sampled from Tibet and neighboring areas. Our results confirm that the vast majority of Tibetan matrilineal components can trace their ancestry to Epipaleolithic and Neolithic immigrants from northern China during the mid-Holocene. Significantly, we also identified an infrequent novel haplogroup, M16, that branched off directly from the Eurasian M founder type. Its nearly exclusive distribution in Tibetan populations and ancient age (>21 kya) suggest that M16 may represent the genetic relics of the Late Paleolithic inhabitants on the plateau. This partial genetic continuity between the Paleolithic inhabitants and the contemporary Tibetan populations bridges the results and inferences from archaeology, history, and genetics.

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Metadata

Authors
Zhao, M., Kong, Q.-P., Wang, H.-W., Peng, M.-S., Xie, X.-D., Wang, W.-Z., Jiayang, Duan, J.-G., Cai, M.-C., Zhao, S.-N., Cidanpingcuo, Tu, Y.-Q., Wu, S.-F., Yao, Y.-G., Bandelt, H.-J., & Zhang, Y.-P.
Venue
Proceedings of the National Academy of Sciences
Published
2009-12-15
Volume
106
Issue
50
Pages
21230-21235
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2151242378
Cited by
264
References
46
FWCI
7.31
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Mitochondrial genome evidence reveals successful Late Paleolithic settlement on the Tibetan Plateau. https://app.cochat.ai/papers/10.1073/pnas.0907844106
The paper
Zhao, M., Kong, Q.-P., Wang, H.-W., Peng, M.-S., Xie, X.-D., Wang, W.-Z., Jiayang, Duan, J.-G., Cai, M.-C., Zhao, S.-N., Cidanpingcuo, Tu, Y.-Q., Wu, S.-F., Yao, Y.-G., Bandelt, H.-J., & Zhang, Y.-P. (2009). Mitochondrial genome evidence reveals successful Late Paleolithic settlement on the Tibetan Plateau. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0907844106

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