The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Role of DAB2IP in modulating epithelial-to-mesenchymal transition and prostate cancer metastasis
Open accessAbstract
A single nucleotide polymorphism in the DAB2IP gene is associated with risk of aggressive prostate cancer (PCa), and loss of DAB2IP expression is frequently detected in metastatic PCa. However, the functional role of DAB2IP in PCa remains unknown. Here, we show that the loss of DAB2IP expression initiates epithelial-to-mesenchymal transition (EMT), which is visualized by repression of E-cadherin and up-regulation of vimentin in both human normal prostate epithelial and prostate carcinoma cells as well as in clinical prostate-cancer specimens. Conversely, restoring DAB2IP in metastatic PCa cells reversed EMT. In DAB2IP knockout mice, prostate epithelial cells exhibited elevated mesenchymal markers, which is characteristic of EMT. Using a human prostate xenograft-mouse model, we observed that knocking down endogenous DAB2IP in human carcinoma cells led to the development of multiple lymph node and distant organ metastases. Moreover, we showed that DAB2IP functions as a scaffold protein in regulating EMT by modulating nuclear β-catenin/T-cell factor activity. These results show the mechanism of DAB2IP in EMT and suggest that assessment of DAB2IP may provide a prognostic biomarker and potential therapeutic target for PCa metastasis.
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Molecular determinants of resistance to antiandrogen therapy
Chen, C. D., Welsbie, D. S., Tran, C., Baek, S. H., Chen, R., Vessella, R., Rosenfeld, M. G., & Sawyers, C. L. (2004) · Nature Medicine · doi:10.1038/nm972 · Cited by 2,278
Erk Associates with and Primes GSK-3β for Its Inactivation Resulting in Upregulation of β-Catenin
Ding, Q., Xia, W., Liu, J.-C., Yang, J.-Y., Lee, D.-F., Xia, J., Bartholomeusz, G., Li, Y., Pan, Y., Li, Z., et al. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.06.009 · Cited by 597
Self-citationRole that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis
McManus, E. J., Sakamoto, K., Armit, L. J., Ronaldson, L., Shpiro, N., Marquez, R., & Alessi, D. R. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600633 · Cited by 594
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SnapShot: The Epithelial-Mesenchymal Transition
Sleeman, J. P., & Thiery, J. P. (2011) · Cell · doi:10.1016/j.cell.2011.03.029 · Cited by 130
Cited by
Yu, J., Yu, J., Mani, R.-S., Cao, Q., Brenner, C. J., Cao, X., Wang, X., Wu, L., Li, J., Hu, M., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.03.018 · Cited by 850
Li, Z., Hou, P., Fan, D., Dong, M., Ma, M., Li, H., Yao, R., Li, Y., Wang, G., Geng, P., et al. (2017) · Cell Death & Differentiation · doi:10.1038/cdd.2016.95 · Cited by 339
Zhang, L., Valdez, J. M., Zhang, B., Wei, L., Chang, J., & Xin, L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018271 · Cited by 95
Metadata
- Authors
- Xie, D., Gore, C., Liu, J., Pong, R.-C., Mason, R., Hao, G., Long, M., Kabbani, W., Yu, L., Zhang, H., Chen, H., Sun, X., Boothman, D. A., Min, W., & Hsieh, J.-T.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2010-01-13
- Volume
- 107
- Issue
- 6
- Pages
- 2485-2490
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2018649033
- Cited by
- 237
- References
- 5
- FWCI
- 16.97
- Type
- journal article
- Language
- en
- Open access
- green
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- Xie, D., Gore, C., Liu, J., Pong, R.-C., Mason, R., Hao, G., Long, M., Kabbani, W., Yu, L., Zhang, H., Chen, H., Sun, X., Boothman, D. A., Min, W., & Hsieh, J.-T. (2010). Role of DAB2IP in modulating epithelial-to-mesenchymal transition and prostate cancer metastasis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0908133107
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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