The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Dietary branched chain amino acids ameliorate injury-induced cognitive impairment
Open accessAbstract
Neurological dysfunction caused by traumatic brain injury results in profound changes in net synaptic efficacy, leading to impaired cognition. Because excitability is directly controlled by the balance of excitatory and inhibitory activity, underlying mechanisms causing these changes were investigated using lateral fluid percussion brain injury in mice. Although injury-induced shifts in net synaptic efficacy were not accompanied by changes in hippocampal glutamate and GABA levels, significant reductions were seen in the concentration of branched chain amino acids (BCAAs), which are key precursors to de novo glutamate synthesis. Dietary consumption of BCAAs restored hippocampal BCAA concentrations to normal, reversed injury-induced shifts in net synaptic efficacy, and led to reinstatement of cognitive performance after concussive brain injury. All brain-injured mice that consumed BCAAs demonstrated cognitive improvement with a simultaneous restoration in net synaptic efficacy. Posttraumatic changes in the expression of cytosolic branched chain aminotransferase, branched chain ketoacid dehydrogenase, glutamate dehydrogenase, and glutamic acid decarboxylase support a perturbation of BCAA and neurotransmitter metabolism. Ex vivo application of BCAAs to hippocampal slices from injured animals restored posttraumatic regional shifts in net synaptic efficacy as measured by field excitatory postsynaptic potentials. These results suggest that dietary BCAA intervention could promote cognitive improvement by restoring hippocampal function after a traumatic brain injury.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Using an animal model of TBI, Cole et al. (2010) reported improved cognition in rats supplemented with BCAAs following lateral fluid percussion injury.”
From Alzheimer’s disease: Targeting the glutamatergic system (2020) · cites this paper as Cole et al. 2010
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Incidence of Traumatic Brain Injury in the United States, 2003
Rutland-Brown, W., Langlois, J. A., Thomas, K. E., & Xi, Y. L. (2006) · Journal of Head Trauma Rehabilitation · doi:10.1097/00001199-200611000-00009 · Cited by 836
Lowenstein, D. H., Thomas, M., Smith, D., & McIntosh, T. K. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-12-04846.1992 · Cited by 686
Social adjustment after closed head injury: a further follow-up seven years after injury.
Oddy, M., Coughlan, T., Tyerman, A., & Jenkins, D. (1985) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.48.6.564 · Cited by 463
Witgen, B. M., Lifshitz, J., Smith, M. L., Schwarzbach, E., Liang, S., Grady, M. S., & Cohen, A. S. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.01.052 · Cited by 225
Self-citationTonic inhibition originates from synapses close to the soma
Soltész, I., Smetters, D. K., & Módy, I. (1995) · Neuron · doi:10.1016/0896-6273(95)90274-0 · Cited by 218
Vespa, P. M., O’Phelan, K. H., McArthur, D., Miller, C., Eliseo, M., Hirt, D., Glenn, T. C., & Hovda, D. A. (2007) · Critical Care Medicine · doi:10.1097/01.ccm.0000259466.66310.4f · Cited by 168
Adaptation of the fluid percussion injury model to the mouse
CARBONELL, W. S., MARIS, D. O., McCALL, T., & GRADY, M. S. (1998) · Journal of Neurotrauma · doi:10.1089/neu.1998.15.217 · Cited by 157 · cited 1×
“Furthermore, previous reports have documented complications using the MWM with mice (18).”
BackgroundMcKenna, M. C., Stevenson, J., Huang, X., & Hopkins, I. B. (2000) · Neurochemistry International · doi:10.1016/s0197-0186(00)00042-5 · Cited by 147
Therapeutic Use of Branched-Chain Amino Acids in Burn, Trauma, and Sepsis ,
Bandt, J. P. D., & Cynober, L. (2006) · Journal of Nutrition · doi:10.1093/jn/136.1.308s · Cited by 141
Yee, B. K., Hauser, J., Dolgov, V. V., Keist, R., Möhler, H., Rudolph, U., & Feldon, J. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03642.x · Cited by 134
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–148 of 148
Yao, X., Kong, X., Ren, J., Cui, Y., Chen, S., Cheng, J., Gao, J., Sun, J., Xu, X., Hu, W., et al. (2023) · European Journal of Neuroscience · doi:10.1111/ejn.16091 · Cited by 8
Wang, T., Wei, X.-Y., Yang, A.-A., Liu, Z., Wang, S.-Q., You, Y.-Y., Kuang, F., You, S., & Wu, M.-M. (2018) · Current Eye Research · doi:10.1080/02713683.2018.1510969 · Cited by 7
Peper, C. J., Kilgore, M. D., Jiang, Y., Xiu, Y., Xia, W., Wang, Y., Shi, M., Zhou, D., Dumont, A. S., Wang, X., et al. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14693 · Cited by 6
Shida, Y., Endo, H., Owada, S., Inagaki, Y., Sumiyoshi, H., Kamiya, A., Eto, T., & Tatemichi, M. (2021) · Scientific Reports · doi:10.1038/s41598-021-02591-7 · Cited by 6
Wang, J., Liu, B., Liu, J., Hou, Z., Xie, G., Xiong, X., & Yu, S. (2025) · Metabolites · doi:10.3390/metabo15120755 · Cited by 6
Time-Dependent Long-Term Effect of Memantine following Repetitive Mild Traumatic Brain Injury
Boucher, M. L., Conley, G. M., Morriss, N. J., Ospina-Mora, S., Qiu, J., Mannix, R., & Meehan, W. P., III (2024) · Journal of Neurotrauma · doi:10.1089/neu.2023.0423 · Cited by 6
Neural Markers of Vulnerability to Anxiety Outcomes after Traumatic Brain Injury
Popovitz, J., Mysore, S. P., & Adwanikar, H. (2020) · Journal of Neurotrauma · doi:10.1089/neu.2020.7320 · Cited by 6
Neuroprotection in Traumatic Brain Injury
Jain, K. K. (2011) · Humana Press eBooks · doi:10.1007/978-1-61779-049-2_4 · Cited by 6
Delcy, S. A. S., Farrugia, A. M., Nieves, I. A. D., O’Brien, C. A., Bennett, F. C., & Cohen, A. S. (2025) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2025.106178 · Cited by 5
Self-citationXiong, G., Jean, I., Farrugia, A. M., Metheny, H. E., Johnson, B. N., Cohen, N. A., & Cohen, A. S. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1339262 · Cited by 5
Self-citationCui, F., Li, H., Cao, Y., Wang, W., & Zhang, D. (2024) · Nutrients · doi:10.3390/nu16091284 · Cited by 5
Exploring cortical proteins underlying the relation of neuroticism to cognitive resilience
Grodstein, F., Yu, L., Jager, P. L. D., Levey, A. I., Seyfried, N. T., & Bennett, D. A. (2022) · Aging Brain · doi:10.1016/j.nbas.2022.100031 · Cited by 3
Sonnay, S., Christinat, N., Thévenet, J., Wiederkehr, A., Chakrabarti, A., & Masoodi, M. (2020) · Biomedicines · doi:10.3390/biomedicines8110487 · Cited by 3
Huang, J. V., Law, E. C. N., Karaman, İ., McCrickerd, K., Fogel, A. M., Chong, M. F., Daniel, L. M., Silveira, P. P., Chong, Y. S., Eriksson, J. G., et al. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.104111 · Cited by 3
Kim, J. H., Choo, Y.-H., Kim, M., Jeon, H., Jung, H.-W., Ha, E. J., Oh, J., Shim, Y., Kim, S. B., Jung, H.-G., et al. (2023) · Journal of Neurointensive Care · doi:10.32587/jnic.2023.00689 · Cited by 2
Use of oral squamous cell carcinoma: A discussion paper
Senevirathna, K., Jayawardana, N. U., Gamage, C. U., Perera, A. G. U., Jayasinghe, R. D., & Seneviratne, B. (2023) · International Health Trends and Perspectives · doi:10.32920/ihtp.v3i1.1676 · Cited by 3
Ubri, C., Farrugia, A. M., & Cohen, A. S. (2025) · Journal of Neurotrauma · doi:10.1089/neu.2025.0046 · Cited by 2
Self-citationMaekawa, K., Ohara, N., Higashibeppu, N., Kawamoto, M., & Ohta, T. (2025) · Clinical Nutrition · doi:10.1016/j.clnu.2025.09.013 · Cited by 2
LC‐MS‐based urine metabolomics analysis of chronic subdural hematoma for biomarker discovery
Sun, J., Ou, Y., Liu, X., Sun, H., Guo, Z., Qi, F., Lan, Y., Liu, W., & Sun, W. (2023) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.202200107 · Cited by 2
Bell, K. C., Chrysostomou, V., Karlsson, M., Jones, B. W., Williams, P. A., & Crowston, J. G. (2025) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2025.03.004 · Cited by 2
Nutrition in Traumatic Brain Injury: Focus on the Immune Modulating Supplements
Ayodele, T., Cordina, R., Stanislaw, P. A., & David, C. (2014) · InTech eBooks · doi:10.5772/57305 · Cited by 2
Nutrition as Medicine to Improve Outcomes in Adolescents Sustaining a Sports-related Concussion
Casazza, K., & Swanson‐Kimani, E. (2017) · Exploratory Research and Hypothesis in Medicine · doi:10.14218/erhm.2017.00029 · Cited by 2
Emerging Approaches for Regenerative Rehabilitation Following Traumatic Brain Injury
O’Donnell, J. C., Swanson, R. L., Wofford, K. L., Grovola, M. R., Purvis, E. M., Petrov, D., & Cullen, D. K. (2022) · Physiology in health and disease · doi:10.1007/978-3-030-95884-8_13 · Cited by 2
To, X. V., Mohamed, A. Z., Cumming, P. D., & Nasrallah, F. A. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1014081 · Cited by 2
Whole-Blood Metabolomics of a Rat Model of Repetitive Concussion
Khan, A. R., Zehra, S., Baranwal, A. K., Kumar, D., Ali, R., Javed, S., & Bhaisora, K. S. (2023) · Journal of Molecular Neuroscience · doi:10.1007/s12031-023-02162-7 · Cited by 1
Mathew, E., Jones, N., Dews, M., Neal, D., & Cohen, A. J. (2025) · Diseases · doi:10.3390/diseases13030076 · Cited by 1
Self-citationXu, L., Qu, C., Liu, Y., Zhao, X., Gu, R., Huang, Y., Wang, K., Xiong, M., & Liu, H. (2025) · Nutritional Neuroscience · doi:10.1080/1028415x.2025.2536037 · Cited by 1
The Gut Microbiome as a Modulator of Traumatic Brain Injury Pathology and Symptoms
Haar, C. V., Celorrio, M., Martens, K. M., Friess, S. H., Villapol, S., Urban, R. J., Pyles, R. B., Mychasiuk, R., Simon, D. W., & Dave, A. M. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.1337-25.2025 · Cited by 1
Sudargo, T., Hadi, H., Lestariana, W., & Kumara, A. (2016) · International Journal of Community Medicine and Public Health · doi:10.18203/2394-6040.ijcmph20162071 · Cited by 1
Novel Metabolic Substrates for Feeding the Injured Brain
White, H. T., Krüger, P., & Venkatesh, B. (2017) · Annual update in intensive care and emergency medicine · doi:10.1007/978-3-319-51908-1_27 · Cited by 1
Wasserman, T. H., & Mion, A. (2018) · Journal of Pediatric Neuropsychology · doi:10.1007/s40817-018-0050-y · Cited by 2
What Happens to Concussed Animals?
Victoroff, J. (2019) · Cambridge University Press eBooks · doi:10.1017/9781139696432.006
Role of nutraceuticals in the management of severe traumatic brain injury
Teegala, R. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820593-8.00005-7
Yao, X., Ren, J., Cui, Y., Chen, S., Cheng, J., Gao, J., Huang, X., Sun, J., Xu, X., Kong, X., et al. (2021) · doi:10.22541/au.163525012.23548218/v1
Amino Acids in the Treatment of Neurologic Disorders
Hartman, A. L. (2022) · doi:10.1093/med/9780197501207.003.0035
Amino Acids in the Treatment of Neurological Disorders
Hartman, A. L. (2016) · doi:10.1093/med/9780190497996.003.0035
Reichelt, A. C., & Dunkley, B. T. (2022) · doi:10.31234/osf.io/xa62p · Cited by 1
Les acides aminés branchés, un lien « essentiel » entre alimentation, horloge et sommeil ?
Seugnet, L. (2022) · Médecine du Sommeil · doi:10.1016/j.msom.2022.11.001
Brain trauma, ketogenic diets, and ketogenesis via enteral nutrition
White, H. T., & Heffernan, A. J. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-89834-8.00006-4
Lizogub, V. G., Tv, Z., Savchenko, O. V., & Tyravska, Y. V. (2013) · Likarska sprava · doi:10.31640/ls-2013-5-04
Role of Branched-Chain Amino Acids in Traumatic Brain Injury
Elsamman, K. (2024) · Nutritional neurosciences · doi:10.1007/978-981-97-6341-2_7
Elliott, J. E., Sicard, S. J., Olivo, C., Cunningham, H. A., Ekis, A. E., Powers, K., Brewer, J. S., D’Silva, J., Happ, S., Hildebrand, A. D., et al. (2025) · medRxiv · doi:10.1101/2025.02.22.25322722
Self-citationDickerman, R. D., Bennett, M. T., Mathew, E., & East, J. W. (2025) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2025.2558195
Mathew, E., Jones, N., Hernandez, K., Ortega, S. B., & Dickerman, R. D. (2025) · International Journal of Translational Medicine · doi:10.3390/ijtm5030042
Graß, T., Cosacak, I. M., Ordureau, A., Price, F. D., Kavali, S., Caldarelli, A., Qiao, M. N., Vardarajan, B. N., Paulo, J. A., Marass, M., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.19.706886 · Cited by 1
Wang, S., Guo, Y., Zhou, B., Li, M., Su, Q., Qiu, Y., Dong, Y., & Li, J. (2026) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2026.111830
Noninvasive Urinary Biomarkers for Early Diagnosis of Mild Traumatic Brain Injury
Cohen, A. S., Arbogast, K. B., Lee, Y. E., Johnson, B., Podolak, O. E., Master, C. L., Beauchamp, G. K., & Kimball, B. A. (2026) · Neurotrauma Reports · doi:10.1177/2689288x261464654
Self-citationYamaki, T., Oka, N., Higuchi, Y., Ito, D., & Kobayashi, S. (2026) · Neurology · doi:10.1212/wnl.0000000000218419
Metadata
- Authors
- Cole, J. T., Mitala, C. M., Kundu, S., Verma, A., Elkind, J. A., Nissim, I., & Cohen, A. S.
- Affiliations
- Division of Neurology and
- Children's Hospital of Philadelphia (US)
- Uniformed Services University of the Health Sciences (US)
- Johns Hopkins University (US)
- Corresponding author
- Cohen, Akiva S.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2009-12-29
- Volume
- 107
- Issue
- 1
- Pages
- 366-371
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2806733
- OpenAlex
- W2135865446
- Cited by
- 148
- References
- 28
- Citations by year
- 2026: 4 · 2025: 12 · 2024: 10 · 2023: 14 · 2022: 14 · 2021: 6 · 2020: 12 · 2019: 11 · 2018: 9 · 2017: 9 · 2016: 12 · 2015: 5 · 2014: 8 · 2013: 6 · 2012: 5
- FWCI
- 3.19
- Type
- journal article
- Language
- en
- Update notices
- correction (2010-02-02)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK053761)
- National Institute of Neurological Disorders and Stroke (R01NS069629, T32NS043126)
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD059288)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- branched-chain amino acids, traumatic brain injury, cognitive impairment, excitation-inhibition balance, hippocampus, glutamate synthesis, GABA, lateral fluid percussion injury, dietary intervention, branched-chain amino acid aminotransferase, branched-chain ketoacid dehydrogenase, glutamate dehydrogenase, glutamic acid decarboxylase, field excitatory postsynaptic potentials, concussion
- MeSH terms
- Amino Acids, Branched-Chain, Animals, Brain Injuries, Cognition Disorders, Diet, Hippocampus, Humans, Male, Mice, Inbred C57BL, Synaptic Transmission, Glutamic Acid, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
