The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland
Open accessAbstract
The mouse mammary gland develops postnatally under the control of female reproductive hormones. Estrogens and progesterone trigger morphogenesis by poorly understood mechanisms acting on a subset of mammary epithelial cells (MECs) that express their cognate receptors, estrogen receptor α (ERα) and progesterone receptor (PR). Here, we show that in the adult female, progesterone drives proliferation of MECs in two waves. The first, small wave, encompasses PR(+) cells and requires cyclin D1, the second, large wave, comprises mostly PR(−) cells and relies on the tumor necrosis factor (TNF) family member, receptor activator of NF-κB-ligand (RANKL). RANKL elicits proliferation by a paracrine mechanism. Ablation of RANKL in the mammary epithelium blocks progesterone-induced morphogenesis, and ectopic expression of RANKL in MECs completely rescues the PR −/− phenotype. Systemic administration of RANKL triggers proliferation in the absence of PR signaling, and injection of a RANK signaling inhibitor interferes with progesterone-induced proliferation. Thus, progesterone elicits proliferation by a cell-intrinsic and a, more important, paracrine mechanism.
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Writing Group for the Women's Health Initiative Investigators (2002) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.288.3.321 · Cited by 15,889
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Kong, Y.-Y., Yoshida, H., Sarosi, I., Tan, H.-L., Timms, E., Capparelli, C., Morony, S., Oliveira-dos-Santos, A. J., Van, G., Itie, A., et al. (1999) · Nature · doi:10.1038/16852 · Cited by 3,351
Diehl, J. A., Zindy, F., & Sherr, C. J. (1997) · Genes & Development · doi:10.1101/gad.11.8.957 · Cited by 746
Cited by
Progesterone action in endometrial cancer, endometriosis, uterine fibroids, and breast cancer
Kim, J. J., Kurita, T., & Bulun, S. E. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1043 · Cited by 520
Phenotypic and functional characterisation of the luminal cell hierarchy of the mammary gland
Shehata, M., Teschendorff, A., Sharp, G., Novcic, N., Russell, I. A., Avril, S., Prater, M., Eirew, P., Caldas, C., Watson, C. J., et al. (2012) · Breast Cancer Research · doi:10.1186/bcr3334 · Cited by 306
RANKL/RANK/OPG system beyond bone remodeling: involvement in breast cancer and clinical perspectives
Infante, M., Fabi, A., Cognetti, F., Gorini, S., Caprio, M., & Fabbri, A. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-1001-2 · Cited by 180
Constitutive activation of RANK disrupts mammary cell fate leading to tumorigenesis
Pellegrini, P., Cordero, A., Gallego, M. I., Dougall, W. C., Purificación, M., Pujana, M. A., & Gonzalez-Suarez, E. (2013) · Stem Cells · doi:10.1002/stem.1454 · Cited by 52
Benítez, S., Cordero, A., Santamaría, P. G., Redondo-Pedraza, J., Rocha, A. S., Collado-Solé, A., Jimenez, M., Sanz-Moreno, A., Yoldi, G., Santos, J. C., et al. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.04.022 · Cited by 41
Metadata
- Authors
- Beleut, M., Rajaram, R. D., Caikovski, M., Ayyanan, A., Germano, D., Choi, Y., Schneider, P., & Brisken, C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2010-01-28
- Volume
- 107
- Issue
- 7
- Pages
- 2989-2994
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2159610509
- Cited by
- 307
- References
- 3
- FWCI
- 15.59
- Type
- journal article
- Language
- en
- Open access
- green
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- Beleut, M., Rajaram, R. D., Caikovski, M., Ayyanan, A., Germano, D., Choi, Y., Schneider, P., & Brisken, C. (2010). Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0915148107
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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