The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Identification of the β cell antigen targeted by a prevalent population of pathogenic CD8 + T cells in autoimmune diabetes
Open accessAbstract
Type 1 diabetes is an autoimmune disease in which autoreactive T cells attack and destroy the insulin-producing pancreatic β cells. CD8 + T cells are essential for this β cell destruction, yet their specific antigenic targets are largely unknown. Here, we reveal that the autoantigen targeted by a prevalent population of pathogenic CD8 + T cells in nonobese diabetic mice is islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP). Through tetramer technology, IGRP-reactive T cells are readily detected in islets and peripheral blood directly ex vivo . The human IGRP gene maps to a diabetes susceptibility locus, suggesting that IGRP also may be an antigen for pathogenic T cells in human type 1 diabetes and, thus, a new, potential target for diagnostic and therapeutic approaches.
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Innate immunity and intestinal microbiota in the development of Type 1 diabetes
Wen, L., Ley, R. E., Volchkov, P. Y., Stranges, P. B., Avanesyan, L., Stonebraker, A. C., Hu, C., Wong, F. S., Szot, G. L., Bluestone, J. A., et al. (2008) · Nature · doi:10.1038/nature07336 · Cited by 1,921
THE NOD MOUSE: A Model of Immune Dysregulation
Anderson, M. S., & Bluestone, J. A. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115643 · Cited by 1,113
Fallarino, F., Grohmann, U., You, S., McGrath, B. C., Cavener, D. R., Vacca, C., Orabona, C., Bianchi, R., Belladonna, M. L., Volpi, C., et al. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.11.6752 · Cited by 1,047
Self-citationThe cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes
Wenzlau, J. M., Juhl, K., Yu, L., Moua, O., Sarkar, S. A., Gottlieb, P., Rewers, M., Eisenbarth, G. S., Jensen, J., Davidson, H. W., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705894104 · Cited by 1,014
Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice
Nakayama, M., Abiru, N., Moriyama, H., Babaya, N., Liu, E., Miao, D., Yu, L., Wegmann, D. R., Hutton, J. C., Elliott, J. F., et al. (2005) · Nature · doi:10.1038/nature03523 · Cited by 758
Metadata
- Authors
- Lieberman, S. M., Evans, A. M., Han, B., Takaki, T., Vinnitskaya, Y., Caldwell, J. A., Serreze, D. V., Shabanowitz, J., Hunt, D. F., Nathenson, S. G., Santamaria, P., & DiLorenzo, T. P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2003-06-18
- Volume
- 100
- Issue
- 14
- Pages
- 8384-8388
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2146776232
- Cited by
- 388
- References
- 28
- FWCI
- 14.06
- Type
- journal article
- Language
- en
- Open access
- green
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- Lieberman, S. M., Evans, A. M., Han, B., Takaki, T., Vinnitskaya, Y., Caldwell, J. A., Serreze, D. V., Shabanowitz, J., Hunt, D. F., Nathenson, S. G., Santamaria, P., & DiLorenzo, T. P. (2003). Identification of the β cell antigen targeted by a prevalent population of pathogenic CD8 + T cells in autoimmune diabetes. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0932778100
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