The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Ca V 3.1 is a tremor rhythm pacemaker in the inferior olive
Open accessAbstract
The rhythmic motor pathway activation by pacemaker neurons or circuits in the brain has been proposed as the mechanism for the timing of motor coordination, and the abnormal potentiation of this mechanism may lead to a pathological tremor. Here, we show that the potentiation of Ca V 3.1 T-type Ca 2+ channels in the inferior olive contributes to the onset of the tremor in a pharmacological model of essential tremor. After administration of harmaline, 4- to 10-Hz synchronous neuronal activities arose from the IO and then propagated to cerebellar motor circuits in wild-type mice, but those rhythmic activities were absent in mice lacking Ca V 3.1 gene. Intracellular recordings in brain-stem slices revealed that the Ca V 3.1-deficient inferior olive neurons lacked the subthreshold oscillation of membrane potentials and failed to trigger 4- to 10-Hz rhythmic burst discharges in the presence of harmaline. In addition, the selective knockdown of Ca V 3.1 gene in the inferior olive by sh RNA efficiently suppressed the harmaline-induced tremor in wild-type mice. A mathematical model constructed based on data obtained from patch-clamping experiments indicated that harmaline could efficiently potentiate Ca V 3.1 channels by changing voltage-dependent responsiveness in the hyperpolarizing direction. Thus, Ca V 3.1 is a molecular pacemaker substrate for intrinsic neuronal oscillations of inferior olive neurons, and the potentiation of this mechanism can be considered as a pathological cause of essential tremor.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Moreover, T-type calcium channels are a powerful mechanism by which the IO regulates cerebellar output [269].”
From Consensus Paper: Pathological Role of the Cerebellum in Autism (2012) · cites this paper as [269]
Citations
Cites
Thalamocortical oscillations in the sleeping and aroused brain
Steriade, M., McCormick, D. A., & Sejnowski, T. J. (1993) · Science · doi:10.1126/science.8235588 · Cited by 3,564
Internal models in the cerebellum
Wolpert, D. M., Miall, R. C., & Kawato, M. (1998) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(98)01221-2 · Cited by 2,469
Molecular Physiology of Low-Voltage-Activated T-type Calcium Channels
Perez‐Reyes, E. (2003) · Physiological Reviews · doi:10.1152/physrev.00018.2002 · Cited by 1,655
Normal and pathological oscillatory communication in the brain
Schnitzler, A., & Groß, J. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1650 · Cited by 1,283
Sleep and arousal: thalamocortical mechanisms
McCormick, D. A., & Bal, T. (1997) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.20.1.185 · Cited by 1,267
Llinas, R. H., & Yarom, Y. (1981) · The Journal of Physiology · doi:10.1113/jphysiol.1981.sp013763 · Cited by 972
Self-citationCore assessment program for surgical interventional therapies in Parkinson's disease (CAPSIT-PD)
Defer, G., Widner, H., Mari�, R.-M., Rémy, P., & Levivier, M. (1999) · Movement Disorders · doi:10.1002/1531-8257(199907)14:4 · Cited by 863
Talley, E. M., Cribbs, L. L., Lee, J., Daud, A. N., Perez‐Reyes, E., & Bayliss, D. A. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-06-01895.1999 · Cited by 790
Low-Threshold Calcium Currents in Central Nervous System Neurons
Huguenard, J. R. (1996) · Annual Review of Physiology · doi:10.1146/annurev.ph.58.030196.001553 · Cited by 767
Dynamic organization of motor control within the olivocerebellar system
Welsh, J. P., Lang, E. J., Suglhara, I., & Llinás, R. (1995) · Nature · doi:10.1038/374453a0 · Cited by 685
Cited by
Sorted by citations
Zamponi, G. W., Striessnig, J., Koschak, A., & DOLPHIN, A. C. (2015) · Pharmacological Reviews · doi:10.1124/pr.114.009654 · Cited by 1,158
“They also show resistance to chemically induced tremor (Park et al., 2010), but the latter is accompanied by increased cerebellar atrophy and a loss of motor coordination (Chang et al., 2011).”
BackgroundConsensus Paper: Pathological Role of the Cerebellum in Autism
Fatemi, S. H., Aldinger, K. A., Ashwood, P., Bauman, M. L., Blaha, C. D., Blatt, G. J., Chauhan, A., Chauhan, V., Dager, S. R., Dickson, P. E., et al. (2012) · The Cerebellum · doi:10.1007/s12311-012-0355-9 · Cited by 723
“Moreover, T-type calcium channels are a powerful mechanism by which the IO regulates cerebellar output [269].”
BackgroundSpatiotemporal firing patterns in the cerebellum
Zeeuw, C. I. D., Hoebeek, F. E., Bosman, L. W. J., Schonewille, M., Witter, L., & Koekkoek, S. K. E. (2011) · Nature reviews. Neuroscience · doi:10.1038/nrn3011 · Cited by 411
The oscillating central network of Essential tremor
Raethjen, J., & Deuschl, G. (2011) · Clinical Neurophysiology · doi:10.1016/j.clinph.2011.09.024 · Cited by 188
“The neurons in the inferior olive carry a set of special Calcium channels that are capable of producing rhythmic discharges at the tremor frequencies (Park et al., 2010).”
Apartis, E., Blancher, A., Meissner, W. G., Guyant‐Maréchal, L., Maltête, D., de Broucker, T., Legrand, A. P., Bouzenada, H., Tran-Thanh, H., Sallansonnet-Froment, M., et al. (2012) · Neurology · doi:10.1212/wnl.0b013e318271f7ff · Cited by 178
Metadata
- Authors
- Park, Y.-G., Park, H.-Y., Lee, C. J., Choi, S., Jo, S., Choi, H., Kim, Y.-H., Shin, H.-S., Llinas, R. R., & Kim, D.
- Affiliations
- Korea Advanced Institute of Science and Technology (KR)
- Korea Institute of Science and Technology (KR)
- New York University (US)
- Department of Physiology and Neuroscience, New York University School of Medicine, New York, NY 10016; and
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2010-05-24
- Volume
- 107
- Issue
- 23
- Pages
- 10731-10736
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2890811
- OpenAlex
- W2075318347
- Cited by
- 142
- References
- 45
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 3 · 2023: 8 · 2022: 14 · 2021: 9 · 2020: 8 · 2019: 15 · 2018: 7 · 2017: 8 · 2016: 2 · 2015: 12 · 2014: 12 · 2013: 9 · 2012: 16
- FWCI
- 6.48
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Science and Technology
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (NS 13742, P01NS013742)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- Cav3.1, T-type calcium channels, inferior olive, essential tremor, pathological tremor, pacemaker neurons, harmaline, neural oscillations, shRNA knockdown
- MeSH terms
- Animals, Cell Line, Disease Models, Animal, Harmaline, Humans, Male, Mice, Inbred C57BL, Olivary Nucleus, Tremor, Mice, Knockout, Calcium Channels, T-Type, RNA Interference, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
