The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
A tumor-suppressing mechanism in Drosophila involving cell competition and the Hippo pathway
Open accessAbstract
Mutant larvae for the Drosophila gene lethal giant larva (lgl) develop neoplastic tumors in imaginal discs. However, lgl mutant clones do not form tumors when surrounded by wild-type tissue, suggesting the existence of a tumor-suppressing mechanism. We have investigated the tumorigenic potential of lgl mutant cells by generating wing compartments that are entirely mutant for lgl and also inducing clones of various genetic combinations of lgl − cells. We find that lgl − compartments can grow indefinitely but lgl − clones are eliminated by cell competition. lgl mutant cells may form tumors if they acquire constitutive activity of the Ras pathway ( lgl − UAS-ras V12 ), which confers proliferation advantage through inhibition of the Hippo pathway. Yet, the majority of lgl − UAS-ras V12 clones are eliminated in spite of their high proliferation rate. The formation of a tumor requires in addition the formation of a microenvironment that allows mutant cells to evade cell competition.
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Gateff, E. (1978) · Science · doi:10.1126/science.96525 · Cited by 461 · cited 1×
“As reported long ago (13), lgl mutant larvae are unable to pupate and remain a long time in the culture medium to finally die as gigantic larvae when they are 12–13 d old.”
BackgroundIgaki, T., Pastor-Pareja, J. C., Aonuma, H., Miura, M., & Xu, T. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.01.002 · Cited by 295
Cited by
The Hippo pathway: regulators and regulations.
Yu, F.-X., & Guan, K.-L. (2013) · Genes & Development · doi:10.1101/gad.210773.112 · Cited by 1,231
Aerobic glycolysis tunes YAP/TAZ transcriptional activity
Enzo, E., Santinon, G., Pocaterra, A., Aragona, M., Bresolin, S., Forcato, M., Grifoni, D., Pession, A., Zanconato, F., Guzzo, G., et al. (2015) · The EMBO Journal · doi:10.15252/embj.201490379 · Cited by 414
Sun, G., & Irvine, K. D. (2011) · Developmental Biology · doi:10.1016/j.ydbio.2010.11.036 · Cited by 219
Tumor suppression by cell competition through regulation of the Hippo pathway
Chen, C.-L., Schroeder, M. C., Kango-Singh, M., Tao, C., & Halder, G. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113882109 · Cited by 187
Ajuba Family Proteins Link JNK to Hippo Signaling
Sun, G., & Irvine, K. D. (2013) · Science Signaling · doi:10.1126/scisignal.2004324 · Cited by 153
Metadata
- Authors
- Menéndez, J., Pérez-Garijo, A., Calleja, M., & Morata, G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2010-08-02
- Volume
- 107
- Issue
- 33
- Pages
- 14651-14656
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W20679206
- Cited by
- 176
- References
- 2
- FWCI
- 5.44
- Type
- journal article
- Language
- en
- Open access
- green
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