The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Bitter taste receptors and α-gustducin regulate the secretion of ghrelin with functional effects on food intake and gastric emptying
Open accessAbstract
Ghrelin is a hunger hormone with gastroprokinetic properties but the factors controlling ghrelin secretion from the stomach are unknown. Bitter taste receptors (T2R) and the gustatory G proteins, α-gustducin (gust) and α-transducin, are expressed in the gut and are involved in the chemosensation of nutrients. This study aimed to investigate whether T2R-agonists affect ( i ) ghrelin release via α-gustducin and ( ii ) food intake and gastric emptying via the release of ghrelin. The mouse stomach contains two ghrelin cell populations: cells containing octanoyl and desoctanoyl ghrelin, which were colocalized with α-gustducin and α-transducin, and cells staining for desoctanoyl ghrelin. Gavage of T2R-agonists increased plasma octanoyl ghrelin levels in WT mice but the effect was partially blunted in gust −/− mice. Intragastric administration of T2R-agonists increased food intake during the first 30 min in WT but not in gust −/− and ghrelin receptor knockout mice. This increase was accompanied by an increase in the mRNA expression of agouti-related peptide in the hypothalamus of WT but not of gust −/− mice. The temporary increase in food intake was followed by a prolonged decrease (next 4 h), which correlated with an inhibition of gastric emptying. The delay in emptying, which was partially counteracted by ghrelin, was not mediated by cholecystokinin and GLP-1 but involved a direct inhibitory effect of T2R-agonists on gastric contractility. This study is unique in providing functional evidence that activation of bitter taste receptors stimulates ghrelin secretion. Modulation of endogenous ghrelin levels by tastants may provide novel therapeutic applications for the treatment of weight -and gastrointestinal motility disorders.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Further, activation of bitter taste receptors stimulates ghrelin secretion (62) and, therefore, affects the vagus nerve.”
From Vagus Nerve as Modulator of the Brain–Gut Axis in Psychiatric and Inflammatory Disorders (2018) · cites this paper as [62]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Ghrelin is a growth-hormone-releasing acylated peptide from stomach
Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H., & Kangawa, K. (1999) · Nature · doi:10.1038/45230 · Cited by 8,479
Ghrelin induces adiposity in rodents
Tschöp, M., Smiley, D. L., & Heiman, M. L. (2000) · Nature · doi:10.1038/35038090 · Cited by 3,949
A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans
Cummings, D. E., Purnell, J. Q., Frayo, R. S., Schmidova, K., Wisse, B. E., & Weigle, D. S. (2001) · Diabetes · doi:10.2337/diabetes.50.8.1714 · Cited by 2,940 · cited 3×
“bodies: rabbit anti-octanoyl ghrelin [1-8] (Ab5004, in-house developed), rabbit anti-desoctanoyl ghrelin [1-17] (gift from C.”
MethodT2Rs Function as Bitter Taste Receptors
Chandrashekar, J. V., Mueller, K. L., Hoon, M. A., Adler, E., Feng, L., Guo, W., Zuker, C. S., & Ryba, N. J. P. (2000) · Cell · doi:10.1016/s0092-8674(00)80706-0 · Cited by 1,402
The Molecular Receptive Ranges of Human TAS2R Bitter Taste Receptors
Meyerhof, W., Batram, C., Kühn, C., Brockhoff, A., Chudoba, E., Bufe, B., Appendino, G., & Behrens, M. (2009) · Chemical Senses · doi:10.1093/chemse/bjp092 · Cited by 1,146
Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1.
Jang, H.-J., Kokrashvili, Z., Theodorakis, M. J., Carlson, O. D., Kim, B.-J., Zhou, J., Kim, H. H., Xu, X., Chan, S. L., Juhaszova, M., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706890104 · Cited by 995 · cited 2×
“bodies: rabbit anti-octanoyl ghrelin [1-8] (Ab5004, in-house developed), rabbit anti-desoctanoyl ghrelin [1-17] (gift from C.”
MethodT1R3 and gustducin in gut sense sugars to regulate expression of Na + -glucose cotransporter 1
Margolskee, R. F., Dyer, J., Kokrashvili, Z., Salmon, K. S. H., Ilegems, E., Daly, K., Maillet, E. L., Ninomiya, Y., Mosinger, B., & Shirazi-Beechey, S. P. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706678104 · Cited by 882
Ghrelin Modulates Brain Activity in Areas that Control Appetitive Behavior
Malik, S., McGlone, F., Bedrossian, D., & Dagher, A. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.03.007 · Cited by 677
Transduction of bitter and sweet taste by gustducin
Wong, G. T., Gannon, K. S., & Margolskee, R. F. (1996) · Nature · doi:10.1038/381796a0 · Cited by 669
Wu, S.-Z., Rozengurt, N., Yang, M. Y., Young, S. H., Sinnett‐Smith, J. W., & Rozengurt, E. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.042617699 · Cited by 493
Cited by
Sorted by citations
Items 201–300 of 315
Bitarafan, V., Fitzgerald, P. C. E., Little, T. J., Meyerhof, W., Wu, T., Horowitz, M., & Feinle‐Bisset, C. (2019) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm19036 · Cited by 17
Robino, A., Rosso, N., Guerra, M., Corleone, P., Casagranda, B., Giraudi, P. J., Tiribelli, C., Simeth, C., Monica, F., Bianca, M. L., et al. (2021) · Appetite · doi:10.1016/j.appet.2021.105595 · Cited by 17
Taste Receptor Gene Expression Outside the Gustatory System
Behrens, M., Prandi, S., & Meyerhof, W. (2014) · Topics in medicinal chemistry · doi:10.1007/7355_2014_79 · Cited by 16
Mang, D., Toyama, T., Yamagishi, T., Sun, J., Purba, E. R., Endo, H., Matthews, M. M., Ito, K., Nagata, S., & Sato, R. (2023) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2023.103927 · Cited by 17
Taste and the Gastrointestinal tract: from physiology to potential therapeutic target for obesity
Sarnelli, G., Annunziata, G., Magno, S., Oriolo, C., Savastano, S., & Colao, A. (2019) · International Journal of Obesity Supplements · doi:10.1038/s41367-019-0012-6 · Cited by 16
Teramoto, H., Shimizu, T., Yogo, H., Nishimiya, Y., Hori, S., Kosugi, T., & Nakayama, S. (2014) · Physiological Reports · doi:10.1002/phy2.187 · Cited by 16
Anyone for an aperitif? Yes, but only a Braulio DOC with its certified proteome
Fasoli, E., D’Amato, A., Citterio, A., & Righetti, P. G. (2012) · Journal of Proteomics · doi:10.1016/j.jprot.2012.04.020 · Cited by 15
Negri, R., Morini, G., & Greco, L. (2011) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3182309641 · Cited by 15
GIORGIO, R. D., Mazzoni, M., Vallorani, C., Latorre, R., Bombardi, C., Bacci, M. L., Forni, M., Falconi, M., Sternini, C., & Clavenzani, P. (2016) · PLoS ONE · doi:10.1371/journal.pone.0148954 · Cited by 15
The role of nutrient sensing in the metabolic changes after gastric bypass surgery
Steensels, S., Lannoo, M., Avau, B., Laermans, J., Vancleef, L., Farré, R., Verbeke, K., & Depoortere, I. (2016) · Journal of Endocrinology · doi:10.1530/joe-16-0541 · Cited by 15
Self-citationNutrient‐sensing components of the mouse stomach and the gastric ghrelin cell
Nunez‐Salces, M., Li, H., Feinle‐Bisset, C., Young, R. L., & Page, A. J. (2020) · Neurogastroenterology & Motility · doi:10.1111/nmo.13944 · Cited by 15
Turner, A., Chijoff, E., Veysey, M. J., Keely, S., Scarlett, C. J., Lucock, M. D., & Beckett, E. (2019) · Journal of Nutrition & Intermediary Metabolism · doi:10.1016/j.jnim.2019.100106 · Cited by 16
Nunez‐Salces, M., Li, H., Christie, S., & Page, A. J. (2020) · Nutrients · doi:10.3390/nu12092493 · Cited by 15
Lee, S.-H., Ko, H. M., Jee, W., Kim, H., Chung, W., & Jang, H.-J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043682 · Cited by 17
Itoigawa, A., Nakagita, T., & Toda, Y. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312654 · Cited by 13
Is gastrointestinal motility related to alkaloids of Charred Semen Arecae?
Zhang, F., Yang, P., He, Q., Dong, X., & Zhang, S. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.112825 · Cited by 13
Nutritional Implications of Taste and Smell Dysfunction
Lee, J. C. L., Tucker, R. M., Tan, S., Running, C. A., Jones, J. B., & Mattes, R. D. (2015) · Wiley eBooks · doi:10.1002/9781118971758.ch37 · Cited by 13
Multi-scale simulations of membrane proteins: The case of bitter taste receptors
Suku, E., Fierro, F., Giorgetti, A., Alfonso‐Prieto, M., & Carloni, P. (2017) · Journal of Science Advanced Materials and Devices · doi:10.1016/j.jsamd.2017.03.001 · Cited by 12
Mazzoni, M., Bonaldo, A., Gatta, P. P., Vallorani, C., Latorre, R., Canova, M., & Clavenzani, P. (2015) · Fish Physiology and Biochemistry · doi:10.1007/s10695-015-0031-3 · Cited by 12
Expression of Bitter Taste Receptors in the Human Skin In Vitro
Nowakowska, E. R. E. (2015) · Journal of Clinical Research & Bioethics · doi:10.4172/2155-9627.1000218 · Cited by 12
Liu, M., Qian, W., Subramaniyam, S., Liu, S., & Xin, W. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.172951 · Cited by 12
Ghrelin Receptors Enhance Fat Taste Responsiveness in Female Mice
Calder, A. N., Yu, T., Dahir, N. S., Sun, Y., & Gilbertson, T. A. (2021) · Nutrients · doi:10.3390/nu13041045 · Cited by 12
Tuft cell integration of luminal states and interaction modules in tissues
Schneider, C. (2021) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-021-02630-2 · Cited by 13
Chen, L., Li, H., Teng, J., Wang, Z., Qu, X., Chen, Z., Cai, X., Zeng, H., Bai, Z., Li, J., et al. (2025) · Advanced Science · doi:10.1002/advs.202504961 · Cited by 16
Novel approaches to anti-obesity drug discovery with gut hormones over the past 10 years
Rose, F., Bloom, S. R., & Tan, T. (2019) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2019.1646243 · Cited by 11
Turner, A., Veysey, M. J., Keely, S., Scarlett, C. J., Lucock, M. D., & Beckett, E. (2021) · Nutrients · doi:10.3390/nu13020571 · Cited by 11
Biased signaling: A viable strategy to drug ghrelin receptors for the treatment of obesity
Nagi, K., & Habib, A. M. (2021) · Cellular Signalling · doi:10.1016/j.cellsig.2021.109976 · Cited by 11
Characterization and phylogeny of bitter taste receptor genes (Tas2r) in Squamata
Zhong, H., Shang, S., Zhang, H., Chen, J., Wu, X., & Zhang, H. (2019) · Genetica · doi:10.1007/s10709-019-00056-4 · Cited by 10
Distinct Cell Types With the Bitter Receptor Tas2r126 in Different Compartments of the Stomach
Widmayer, P., Partsch, V., Pospiech, J., Kusumakshi, S., Boehm, U., & Breer, H. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00032 · Cited by 10
Rezaie, P., Bitarafan, V., Rose, B. D., Lange, K. M., Rehfeld, J. F., Horowitz, M., & Feinle‐Bisset, C. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgac182 · Cited by 10
Mazzoni, M., Bombardi, C., Vallorani, C., Sirri, F., GIORGIO, R. D., Caio, G., Grandis, A., Sternini, C., & Clavenzani, P. (2016) · Poultry Science · doi:10.3382/ps/pew057 · Cited by 10
Merigo, F., Boschi, F., Lasconi, C., Benati, D., & Sbarbati, A. (2016) · European Journal of Histochemistry · doi:10.4081/ejh.2016.2557 · Cited by 9
Expression of Jejunal Taste Receptors in Women with Morbid Obesity
Bertran, L., Portillo-Carrasquer, M., Martínez, S., Aguilar, C., López-Dupla, M., Riesco, D., Binetti, J., Vives, M., Sabench, F., Castillo, D. D., et al. (2021) · Nutrients · doi:10.3390/nu13072437 · Cited by 9
Paniagua, M., Villagómez‐Estrada, S., Crespo, F. J., Pérez, J. F., Arı́s, A., Devant, M., & Solà‐Oriol, D. (2023) · Animals · doi:10.3390/ani13060967 · Cited by 9
Possible role of type 1 and type 2 taste receptors on obesity-induced inflammation
Koh, G. Y., Rowling, M. J., & Pritchard, S. K. (2022) · Nutrition Reviews · doi:10.1093/nutrit/nuac007 · Cited by 10
Expression of taste signal transduction molecules in the caecum of common marmosets
Gonda, S., Matsumura, S., Saito, S., Go, Y., & Imai, H. (2013) · Biology Letters · doi:10.1098/rsbl.2013.0409 · Cited by 9
Role of Bitter Taste Receptors in Regulating Gastric Accommodation in Guinea Pigs
Harada, Y., Koseki, J., Sekine, H., Fujitsuka, N., & Kobayashi, H. (2019) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.118.256008 · Cited by 9
Yoshida, Y., Nishimura, S., Tabata, S., & Kawabata, F. (2021) · World s Poultry Science Journal · doi:10.1080/00439339.2022.2007437 · Cited by 8
Sun, J., Zhang, W., Cui, Z., Pan, Y., Smagghe, G. J., Zhang, L., Wickham, J. D., Sun, J., & Mang, D. (2024) · Pest Management Science · doi:10.1002/ps.8285 · Cited by 8
Effect of motilin receptor activation on food intake and food timing
Deloose, E., Biesiekierski, J. R., Vanheel, H., Depoortere, I., & Tack, J. F. (2018) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqx044 · Cited by 8
Self-citationThe effect of two weeks ingestion of a bitter tastant mixture on energy intake in overweight females
Peters, H. P. F., Koppenol, W. P., Schuring, E. A. H., Gouka, R. J., Mela, D. J., & Blom, W. A. M. (2016) · Appetite · doi:10.1016/j.appet.2016.08.013 · Cited by 9
Editorial: Extra-Oral Taste Receptors: Function, Disease and Evolution
ZhuGe, R., Roura, E., & Behrens, M. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.607134 · Cited by 8
Tu, K., Zhou, M., Tan, J. J., Markos, L., Cloud, C., Zhou, M., Hayashi, N., Rawson, N. E., Margolskee, R. F., & Wang, H. (2023) · Physiology & Behavior · doi:10.1016/j.physbeh.2023.114446 · Cited by 8
Hunter, D. C., Jones, V. S., HEDDERLEY, D. I., & Jaeger, S. R. (2018) · Food Research International · doi:10.1016/j.foodres.2018.10.051 · Cited by 7
Hassan, L., Newman, L. P., Keast, R., Danaher, J., & Biesiekierski, J. R. (2022) · Appetite · doi:10.1016/j.appet.2022.106336 · Cited by 7
Beyond flavour to the gut and back
Kadohisa, M. (2015) · Flavour · doi:10.1186/s13411-015-0047-8 · Cited by 7
Schiano, E., Iannuzzo, F., Stornaiuolo, M., Guerra, F., Tenore, G. C., & Novellino, E. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052596 · Cited by 6
Rapid expansion and specialization of the TAS2R bitter taste receptor family in amphibians
Higgins, K. W., Itoigawa, A., Toda, Y., Bellott, D. W., Anderson, R., Márquez, R., & Weng, J. (2025) · PLoS Genetics · doi:10.1371/journal.pgen.1011533 · Cited by 6
Andryszkiewicz, W., Chmielewska, M., Ciecierska, J., Lenkiewicz, P., Marciniak, W., Raczycka, W., Wojno, A., Kulbacka, J., Niewiński, P., & Bieżuńska-Kusiak, K. (2025) · Nutrients · doi:10.3390/nu17162619 · Cited by 6
Al-Ghurayr, N. K., Al-Mowalad, A. M., Omar, U. M., Ashi, H. M., Al‐Shehri, S. S., AlShaikh, A. A., AlHarbi, S. M., & Alsufiani, H. M. (2023) · Journal of Diabetes Research · doi:10.1155/2023/7559078 · Cited by 6
Chiurazzi, M., Conno, B. D., Lauro, M. D., Guida, B., Nasti, G., Schiano, E., Stornaiuolo, M., Tenore, G. C., Colantuoni, A., & Novellino, E. (2023) · Nutrients · doi:10.3390/nu15245033 · Cited by 6
Mazzoni, M., Karunaratne, T. B., Sirri, F., Petracci, M., GIORGIO, R. D., Sternini, C., & Clavenzani, P. (2018) · Poultry Science · doi:10.3382/ps/pey279 · Cited by 6
Sun, S., Corbeels, K., Desmet, L., Segers, A., Wang, Q., der Schueren, B. V., & Depoortere, I. (2020) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2020.108468 · Cited by 6
Self-citationKrasteva‐Christ, G., Lin, W., & Tizzano, M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.23827-3 · Cited by 5
Dar, S. A., Bhushan, A., & Gupta, P. (2020) · Springer eBooks · doi:10.1007/978-981-15-5917-4_12 · Cited by 5
Săvulescu-Fiedler, I., Gurghean, A. L., & Siliste, R. (2022) · Journal of Medicine and Life · doi:10.25122/jml-2022-0096 · Cited by 5
Furness, J. B., & Cottrell, J. J. (2017) · Animal Production Science · doi:10.1071/an17276 · Cited by 6
Steroid Hormones Are Potent and Putatively Endogenous Activators of Human Bitter Taste Receptors
Lang, T., Ferri, F., Ziegler, F., Pizio, A. D., & Behrens, M. (2026) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.70172 · Cited by 4
Emerging Role of Taste Receptors, Entero-Endocrine Cells in Type 2 Diabetes and Metabolic Disorders
Khin, K. L. S., Youssefi, S., Yang, Q., Page, A. J., Nateri, A. S., Eldeghaidy, S., Young, R. L., & IDRIS, I. R. (2026) · Nutrients · doi:10.3390/nu18050759 · Cited by 5
Gustatory system and implications for feeding in fish
Morais, S., & Kasumyan, A. O. (2025) · Elsevier eBooks · doi:10.1016/b978-0-323-90873-3.00012-9 · Cited by 4
Segú, H., Jalševac, F., Lores, M., Beltrán‐Debón, R., Terra, X., Pinent, M., Ardèvol, A., Rodríguez‐Gallego, E., & Blay, M. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c02408 · Cited by 4
Cheled-Shoval, S. L., Uni, Z., & Scanes, C. G. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819770-7.00051-7 · Cited by 4
Role of Dietary Free Glutamate in Gastrointestinal Function
Zai, H., Somekawa, S., & Uneyama, H. (2012) · Journal of Nutrition & Food Sciences · doi:10.4172/2155-9600.1000125 · Cited by 4
Chen, K., Liang, X., Yi, H., Yu, G., & Wu, Q. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1660529 · Cited by 3
Vilalta, A., Descamps‐Solà, M., Sierra‐Cruz, M., Miguéns‐Gómez, A., Beltrán‐Debón, R., Rodríguez‐Gallego, E., Pinent, M., Blay, M., Ardèvol, A., & Terra, X. (2026) · Food & Function · doi:10.1039/d5fo03241e · Cited by 3
Belloir, C., Gautier, A., Karolkowski, A., Delompré, T., Jeannin, M., Moitrier, L., Neiers, F., & Briand, L. V. (2024) · Protein Expression and Purification · doi:10.1016/j.pep.2024.106643 · Cited by 3
Conti, F., Olivotto, I., Cattaneo, N., Pavanello, M., Şener, İ., Antonucci, M., Chemello, G., Gioacchini, G., & Zarantoniello, M. (2024) · Animals · doi:10.3390/ani14172588 · Cited by 3
Current and future clinical applications of ghrelin
Vriese, C. D., Perret, J., & Delporte, C. (2014) · Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) · Cited by 3
Jung, H. Y., Kim, W., Yoo, D. Y., Nam, S. M., Kim, J. W., Choi, J. H., Yoon, Y. S., Kim, H. Y., & Hwang, I. K. (2014) · Journal of Veterinary Science · doi:10.4142/jvs.2014.15.4.459 · Cited by 3
Les inhibiteurs du goût sucré : perspectives thérapeutiques
Sigoillot, M., Laffitte, A., Neiers, F., & Briand, L. V. (2015) · Cahiers de Nutrition et de Diététique · doi:10.1016/j.cnd.2015.02.003 · Cited by 3
Taste Hedonics Influence the Disposition of Fat by Modulating Gastric Emptying in Rats
Saitou, K., Lees, J. N., & Tordoff, M. G. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090717 · Cited by 3
Fu, M., Collins, C. L., Henman, D. J., & Roura, E. (2015) · Animal Production Science · doi:10.1071/anv55n12ab033 · Cited by 3
Herness, S. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-382026-6.00026-9 · Cited by 4
Zhao, D., Boey, L., Weltens, N., Biesiekierski, J. R., Iven, J., Depoortere, I., Tack, J. F., & Oudenhove, L. V. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.06.010 · Cited by 3
Self-citationBiochemistry of Human Bitter Taste Receptors
Upadhyaya, J. D., Singh, N., Bhullar, R. P., & Chelikani, P. (2017) · doi:10.1002/9781118590263.ch1 · Cited by 3
Bitter Taste Receptors 38 and 46 Regulate Intestinal Peristalsis
Camillo, L., Pollastro, F., Talmon, M., & Fresu, L. G. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26052092 · Cited by 5
Kuwahara, A. (2025) · Biomedical Research · doi:10.2220/biomedres.46.233 · Cited by 2
Ribichini, E., Scalese, G., Mocci, C., Amicis, N. D., & Severi, C. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1738562 · Cited by 2
Antonova, O., & Spasova, V. (2022) · Acta Medica Bulgarica · doi:10.2478/amb-2022-0003 · Cited by 2
Sosoranga, E. R., Verbeure, W., Geysen, H., Thijs, T., Matthys, C., Depoortere, I., & Tack, J. F. (2023) · Nutrients · doi:10.3390/nu15194264 · Cited by 2
Self-citationHewedy, W. A., & Darwish, I. E. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176802 · Cited by 2
Talley, N. J. (2011) · Yearbook of Gastroenterology · doi:10.1016/j.ygas.2011.07.078 · Cited by 2
Les récepteurs du goût dans le poumon : intéressants ou anecdotiques ?
Grassin‐Delyle, S., Abrial, C., Brollo, M., Naline, E., & Devillier, P. (2014) · Revue de Pneumologie Clinique · doi:10.1016/j.pneumo.2013.11.008 · Cited by 2
Wooding, S., & Ramirez, V. A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.23871-6 · Cited by 2
Airway smooth muscle as a target in asthma : new insights into bronchorelaxation and hyperreactivity
Manson, M. L. (2015) · Figshare · Cited by 2
Ciullo, D., & Dotson, C. (2015) · Chemosensory Perception · doi:10.1007/s12078-015-9190-y · Cited by 1
Tenore, G. C., Bottone, S., Riccio, G., Badolati, N., Stornaiuolo, M., & Novellino, E. (2018) · Journal of Nutrition & Food Sciences · doi:10.4172/2155-9600.1000664 · Cited by 1
Iven, J., Biesiekierski, J. R., Zhao, D., Tack, J. F., & Oudenhove, L. V. (2020) · Nutritional Neuroscience · doi:10.1080/1028415x.2020.1781326 · Cited by 1
Self-citationJackson, R. S. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-85263-0.00011-9 · Cited by 1
Petzel, E. A., Acharya, S., Bailey, E., & Brake, D. W. (2021) · Journal of Dairy Science · doi:10.3168/jds.2020-19461 · Cited by 1
Implications of type 1 and type 2 taste receptors on obesity-induced inflammation
Koh, G. Y., & Wang, Y. (2022) · Journal of Food Bioactives · doi:10.31665/jfb.2022.18323 · Cited by 1
Ares, M. S. (2017) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3qb9vk44 · Cited by 1
Plant Proteomics and Food and Beverage Analysis via CPLL Capture
Righetti, P. G., & Boschetti, E. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-401734-4.00005-1
Modulation of the Bitter Taste to Reduce Calorie Intake
Kim, H. M. (2015) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm15142
Cellular and molecular mechanisms of action of bitter compounds: recent knowledge and perspective
Nagy, M., & Mučaji, P. (2016) · Česká a slovenská farmacie · doi:10.36290/csf.2016.029
Novel Enteroendocrine Cell Receptors Regulating Incretin Secretion and Glucose Homeostasis
Flock, G. B. (2012) · TSpace (University of Toronto)
Physiological Aspects of Bitterness
Behrens, M., & Meyerhof, W. (2017) · doi:10.1002/9781118590263.ch2
Obesity induced dysfunction of gastric vagal afferent signalling.
Kentish, S. J. (2013) · Adelaide Research & Scholarship (AR&S) (University of Adelaide)
Bitter Taste, Rising New Functions and Significance of Extra-oral Expressions
Ki, S.-Y., & Kim, K. (2018) · International Journal of Oral Biology · doi:10.11620/ijob.2018.43.3.113
Metadata
- Authors
- Janssen, S., Laermans, J., Verhulst, P.-J., Thijs, T., Tack, J., & Depoortere, I.
- Affiliations
- UCLouvain (BE)
- Vanderbilt University (US)
- Corresponding author
- Depoortere, Inge
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2011-01-18
- Volume
- 108
- Issue
- 5
- Pages
- 2094-2099
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3033292
- OpenAlex
- W2122332643
- Cited by
- 317
- References
- 35
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 9 · 2023: 12 · 2022: 23 · 2021: 29 · 2020: 28 · 2019: 19 · 2018: 23 · 2017: 30 · 2016: 20 · 2015: 32 · 2014: 21 · 2013: 21 · 2012: 23
- FWCI
- 11.25
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fonds Wetenschappelijk Onderzoek
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- ghrelin, bitter taste receptors, alpha-gustducin, ghrelin secretion, dietary intake, gastric emptying, agouti-related protein, gastric contractility, hunger hormones, body weight regulation, gastrointestinal motility disorders
- MeSH terms
- Animals, Base Sequence, Cholecystokinin, Feeding Behavior, Gastric Emptying, Male, Mice, Inbred C57BL, Muscle Contraction, Muscle, Smooth, Radioimmunoassay, Taste Buds, Transducin, Polymerase Chain Reaction, DNA Primers, Mice, Glucagon-Like Peptide 1, Ghrelin, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review