The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Sublethal exposure to crude oil during embryonic development alters cardiac morphology and reduces aerobic capacity in adult fish
Open accessAbstract
Exposure to high concentrations of crude oil produces a lethal syndrome of heart failure in fish embryos. Mortality is caused by cardiotoxic polycyclic aromatic hydrocarbons (PAHs), ubiquitous components of petroleum. Here, we show that transient embryonic exposure to very low concentrations of oil causes toxicity that is sublethal, delayed, and not counteracted by the protective effects of cytochrome P450 induction. Nearly a year after embryonic oil exposure, adult zebrafish showed subtle changes in heart shape and a significant reduction in swimming performance, indicative of reduced cardiac output. These delayed physiological impacts on cardiovascular performance at later life stages provide a potential mechanism linking reduced individual survival to population-level ecosystem responses of fish species to chronic, low-level oil pollution.
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Citations
Cites
Incardona, J. P., Day, H. L., Collier, T. K., & Scholz, N. L. (2006) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2006.09.018 · Cited by 319
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Cited by
Deepwater Horizon crude oil impacts the developing hearts of large predatory pelagic fish
Incardona, J. P., Gardner, L. D., Linbo, T. L., Brown, T. L., Esbaugh, A. J., Mager, E. M., Stieglitz, J. D., French, B. L., Labenia, J. S., Laetz, C. A., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1320950111 · Cited by 422
Self-citationCrude Oil Impairs Cardiac Excitation-Contraction Coupling in Fish
Brette, F., Machado, B., Cros, C., Incardona, J. P., Scholz, N. L., & Block, B. A. (2014) · Science · doi:10.1126/science.1242747 · Cited by 310
Self-citationYoung, A., Kochenkov, V., McIntyre, J. K., Stark, J. D., & Coffin, A. B. (2018) · Scientific Reports · doi:10.1038/s41598-018-21209-z · Cited by 35
Meade, E. B., Iwanowicz, L. R., Neureuther, N., LeFevre, G. H., Kolpin, D. W., Zhi, H., Meppelink, S. M., Lane, R. F., Schmoldt, A., Mohaimani, A., et al. (2023) · Science of The Total Environment · doi:10.1016/j.scitotenv.2022.159069 · Cited by 12
Metadata
- Authors
- Hicken, C. E., Linbo, T. L., Baldwin, D. H., Willis, M. L., Myers, M. S., Holland, L., Larsen, M., Stekoll, M. S., Rice, S. D., Collier, T. K., Scholz, N. L., & Incardona, J. P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2011-04-11
- Volume
- 108
- Issue
- 17
- Pages
- 7086-7090
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1985716327
- Cited by
- 334
- References
- 1
- FWCI
- 10.50
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Sublethal exposure to crude oil during embryonic development alters cardiac morphology and reduces aerobic capacity in adult fish. https://app.cochat.ai/papers/10.1073/pnas.1019031108
- The paper
- Hicken, C. E., Linbo, T. L., Baldwin, D. H., Willis, M. L., Myers, M. S., Holland, L., Larsen, M., Stekoll, M. S., Rice, S. D., Collier, T. K., Scholz, N. L., & Incardona, J. P. (2011). Sublethal exposure to crude oil during embryonic development alters cardiac morphology and reduces aerobic capacity in adult fish. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1019031108
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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