The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Identification and characterization of a functional mitochondrial angiotensin system
Open accessAbstract
The renin-angiotensin (Ang) system regulates multiple physiological functions through Ang II type 1 and type 2 receptors. Prior studies suggest an intracellular pool of Ang II that may be released in an autocrine manner upon stretch to activate surface membrane Ang receptors. Alternatively, an intracellular renin-Ang system has been proposed, with a primary focus on nuclear Ang receptors. A mitochondrial Ang system has not been previously described. Here we report that functional Ang II type 2 receptors are present on mitochondrial inner membranes and are colocalized with endogenous Ang. We demonstrate that activation of the mitochondrial Ang system is coupled to mitochondrial nitric oxide production and can modulate respiration. In addition, we present evidence of age-related changes in mitochondrial Ang receptor expression, i.e., increased mitochondrial Ang II type 1 receptor and decreased type 2 receptor density that is reversed by chronic treatment with the Ang II type 1 receptor blocker losartan. The presence of a functional Ang system in human mitochondria provides a foundation for understanding the interaction between mitochondria and chronic disease states and reveals potential therapeutic targets for optimizing mitochondrial function and decreasing chronic disease burden with aging.
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Cites
Nitric oxide synthase activity in mitochondria
Ghafourifar, P., & Richter, C. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01397-5 · Cited by 567
Mitochondrial localization of ERα and ERβ in human MCF7 cells
Chen, J. Q., Delannoy, M., Cooke, C., & Yager, J. D. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00508.2003 · Cited by 272
Self-citation
Cited by
Cardiac Aging: From Molecular Mechanisms to Significance in Human Health and Disease
Dai, D.-F., Chen, T., Johnson, S. C., Szeto, H., & Rabinovitch, P. S. (2012) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.4179 · Cited by 334
Brain Renin–Angiotensin System at the Intersect of Physical and Cognitive Frailty
Cosarderelioglu, C., Nidadavolu, L. S., George, C. J., Oh, E. S., Bennett, D. A., Walston, J. D., & Abadir, P. M. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.586314 · Cited by 134
Self-citationThe Angiotensin AT2 Receptor: From a Binding Site to a Novel Therapeutic Target
Steckelings, U. M., Widdop, R. E., Sturrock, E. D., Lubbe, L., Hussain, T., Kaschina, E., Unger, T., Hallberg, A., Carey, R. M., & Sumners, C. (2022) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000281 · Cited by 97
Self-citationKim, N., Jung, Y., Nam, M., Sun Kang, M., Lee, M. K., Cho, Y., Choi, E.-K., Hwang, G.-S., & Soo Kim, H. (2017) · Scientific Reports · doi:10.1038/s41598-017-09675-3 · Cited by 39
Liao, X., Xiao, J., Li, S.-H., Xiao, L.-L., Cheng, B., Fu, X.-B., Cui, T., & Liu, H.-W. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.07.006 · Cited by 21
Metadata
- Authors
- Abadir, P. M., Foster, D. B., Crow, M., Cooke, C. A., Rucker, J. J., Jain, A., Smith, B. J., Burks, T. N., Cohn, R. D., Fedarko, N. S., Carey, R. M., O’Rourke, B., & Walston, J. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2011-08-18
- Volume
- 108
- Issue
- 36
- Pages
- 14849-14854
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2083985618
- Cited by
- 279
- References
- 2
- FWCI
- 16.41
- Type
- journal article
- Language
- en
- Open access
- green
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