The teleost agouti-related protein 2 gene is an ohnolog gone missing from the tetrapod genome
Open accessAbstract
A central question in evolutionary genomics is how morphological differences between taxa arise from differences in gene repertoire. Answers require rigorous orthology assignments. Recent work (1) illuminated the mechanism of background adaptation in teleost fishes by investigating the function of agouti-related protein 2 (agrp2), a gene so far found only in teleosts.
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Teleosts have several Agouti-related genes due to the teleost specific genome duplication.
“Due to the teleost specific genome duplication, teleosts have several Agouti-related genes (29–31)”
From Agouti and BMP signaling drive a naturally occurring fate conversion of melanophores to leucophores in zebrafish (2025) · cites this paper as [31]
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Huang, D., Kapadia, E. H., Liang, Y., Shriver, L. P., Dai, S., Patti, G. J., Humbel, B. M., Laudet, V., & Parichy, D. M. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2424180122 · Cited by 15 · see citing works
- Authors
- Braasch, I., & Postlethwait, J. H.
- Affiliations
- University of Oregon (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2011-03-15
- Volume
- 108
- Issue
- 13
- Pages
- E47-8
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3069192
- OpenAlex
- W2130582854
- Cited by
- 36
- References
- 0
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 4 · 2016: 3 · 2014: 2 · 2013: 2 · 2012: 6
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Center for Research Resources (R01RR020833)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Keywords
- teleost genomes, ohnologs, gene loss, gene duplication, comparative genomics, fish evolution
- MeSH terms
- Animals, Biological Evolution, Fishes, Genome, Protein Isoforms, Gene Duplication, Agouti-Related Protein
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