Regulation of angiogenesis and choroidal neovascularization by members of microRNA-23∼27∼24 clusters
Open accessAbstract
MicroRNAs (miRNAs) modulate complex physiological and pathological processes by repressing expression of multiple components of cellular regulatory networks. Here we demonstrate that miRNAs encoded by the miR-23∼27∼24 gene clusters are enriched in endothelial cells and highly vascularized tissues. Inhibition of miR-23 and miR-27 function by locked nucleic acid-modified anti-miRNAs represses angiogenesis in vitro and postnatal retinal vascular development in vivo. Moreover, miR-23 and miR-27 are required for pathological angiogenesis in a laser-induced choroidal neovascularization mouse model. MiR-23 and miR-27 enhance angiogenesis by promoting angiogenic signaling through targeting Sprouty2 and Sema6A proteins, which exert antiangiogenic activity. Manipulating miR-23/27 levels may have important therapeutic implications in neovascular age-related macular degeneration and other vascular disorders.
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miR-23-24-27 clusters are abundantly expressed in endothelial cells and highly vascularized tissues, targeting endothelial junction proteins to protect vascular integrity through functional regulation of endothelial cell junctions.
“As early as 2011, a study discovered that miR-23-24-27 clusters are abundantly expressed in endothelial cells and highly vascularized tissues, targeting a multitude of endothelial junction proteins to protect vascular integrity through the functional regulation of endothelial cell junctions.”
From Recent advances of miR-23 in human diseases and growth development (2025) · cites this paper as [42]
The two isoforms of miR-23 can facilitate angiogenesis and influence endothelial cell apoptosis by directly targeting Sprouty2, but they have different effects on endothelial cell function.
“Research has found that the two isoforms of miR-23 can facilitate angiogenesis and influence endothelial cell apoptosis by directly targeting Sprouty2 [42,43], but they have different effects on endothelial cell function.”
From Recent advances of miR-23 in human diseases and growth development (2025) · cites this paper as [42]
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References 45 · Cited by 341
- Authors
- Zhou, Q., Gallagher, R., Ufret-Vincenty, R., Li, X., Olson, E. N., & Wang, S.
- Affiliations
- Departments of aOphthalmology,
- Molecular Biology, and
- The University of Texas Southwestern Medical Center (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2011-05-02
- Volume
- 108
- Issue
- 20
- Pages
- 8287-8292
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3100947
- OpenAlex
- W2160554864
- Cited by
- 341
- References
- 45
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 14 · 2023: 12 · 2022: 7 · 2021: 21 · 2020: 21 · 2019: 24 · 2018: 20 · 2017: 39 · 2016: 18 · 2015: 27 · 2014: 38 · 2013: 43 · 2012: 31
- FWCI
- 13.60
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Welch Foundation (I-0025)
- American Heart Association
- Research to Prevent Blindness (EY020799)
- University of Texas Southwestern Medical Center
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R01HL093039)
- National Eye Institute (P30EY020799, EY020799, R01EY021862)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Keywords
- miR-23, miR-27, angiogenesis, choroidal neovascularization, pathological angiogenesis, retinal vascular development, endothelial cells, Sprouty2, SEMA6A, neovascular age-related macular degeneration, laser-induced choroidal neovascularization
- MeSH terms
- Animals, Endothelium, Vascular, Multigene Family, Humans, Retinal Vessels, Neovascularization, Physiologic, Choroidal Neovascularization, MicroRNAs, Systems Biology, Mice
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