The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Integration of Runx and Smad regulatory signals at transcriptionally active subnuclear sites
Open accessAbstract
Runx factors control lineage commitment and are transcriptional effectors of Smad signaling. Genetic defects in these pathways interfere with normal development. The in situ localization of Runx and Smad proteins must impact the mechanisms by which these proteins function together in gene regulation. We show that the integration of Runx and Smad signals is mediated by in situ interactions at specific foci within the nucleus. Activated Smads are directed to these subnuclear foci only in the presence of Runx proteins. Smad–Runx complexes are associated in situ with the nuclear matrix, and this association requires the intranuclear targeting signal of Runx factors. The convergence of Smad and Runx proteins at these sites supports transcription as reflected by BrUTP labeling and functional cooperativity between the proteins. Thus, Runx-mediated intranuclear targeting of Smads is critical for the integration of two distinct pathways essential for fetal development.
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Wang, Q., Stacy, T., Binder, M., Marin-Padilla, M., Sharpe, A. H., & Speck, N. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.8.3444 · Cited by 1,178
Cbfa2 is required for the formation of intra-aortic hematopoietic clusters
North, T., Gu, T.-L., Stacy, T., Wang, Q., Howard, L., Binder, M., Marín-Padilla, M., & Speck, N. A. (1999) · Development · doi:10.1242/dev.126.11.2563 · Cited by 662
Ito, Y. (1999) · Genes to Cells · doi:10.1046/j.1365-2443.1999.00298.x · Cited by 179
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Self-citationTGF-β Signaling from Receptors to Smads
Hata, A., & Chen, Y.-G. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a022061 · Cited by 888
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Zaidi, S. K., Sullivan, A. J., Medina, R., Ito, Y., van Wijnen, A. J., Stein, J. L., Lian, J. B., & Stein, G. S. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600073 · Cited by 398
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Metadata
- Authors
- Zaidi, S. K., Sullivan, A. J., van Wijnen, A. J., Stein, J. L., Stein, G. S., & Lian, J. B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2002-06-11
- Volume
- 99
- Issue
- 12
- Pages
- 8048-8053
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2070678884
- Cited by
- 198
- References
- 3
- FWCI
- 6.80
- Type
- journal article
- Language
- en
- Open access
- green
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- Zaidi, S. K., Sullivan, A. J., van Wijnen, A. J., Stein, J. L., Stein, G. S., & Lian, J. B. (2002). Integration of Runx and Smad regulatory signals at transcriptionally active subnuclear sites. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.112664499
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