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T helper type 1 lymphocytes drive inflammation in human atherosclerotic lesions
Open accessAbstract
Atherosclerotic lesions are infiltrated by macrophages and T lymphocytes, potentially reactive to pathogens. We studied in vivo activated T lymphocytes that infiltrate atherosclerotic plaques of Helicobacter pylori-infected patients with or without anti-Chlamydia pneumoniae antibodies. In all atherosclerotic lesions, T helper type 1 (Th1) cells were predominant.C. pneumoniae-specific T cells were detected only in the plaques of anti-C. pneumoniae seropositive patients, whereas H. pylori-specific T cells were found in the gastric mucosa but not in the plaques of the same patients. Plaque-derived Th1 cells expressed cytotoxicity, proapoptotic activity, and help for monocyte tissue factor production. Although multifactorial, atherosclerosis can be regarded as a Th1-driven immunopathological condition.
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Cited by
INFLAMMATION AND ATHEROSCLEROSIS
Hansson, G. K., Robertson, A.-K. L., & Söderberg-Nauclér, C. (2006) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathol.1.110304.100100 · Cited by 1,046
Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice
Steffens, S., Veillard, N. R., Arnaud, C., Pelli, G., Burger, F., Staub, C., Zimmer, A., Frossard, J.-L., & Mach, F. (2005) · Nature · doi:10.1038/nature03389 · Cited by 472
Innate immunity and inflammation in ageing: a key for understanding age-related diseases
Licastro, F., Candore, G., Lio, D., Porcellini, E., Colonna-Romano, G., Franceschi, C., & Caruso, C. (2005) · Immunity & Ageing · doi:10.1186/1742-4933-2-8 · Cited by 453
Disruption of TGF-β signaling in T cells accelerates atherosclerosis
Robertson, A.-K. L., Rudling, M., Zhou, X., Gorelik, L., Flavell, R. A., & Hansson, G. K. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18607 · Cited by 441
Endothelial Cell-Specific NF-κB Inhibition Protects Mice from Atherosclerosis
Gareus, R., Kotsaki, E., Xanthoulea, S., van der Made, I., Gijbels, M. J. J., Kardakaris, R., Polykratis, A., Kollias, G., de Winther, M. P. J., & Pasparakis, M. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.08.016 · Cited by 386
Metadata
- Authors
- Benagiano, M., Azzurri, A., Ciervo, A., Amedei, A., Tamburini, C., Ferrari, M., Telford, J. L., Baldari, C. T., Romagnani, S., Cassone, A., D'Elios, M. M., & Del Prete, G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2003-05-09
- Volume
- 100
- Issue
- 11
- Pages
- 6658-6663
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2038121986
- Cited by
- 159
- References
- 0
- FWCI
- 4.47
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: T helper type 1 lymphocytes drive inflammation in human atherosclerotic lesions. https://app.cochat.ai/papers/10.1073/pnas.1135726100
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- Benagiano, M., Azzurri, A., Ciervo, A., Amedei, A., Tamburini, C., Ferrari, M., Telford, J. L., Baldari, C. T., Romagnani, S., Cassone, A., D'Elios, M. M., & Del Prete, G. (2003). T helper type 1 lymphocytes drive inflammation in human atherosclerotic lesions. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1135726100
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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