The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Cancer resistance in the blind mole rat is mediated by concerted necrotic cell death mechanism
Open accessAbstract
Blind mole rats Spalax(BMR) are small subterranean rodents common in the Middle East. BMR is distinguished by its adaptations to life underground, remarkable longevity (with a maximum documented lifespan of 21 y), and resistance to cancer. Spontaneous tumors have never been observed in spalacids. To understand the mechanisms responsible for this resistance, we examined the growth of BMR fibroblasts in vitro of the species Spalax judaei and Spalax golani. BMR cells proliferated actively for 7–20 population doublings, after which the cells began secreting IFN-β, and the cultures underwent massive necrotic cell death within 3 d. The necrotic cell death phenomenon was independent of culture conditions or telomere shortening. Interestingly, this cell behavior was distinct from that observed in another long-lived and cancer-resistant African mole rat,Heterocephalus glaber, the naked mole rat in which cells display hypersensitivity to contact inhibition. Sequestration of p53 and Rb proteins using SV40 large T antigen completely rescued necrotic cell death. Our results suggest that cancer resistance of BMR is conferred by massive necrotic response to overproliferation mediated by p53 and Rb pathways, and triggered by the release of IFN-β. Thus, we have identified a unique mechanism that contributes to cancer resistance of this subterranean mammal extremely adapted to life underground.
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Cites
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,218 · cited 1×
“This mechanism resembles oncogene-induced senescence of human cells, where cells enter irreversible arrest in response to hyperproliferative signals, such as expression of activated oncogenes (16, 17).”
BackgroundGenome sequencing reveals insights into physiology and longevity of the naked mole rat
Kim, E. B., Fang, X., Fushan, A. A., Huang, Z., Lobanov, A. V., Han, L., Marino, S. M., Sun, X., Turanov, A. A., Yang, P., et al. (2011) · Nature · doi:10.1038/nature10533 · Cited by 576
Liu, G., Parant, J. M., Lang, G., Chau, P., Chavez-Reyes, A., El-Naggar, A. K., Multani, A., Chang, S., & Lozano, G. (2004) · Nature Genetics · doi:10.1038/ng1282 · Cited by 325
Cited by
Abegglen, L. M., Caulin, A. F., Chan, A., Lee, K., Robinson, R., Campbell, M. S., Kiso, W. K., Schmitt, D. L., Waddell, P. J., Bhaskara, S., et al. (2015) · JAMA · doi:10.1001/jama.2015.13134 · Cited by 485
Cancer across the tree of life: cooperation and cheating in multicellularity
Aktipis, C. A., Boddy, A. M., Jansen, G., Hibner, U., Hochberg, M. E., Maley, C. C., & Wilkinson, G. S. (2015) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2014.0219 · Cited by 466
How ageing processes influence cancer
de Magalhães, J. P. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3497 · Cited by 367
Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax
Fang, X., Nevo, E., Han, L., Levanon, E. Y., Zhao, J., Avivi, A., Larkin, D., Jiang, X., Feranchuk, S., Zhu, Y., et al. (2014) · Nature Communications · doi:10.1038/ncomms4966 · Cited by 136
Self-citationTransposon-triggered innate immune response confers cancer resistance to the blind mole rat
Zhao, Y., Oreskovic, E., Zhang, Q., Lu, Q., Gilman, A., Lin, Y. S., He, J., Zheng, Z., Lu, J. Y., Lee, J., et al. (2021) · Nature Immunology · doi:10.1038/s41590-021-01027-8 · Cited by 99
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Metadata
- Authors
- Gorbunova, V., Hine, C., Tian, X., Ablaeva, J., Gudkov, A. V., Nevo, E., & Seluanov, A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2012-11-05
- Volume
- 109
- Issue
- 47
- Pages
- 19392-19396
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2104164098
- Cited by
- 163
- References
- 3
- FWCI
- 4.40
- Type
- journal article
- Language
- en
- Open access
- green
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- Gorbunova, V., Hine, C., Tian, X., Ablaeva, J., Gudkov, A. V., Nevo, E., & Seluanov, A. (2012). Cancer resistance in the blind mole rat is mediated by concerted necrotic cell death mechanism. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1217211109
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