Role for the kinase SGK1 in stress, depression, and glucocorticoid effects on hippocampal neurogenesis

Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants

Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., et al. (2003) · Science · doi:10.1126/science.1083328 · Cited by 4,321

Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus

van Praag, H., Kempermann, G., & Gage, F. H. (1999) · Nature Neuroscience · doi:10.1038/6368 · Cited by 3,880

Adult hippocampal neurogenesis buffers stress responses and depressive behaviour

Snyder, J. S., Soumier, A., Brewer, M., Pickel, J., & Cameron, H. A. (2011) · Nature · doi:10.1038/nature10287 · Cited by 1,473

Allele-specific FKBP5 DNA demethylation mediates gene–childhood trauma interactions

Klengel, T., Mehta, D., Anacker, C., Rex-Haffner, M., Pruessner, J. C., Pariante, C. M., Pace, T. W. W., Mercer, K. B., Mayberg, H. S., Bradley, B., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3275 · Cited by 1,447

Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression

David, D. J., Samuels, B. A., Rainer, Q., Wang, J.-W., Marsteller, D., Mendez, I., Drew, M., Craig, D. A., Guiard, B. P., Guilloux, J.-P., et al. (2009) · Neuron · doi:10.1016/j.neuron.2009.04.017 · Cited by 1,267

Prenatal stress produces learning deficits associated with an inhibition of neurogenesis in the hippocampus

Lemaire, V., Koehl, M., Le Moal, M., & Abrous, D. N. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.20.11032 · Cited by 1,044

Enriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesis

Brown, J., Cooper‐Kuhn, C. M., Kempermann, G., Van Praag, H., Winkler, J., Gage, F. H., & Kuhn, H. G. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02647.x · Cited by 809

Differential Control of Learning and Anxiety along the Dorsoventral Axis of the Dentate Gyrus

Kheirbek, M. A., Drew, L. J., Burghardt, N. S., Costantini, D. O., Tannenholz, L., Ahmari, S. E., Zeng, H., Fenton, A. A., & Hen, R. (2013) · Neuron · doi:10.1016/j.neuron.2012.12.038 · Cited by 713

Antidepressants increase neural progenitor cells in the human hippocampus

Boldrini, M., Underwood, M. D., Hen, R., Rosoklija, G. B., Dwork, A. J., John Mann, J., & Arango, V. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.75 · Cited by 686

Adrenal hormones suppress cell division in the adult rat dentate gyrus

Gould, E., Cameron, H. A., Daniels, D., Woolley, C. S., & McEwen, B. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-09-03642.1992 · Cited by 652

The effects of peripheral hormone responses to exercise on adult hippocampal neurogenesis

Kraemer, R. R., & Kraemer, B. R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1202349 · Cited by 43

Caveolin-1 Regulates Genomic Action of the Glucocorticoid Receptor in Neural Stem Cells

Peffer, M. E., Chandran, U. R., Luthra, S., Volonté, D., Galbiati, F., Garabedian, M. J., Monaghan, A. P., & DeFranco, D. B. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.01121-13 · Cited by 40

Acute stress enhances the expression of neuroprotection- and neurogenesis-associated genes in the hippocampus of a mouse restraint model

Sannino, G., Pasqualini, L., Ricciardelli, E., Montilla, P., Soverchia, L., Ruggeri, B., Falcinelli, S., Renzi, A., Ludka, C., Kirchner, T., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.7225 · Cited by 40

Comparison of chronic physical and emotional social defeat stress effects on mesocorticolimbic circuit activation and voluntary consumption of morphine

Cooper, S., Kechner, M., Caraballo-Pérez, D., Kaska, S., Robison, A. J., & Mazei‐Robison, M. S. (2017) · Scientific Reports · doi:10.1038/s41598-017-09106-3 · Cited by 38

Chronic Social Stress Affects Synaptic Maturation of Newly Generated Neurons in the Adult Mouse Dentate Gyrus

Chen, C., Huang, C., & Hsu, K. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv097 · Cited by 41

Regular exercise and creatine supplementation prevent chronic mild stress-induced decrease in hippocampal neurogenesis via Wnt/GSK3β/β-catenin pathway

Leem, Y., Kato, M., & Chang, H. (2018) · Physical Activity and Nutrition · doi:10.20463/jenb.2018.0009 · Cited by 37

Endurance and resistance training mitigate the negative consequences of depression on synaptic plasticity through different molecular mechanisms

Kang, J., Wang, Y., & Wang, D. (2019) · International Journal of Neuroscience · doi:10.1080/00207454.2019.1679809 · Cited by 36

The therapeutic potential of traditional Chinese medicine in depression: Targeting adult hippocampal neurogenesis

Feng, L., Xing, H., & Zhang, K. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.153980 · Cited by 38

The role of AQP4 in the pathogenesis of depression, and possible related mechanisms

Genel, O., Pariante, C. M., & Borsini, A. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.08.232 · Cited by 37

Reduced expression of the glucocorticoid receptor in the hippocampus of patients with drug‐resistant temporal lobe epilepsy and comorbid depression

D’Alessio, L., Mesarosova, L., Anink, J. J., Kochen, S. S., Solis, P. C. L., Oddo, S. A., Konopka, H., Iyer, A. M., Mühlebner, A., Lucassen, P. J., et al. (2020) · Epilepsia · doi:10.1111/epi.16598 · Cited by 34

Stress and Its Impact on the Transcriptome

Girgenti, M. J., Pothula, S., & Newton, S. S. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.12.011 · Cited by 33

SGK1, a Critical Regulator of Immune Modulation and Fibrosis and a Potential Therapeutic Target in Chronic Graft-Versus-Host Disease

Lu, R., Zhang, Y., Zhao, H., Guo, R., Jiang, Z., & Guo, R. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.822303 · Cited by 35

MicroRNAs in Psychological Stress Reactions and Their Use as Stress-Associated Biomarkers, Especially in Human Saliva

Wiegand, C., Savelsbergh, A., & Heusser, P. (2017) · Biomedicine Hub · doi:10.1159/000481126 · Cited by 37

Programming for increased expression of hippocampal GAD67 mediated the hypersensitivity of the hypothalamic–pituitary–adrenal axis in male offspring rats with prenatal ethanol exposure

Lu, J., Jiao, Z., Yu, Y., Zhang, C., He, X., Li, Q., Xu, D., & Wang, H. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0663-1 · Cited by 34

AMPK Mediates Glucocorticoids Stress-Induced Downregulation of the Glucocorticoid Receptor in Cultured Rat Prefrontal Cortical Astrocytes

Yuan, S., Liu, J., Zhou, J., Lü, W., Zhou, H.-Y., Long, L., Hu, Z., Ni, L., Wang, Y., Chen, J., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0159513 · Cited by 34

The HPA Axis in the Pathogenesis and Treatment of Depressive Disorders: Integrating Clinical and Molecular Findings

Baumeister, D., Lightman, S. L., & Pariante, C. M. (2016) · Psychopathology Review · doi:10.5127/pr.034413 · Cited by 33

Maternal mRNA input of growth and stress-response-related genes in cichlids in relation to egg size and trophic specialization

Ahi, E. P., Singh, P., Lecaudey, L. A., Gessl, W., & Sturmbauer, C. (2018) · EvoDevo · doi:10.1186/s13227-018-0112-3 · Cited by 33

NPTX2 is a key component in the regulation of anxiety

Chang, S., Bok, P., Tsai, C., Sun, C., Liu, H., Deussing, J. M., & Huang, G. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0091-z · Cited by 30

Mineralocorticoid Receptors, Neuroinflammation and Hypertensive Encephalopathy

Brocca, M. E., Pietranera, L., de Kloet, E. R., & Nicola, A. F. D. (2018) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-018-0610-9 · Cited by 32

Adult-born neurons from the dorsal, intermediate, and ventral regions of the longitudinal axis of the hippocampus exhibit differential sensitivity to glucocorticoids

Levone, B. R., Codagnone, M. G., Moloney, G. M., Nolan, Y. M., Cryan, J. F., & O’Leary, O. F. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0848-8 · Cited by 33

Oxidative stress downstream of mTORC1 but not AKT causes a proliferative defect in cancer cells resistant to PI3K inhibition

Dermit, M., Casado, P., Rajeeve, V., Wilkes, E. H., Foxler, D. E., Campbell, H., Critchlow, S. E., Sharp, T. V., Gribben, J. G., Unwin, R. J., et al. (2016) · Oncogene · doi:10.1038/onc.2016.435 · Cited by 32

Neuron stem cell NLRP6 sustains hippocampal neurogenesis to resist stress-induced depression

Tang, C., Wang, Q., Shen, J., Wang, C., Ding, H., Wen, S., Yang, F., Jiao, R., Wu, X., Li, J., et al. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.03.010 · Cited by 31

SGK1/FOXO3 Signaling in Hypothalamic POMC Neurons Mediates Glucocorticoid-Increased Adiposity

Deng, Y., Xiao, Y., Yuan, F., Liu, Y., Jiang, X., Deng, J., Fejes‐Tóth, G., Náray‐Fejes‐Tóth, A., Chen, S., Chen, Y., et al. (2018) · Diabetes · doi:10.2337/db17-1069 · Cited by 32

Minireview: the impact of antenatal therapeutic synthetic glucocorticoids on the developing fetal brain

Peffer, M. E., Zhang, J. Y., Umfrey, L., Rudine, A. C., Monaghan, A. P., & DeFranco, D. B. (2015) · Molecular Endocrinology · doi:10.1210/me.2015-1042 · Cited by 30

Stress Modifies the Expression of Glucocorticoid-Responsive Genes by Acting at Epigenetic Levels in the Rat Prefrontal Cortex: Modulatory Activity of Lurasidone

Brivio, P., Sbrini, G., Tarantini, L., Parravicini, C., Gruca, P., Łasoń, M., Litwa, E., Favero, C., Riva, M. A., Eberini, I., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126197 · Cited by 31

In vitro modeling of the neurobiological effects of glucocorticoids: A review

Bassil, K. C., Krontira, A. C., Leroy, T., Escoto, A. I. H., Snijders, C., Pernia, C. D., Pasterkamp, R. J., de Nijs, L., van den Hove, D., Kenis, G., et al. (2023) · Neurobiology of Stress · doi:10.1016/j.ynstr.2023.100530 · Cited by 35

Mineralocorticoid receptor associates with pro‐inflammatory bias in the hippocampus of spontaneously hypertensive rats

Brocca, M. E., Pietranera, L., Meyer, M., Lima, A. E., Roig, P., de Kloet, E. R., & Nicola, A. F. D. (2017) · Journal of Neuroendocrinology · doi:10.1111/jne.12489 · Cited by 30

Current and future functional imaging techniques for post-traumatic stress disorder

Prasad, A., Chaichi, A., Kelley, D. P., Francis, J., & Gartia, M. R. (2019) · RSC Advances · doi:10.1039/c9ra03562a · Cited by 32

Do changes in microglial status underlie neurogenesis impairments and depressive-like behaviours induced by psychological stress? A systematic review in animal models

Nieto-Quero, A., Chaves-Peña, P., Santín, L. J., Pérez‐Martín, M., & Pedraza, C. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100356 · Cited by 32

The activity of the glucocorticoid receptor is regulated by SUMO conjugation to FKBP51

Antunica-Noguerol, M., Budziñski, M. L., Druker, J., Gassen, N. C., Sokn, C., Senin, S. A., Aprile-Garcia, F., Holsboer, F., Rein, T., Liberman, A. C., et al. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2016.44 · Cited by 29

Leonurine promotes neurite outgrowth and neurotrophic activity by modulating the GR/SGK1 signaling pathway in cultured PC12 cells

Meng, P., Zhu, Q., Yang, H., Liu, D., Lin, X., Liu, J., Fan, J., Liu, X., Su, W., Liu, L., et al. (2019) · Neuroreport · doi:10.1097/wnr.0000000000001180 · Cited by 31

Prenatal glucocorticoid exposure selectively impairs neuroligin 1-dependent neurogenesis by suppressing astrocytic FGF2–neuronal FGFR1 axis

Choi, G. E., Chae, C. W., Park, M. R., Yoon, J. H., Jung, Y. H., Lee, H. J., & Han, H. J. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04313-2 · Cited by 28

Regulatory mechanism of icariin in cardiovascular and neurological diseases

Wang, Y., Shang, C., Zhang, Y., Xin, L., Jiao, L., Xiang, M., Shen, Z., Chen, C., Ding, F., Lu, Y., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.114156 · Cited by 29

Predicting progression to Alzheimer’s disease with human hippocampal progenitors exposed to serum

Maruszak, A., Silajdžić, E., Lee, H.-A., Murphy, T., Liu, B., Shi, L., de Lucia, C., Douiri, A., Salta, E., Nevado‐Holgado, A. J., et al. (2022) · Brain · doi:10.1093/brain/awac472 · Cited by 32

Mechanisms behind context-dependent role of glucocorticoids in breast cancer progression

Butz, H., & Patócs, A. (2022) · Cancer metastasis reviews · doi:10.1007/s10555-022-10047-1 · Cited by 27

Chronic Corticosterone Administration-Induced Mood Disorders in Laboratory Rodents: Features, Mechanisms, and Research Perspectives

Wang, H., Wang, X., Wang, H., Shao, S.-J., & Zhu, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252011245 · Cited by 28

Transcriptomic analyses and leukocyte telomere length measurement in subjects exposed to severe recent stressful life events

Lopizzo, N., Tosato, S., Begni, V., Tomassi, S., Cattane, N., Barcella, M., Turco, G., Ruggeri, M., Riva, M. A., Pariante, C. M., et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.5 · Cited by 26

Effects of the Ethanol Extract of Dipterocarpus alatus Leaf on the Unpredictable Chronic Mild Stress-Induced Depression in ICR Mice and Its Possible Mechanism of Action

Daodee, S., Monthakantirat, O., Ruengwinitwong, K., Gatenakorn, K., Maneenet, J., Khamphukdee, C., Şekeroğlu, N., Chulikhit, Y., & Kijjoa, A. (2019) · Molecules · doi:10.3390/molecules24183396 · Cited by 26

Acute stress induces severe neural inflammation and overactivation of glucocorticoid signaling in interleukin-18-deficient mice

Yamanishi, K., Doe, N., Mukai, K., Hashimoto, T., Gamachi, N., Hata, M., Watanabe, Y., Yamanishi, C., Yagi, H., Okamura, H., et al. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02175-7 · Cited by 30

Heterogeneity in major depressive disorder: The need for biomarker-based personalized treatments

Suseelan, S., & Pinna, G. (2022) · Advances in clinical chemistry · doi:10.1016/bs.acc.2022.09.001 · Cited by 28

The role of depression and neuroimmune axis in the prognosis of cancer patients.

Aldea, M. D., Craciun, L., Tomuleasa, C., & Crivii, C. B. (2014) · PubMed · Cited by 26

Stress, Depression, Resilience and Ageing: A Role for the LPA-LPA1 Pathway

Moreno‐Fernández, R. D., Tabbai, S., Castilla‐Ortega, E., Pérez‐Martín, M., Estivill‐Torrús, G., Fernando, R. D. F., Santín, L. J., & Pedraza, C. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666170710200352 · Cited by 26

Long-term obesity is associated with depression and neuroinflammation

Lorena, F. B., do Nascimento, B. P. P., Camargo, E. L. R. A., Bernardi, M. M., Fukushima, A. R., Panizza, J. D. N., Nogueira, P. D. B., Brandão, M. E., & Ribeiro, M. O. (2021) · Archives of Endocrinology and Metabolism · doi:10.20945/2359-3997000000400 · Cited by 26

Mechanisms of paeoniaceae action as an antidepressant

Guo, W., Yao, X.-X., Cui, R., Yang, W., & Wang, L. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.934199 · Cited by 27

How can the depressed mind extract and remember predictive relationships of the environment? Evidence from implicit probabilistic sequence learning

Janacsek, K., Borbély-Ipkovich, E., Németh, D., & Gonda, X. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.09.021 · Cited by 24

The role of circulatory systemic environment in predicting interferon-alpha–induced depression: The neurogenic process as a potential mechanism

Borsini, A., Pariante, C. M., Zunszain, P. A., Hepgul, N., Russell, A., Zajkowska, Z., Mondelli, V., & Thuret, S. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.06.018 · Cited by 23

Glucocorticoids Suppress the Protective Effect of Cyclooxygenase-2-Related Signaling on Hippocampal Neurogenesis Under Acute Immune Stress

Ma, Y., Matsuwaki, T., Yamanouchi, K., & Nishihara, M. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9766-9 · Cited by 24

Suppression of Nuclear Factor-κB by Glucocorticoid Receptor Blocks Estrogen-Induced Apoptosis in Estrogen-Deprived Breast Cancer Cells

Fan, P., Siwak, D. R., Abderrahman, B., Agboke, F. A., Yerrum, S., & Jordan, V. C. (2019) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-18-1363 · Cited by 24

Does epigenetic ‘memory’ of early-life stress predispose to chronic pain in later life? A potential role for the stress regulator FKBP5

Géranton, S. M. (2019) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2019.0283 · Cited by 24

Acupuncture inhibits the increase in alpha-Synuclein by modulating SGK1 in an MPTP induced parkinsonism mouse model

Yeo, S., & Lim, S. (2019) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x19500277 · Cited by 23

Identifying causative mechanisms linking early-life stress to psycho-cardio-metabolic multi-morbidity: The EarlyCause project

Mariani, N., Borsini, A., Cecil, C. A. M., Felix, J. F., Sebert, S. P., Cattaneo, A., Walton, E., Milaneschi, Y., Cochrane, G., Amid, C., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0245475 · Cited by 23

Chronic Isolation Stress Affects Central Neuroendocrine Signaling Leading to a Metabolically Active Microenvironment in a Mouse Model of Breast Cancer

Berry, A., Collacchi, B., Capoccia, S., D’Urso, M. T., Cecchetti, S., Raggi, C., Sestili, P., Aricò, E., Pontecorvi, G., Puglisi, R., et al. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.660738 · Cited by 23

Serum- and glucocorticoid-inducible kinases in microglia

Inoue, K., Sakuma, E., Morimoto, H., Asai, H., Koide, Y., Leng, T., Wada, I., Xiong, Z., & Ueki, T. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.07.094 · Cited by 23

Serum- and glucocorticoid-induced kinase 1, a new therapeutic target for autophagy modulation in chronic diseases

Maestro, I., Boya, P., & Martínez, A. (2020) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2020.1730328 · Cited by 22

GSK-3β and ERK1/2 incongruously act in tau hyperphosphorylation in SPS-induced PTSD rats

Wei, Z. C., Mahaman, Y. A. R., Zhu, F., Wu, M., Xia, Y., Zeng, K., Yang, Y., Liu, R., Wang, J., Shu, X., et al. (2019) · Aging · doi:10.18632/aging.102303 · Cited by 22

Sub-chronic stress induces similar behavioral effects in male and female mice despite sex-specific molecular adaptations in the nucleus accumbens

Baugher, B. J., Buckhaults, K., Case, J. M., Sullivan, A., Huq, S. N., & Sachs, B. D. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.113811 · Cited by 22

Chronic exercise prevents repeated restraint stress-provoked enhancement of immobility in forced swimming test in ovariectomized mice

Han, T., Lee, J.-K., & Leem, Y. (2014) · Metabolic Brain Disease · doi:10.1007/s11011-014-9624-2 · Cited by 22

Neuropsin Inactivation Has Protective Effects against Depressive-Like Behaviours and Memory Impairment Induced by Chronic Stress

Chang, S., Bok, P., Sun, C., Edwards, A., & Huang, G. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1006356 · Cited by 21

Supplementation with low molecular weight peptides from fish protein hydrolysate reduces acute mild stress-induced corticosterone secretion and modulates stress responsive gene expression in mice

Dinel, A., Lucas, C., Faouder, J. L., Bouvret, E., Pallet, V., Layé, S., & Joffre, C. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.104292 · Cited by 21

Virus-Host Interactions of Enteroviruses and Parvovirus B19 in Myocarditis

Ho, H. T., Peischard, S., Strutz‐Seebohm, N., & Seebohm, G. (2021) · Cellular Physiology and Biochemistry · doi:10.33594/000000470 · Cited by 20

The Long-Term Effects of Early Life Stress on the Modulation of miR-19 Levels

Mazzelli, M., Maj, C., Mariani, N., Mora, C., Begni, V., Pariante, C. M., Riva, M. A., Cattaneo, A., & Cattane, N. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00389 · Cited by 21

Emerging Role of Serum Glucocorticoid-Regulated Kinase 1 in Pathological Pain

Liu, B., Li, N., He, Z., Zhang, X., & Duan, G. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.683527 · Cited by 20

Expression of glucocorticoid inducible genes is associated with reductions in cornu ammonis and dentate gyrus volumes in patients with major depressive disorder

Frodl, T., Carballedo, A., Frey, E.-M., O'Keane, V., Skokauskas, N., Morris, D., Gill, M., Hughes, M. M., Harkin, A., & Connor, T. (2014) · Development and Psychopathology · doi:10.1017/s0954579414000972 · Cited by 20

Oleanolic acid decreases SGK1 in the hippocampus in corticosterone-induced mice

Dong, S., Wang, S., Zhu, J., Mu, R.-H., Li, C., Geng, D., Liu, Q., & Yi, L. (2019) · Steroids · doi:10.1016/j.steroids.2019.05.011 · Cited by 20

Research Progress on the Antidepressant Effects of Baicalin and Its Aglycone Baicalein: A Systematic Review of the Biological Mechanisms

Wang, C., & Ming-qi, G. (2023) · Neurochemical Research · doi:10.1007/s11064-023-04026-3 · Cited by 21

Antidepressant-like Effect of Oroxylum indicum Seed Extract in Mice Model of Unpredictable Chronic Mild Stress

Chalermwongkul, C., Khamphukdee, C., Maneenet, J., Daodee, S., Monthakantirat, O., Boonyarat, C., Chotritthirong, Y., Awale, S., Kijjoa, A., & Chulikhit, Y. (2023) · Nutrients · doi:10.3390/nu15224742 · Cited by 19

Sex differences in a corticosterone-induced depression model in mice: Behavioral, neurochemical, and molecular insights

Tao, Y., Shen, W., Zhou, H., Li, Z., Pi, T., Wu, H., Shi, H., Huang, F., & Wu, X. (2023) · Brain Research · doi:10.1016/j.brainres.2023.148678 · Cited by 19

Adaptor Protein APPL2 Affects Adult Antidepressant Behaviors and Hippocampal Neurogenesis via Regulating the Sensitivity of Glucocorticoid Receptor

Gao, C., Chen, X., Xu, A., Cheng, K. K. Y., & Shen, J. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0785-y · Cited by 19

Ribosomal dysregulation: A conserved pathophysiological mechanism in human depression and mouse chronic stress

Zhang, X., Eladawi, M. A., Ryan, W. G., Fan, X., Prevoznik, S., Devale, T., Ramnani, B., Malathi, K., Sibille, E. L., McCullumsmith, R. E., et al. (2023) · PNAS Nexus · doi:10.1093/pnasnexus/pgad299 · Cited by 21

Decreased expression of serum- and glucocorticoid-inducible kinase 1 (SGK1) promotes alpha-synuclein increase related with down-regulation of dopaminergic cell in the substantia Nigra of chronic MPTP-induced parkinsonism mice and in SH-SY5Y cells

Yeo, S., Sung, B., Hong, Y.-M., van den Noort, M., Bosch, P., Lee, S.-H., Song, J., Park, S.-K., & Lim, S. (2018) · Gene · doi:10.1016/j.gene.2018.03.086 · Cited by 18

SGK1 suppresses ferroptosis in ovarian cancer via NRF2-dependent and -independent pathways

Sang, X., Han, J., Wang, Z., Cai, W., Liao, X., Kong, Z., Yu, Z., Cheng, H.-L. M., & Liu, P. (2024) · Oncogene · doi:10.1038/s41388-024-03173-3 · Cited by 17

Depression during pregnancy: molecular regulations of mothers’ and children's behaviour

Pariante, C. M. (2014) · Biochemical Society Transactions · doi:10.1042/bst20130246 · Cited by 17

Serum‐ and glucocorticoid‐inducible kinase 1 promotes insulin resistance in adipocytes via degradation of insulin receptor substrate 1

Zhang, M., Chen, H., Liu, M., Zhu, K., Yan, H., Zhu, D., & Li, P. (2021) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3451 · Cited by 16

Serum from Older Adults Increases Apoptosis and Molecular Aging Markers in Human Hippocampal Progenitor Cells

de Lucia, C., Murphy, T., Maruszak, A., Wright, P., Powell, T. R., Hartopp, N., de Jong, S., O'Sullivan, M. J., Breen, G. D., Price, J., et al. (2021) · Aging and Disease · doi:10.14336/ad.2021.0409 · Cited by 16

Anti-stress Properties of Atypical Antipsychotics

Sanson, A., & Riva, M. A. (2020) · Pharmaceuticals · doi:10.3390/ph13100322 · Cited by 17

From placenta to the foetus: a systematic review of in vitro models of stress- and inflammation-induced depression in pregnancy

Kirkpatrick, M., Mandal, G., Elhadidy, I., Mariani, N., Priestley, K., Pariante, C. M., & Borsini, A. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02866-1 · Cited by 20

Influence of pharmacological and epigenetic factors to suppress neurotrophic factors and enhance neural plasticity in stress and mood disorders

Tarai, S., Mukherjee, R., Gupta, S., Rizvanov, A. A., Palotás, A., Pammi, V. S. C., & Bit, A. (2019) · Cognitive Neurodynamics · doi:10.1007/s11571-019-09522-3 · Cited by 16

Steroid hormones and hippocampal neurogenesis in the adult mammalian brain

Hodges, T. E., Puri, T. A., Blankers, S. A., Qiu, W., & Galea, L. A. M. (2022) · Vitamins and hormones · doi:10.1016/bs.vh.2021.11.003 · Cited by 17

Stem Cells in Neuroendocrinology

Pfaff, D., & Christen, Y. (2016) · Research and perspectives in endocrine interactions · doi:10.1007/978-3-319-41603-8 · Cited by 16

Plausible Role of Stem Cell Types for Treating and Understanding the Pathophysiology of Depression

Sachdeva, P., Ji, S., Ghosh, S., Ghosh, S., Raghunath, M., Kim, H., Bhaskar, R., Sinha, J. K., & Han, S. S. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15030814 · Cited by 17

Ketamine Prevents Inflammation-Induced Reduction of Human Hippocampal Neurogenesis via Inhibiting the Production of Neurotoxic Metabolites of the Kynurenine Pathway

Mandal, G., Kirkpatrick, M., Alboni, S., Mariani, N., Pariante, C. M., & Borsini, A. (2024) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyae041 · Cited by 15

The dietary ligands, omega-3 fatty acid endocannabinoids and short-chain fatty acids prevent cytokine-induced reduction of human hippocampal neurogenesis and alter the expression of genes involved in neuroinflammation and neuroplasticity

Mandal, G., Alboni, S., Cattane, N., Marizzoni, M., Saleri, S., Arslanovski, N., Mariani, N., Kirkpatrick, M., Cattaneo, A., Pariante, C. M., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03119-5 · Cited by 15

Effect of acute psychosocial stress on the brain-derived neurotrophic factor in humans – a randomized cross within trial

Hermann, R. M., Schaller, A., Lay, D., Bloch, W., Albus, C., & Petrowski, K. (2020) · Stress · doi:10.1080/10253890.2020.1854218 · Cited by 15

Stress, mental disorder and ketamine as a novel, rapid acting treatment

Dutton, M., Can, A., Lagopoulos, J., & Hermens, D. F. (2022) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2022.09.006 · Cited by 17

O papel do estresse e de acontecimentos cotidianos para o desenvolvimento da depressão na terceira idade

Gameiro, G. R., Minguini, I. P., & Alves, T. C. T. F. (2014) · Revista de Medicina · doi:10.11606/issn.1679-9836.v93i1p31-40 · Cited by 16

Hypothesis: High salt intake as an inflammation amplifier might be involved in the pathogenesis of neuropsychiatric disorders

Abdoli, A. (2017) · Clinical and Experimental Neuroimmunology · doi:10.1111/cen3.12389 · Cited by 16

Upregulation of serum and glucocorticoid-regulated kinase 1 exacerbates brain injury and neurological deficits after cardiac arrest

Lee, R. H.-C., Grames, M. S., Wu, C. Y.-C., Lien, C.-F., Couto e Silva, A., Possoit, H. E., Clemons, G. A., Citadin, C. T., Neumann, J. T., Pastore, D., et al. (2020) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00399.2020 · Cited by 15

Glucocorticoid receptor overexpression in the dorsal Hippocampus attenuates spatial learning and synaptic plasticity deficits after pediatric traumatic brain injury

Lengel, D., Romm, Z. L., Bostwick, A., Huh, J. W., Snyder, N. W., Smith, G. M., & Raghupathi, R. (2022) · Journal of Neurotrauma · doi:10.1089/neu.2022.0012 · Cited by 14

An update on the long-term outcomes of prenatal dexamethasone treatment in congenital adrenal hyperplasia

Westeinde, A. V., Karlsson, L., Messina, V., Wallensteen, L., Brösamle, M., Maso, G. D., Lazzerini, A., Kristensen, J. K., Kwast, D., Tschaidse, L., et al. (2023) · Endocrine Connections · doi:10.1530/ec-22-0400 · Cited by 14

Chronic Restraint Stress Decreases the Excitability of Hypothalamic POMC Neuron and Increases Food Intake

Ha, G. E., & Cheong, E. (2021) · Experimental Neurobiology · doi:10.5607/en21037 · Cited by 13

Dietary emulsifier consumption alters gene expression in the amygdala and paraventricular nucleus of the hypothalamus in mice

Arnold, A. R., Chassaing, B., Pearce, B. D., & Huhman, K. L. (2022) · Scientific Reports · doi:10.1038/s41598-022-13021-7 · Cited by 14

Patients with hypercortisolemic Cushing disease possess a distinct class of hematopoietic progenitor cells leading to erythrocytosis

Varricchio, L., Geer, E. B., Martelli, F., Mazzarini, M., Funnell, A. P. W., Bieker, J. J., Papayannopoulou, T., & Migliaccio, A. R. (2022) · Haematologica · doi:10.3324/haematol.2021.280542 · Cited by 14

An expandable donor-free supply of functional hepatocytes for toxicology

Probert, P. M. E., Meyer, S. K., Alsaeedi, F. A., Axon, A. A., Fairhall, E. A., Wallace, K., Charles, M. A., Oakley, F., Jowsey, P. A., Blain, P. G., et al. (2015) · Toxicology Research · doi:10.1039/c4tx00214h · Cited by 14

Serum/glucocorticoid regulated kinase 1 (SGK1) in neurological disorders: pain or gain

Howard, P. G., Zou, P., Zhang, Y., Huang, F., Tesic, V., Wu, C. Y.-C., & Lee, R. H.-C. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.114973 · Cited by 13

Decoding the transcriptional programs activated by psychotropic drugs in the brain

Zygmunt, M., Piechota, M., Parkitna, J. M. R., & Korostyński, M. (2018) · Genes Brain & Behavior · doi:10.1111/gbb.12511 · Cited by 13

Activation of the anti‐inflammatory reflex blocks lipopolysaccharide‐induced decrease in synaptic inhibition in the temporal cortex of the rat

García‐Oscos, F., Peña, D. F., Housini, M., Cheng, D., Lopez, D. A., Cuevas‐Olguin, R., Saderi, N., Delgado, R. S., Galindo‐Charles, L., Salgado, H., et al. (2015) · Journal of Neuroscience Research · doi:10.1002/jnr.23550 · Cited by 12

Memory-related neurophysiological mechanisms in the hippocampus underlying stress susceptibility

Kuga, N., & Sasaki, T. (2022) · Neuroscience Research · doi:10.1016/j.neures.2022.07.010 · Cited by 12

Overnight Corticosterone and Gene Expression in Mouse Hippocampus: Time Course during Resting Period

Jaszczyk, A., Stankiewicz, A. M., Gościk, J., Majewska, A., Jezierski, T., & Juszczak, G. R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032828 · Cited by 13

Molecular Mechanisms of Depression

Varidaki, A., Mohammad, H., & Coffey, E. T. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802456-0.00005-4 · Cited by 13

Cytoplasmic translocation of MTA1 coregulator promotes de-repression of SGK1 transcription in hypoxic cancer cells

Marzook, H., Sankaran, D., George, B., Reshmi, G., Santhoshkumar, T. R., Kumar, R., & Pillai, M. R. (2017) · Oncogene · doi:10.1038/onc.2017.19 · Cited by 12

T131. Epigenetic Mechanisms Underlying the Stress-Induced Activation of SGK1

Cattane, N., Mora, C., Riva, M. A., Pariante, C. M., & Cattaneo, A. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.03.454

Data Point to Enzyme’s Role in Stress, Depression

Yan, J. (2013) · Psychiatric News · doi:10.1176/appi.pn.2013.6b5

Glucocorticoid-Related Molecular Signaling Pathways Regulating Hippocampal Neurogenesis

Anacker, C., Cattaneo, A., Luoni, A., Musaelyan, K., Zunszain, P. A., Milanesi, E., Rybka, J., Berry, A., Cirulli, F., Thuret, S., et al. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.253 · Cited by 331

Hippocampal SGK1 promotes vulnerability to depression: the role of early life adversity, stress, and genetic risk

Millette, A., van Dijk, M. T., Pokhvisneva, I., Li, Y., Thompson, R., Patel, S. H., Bagot, R. C., Náray‐Fejes‐Tóth, A., Fejes‐Tóth, G., Silveira, P. P., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03269-6 · Cited by 9

Glucocorticoid Receptor Down-Regulation Affects Neural Stem Cell Proliferation and Hippocampal Neurogenesis

Kim, S., Yang, S., Kim, J., Chung, K. W., Jung, Y., Chung, H. Y., & Lee, J. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03785-y · Cited by 16