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Optimizing water permeability through the hourglass shape of aquaporins
Open accessAbstract
Significance: Aquaporin channels are able to selectively conduct water across cell membranes, with remarkable efficiency. Although molecular details are crucial to the pore performance, permeability is also strongly limited by viscous dissipation at the entrances. Could the hourglass shape of aquaporins optimize such entrance effects? We show that conical entrances with suitable opening angle can indeed provide a large increase of the channel permeability. Strikingly, the optimal opening angles compare well with the angles measured in a large variety of aquaporins, suggesting that their hourglass shape could be the result of a natural selection process toward optimal permeability. This work also provides guidelines to optimize the performances of artificial nanopores, with applications in desalination, ultrafiltration, or energy conversion.
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Cites
Climatic Impact of Tropical Lowland Deforestation on Nearby Montane Cloud Forests
Lawton, R. O., Nair, U. S., Pielke, R. A., & Welch, R. M. (2001) · Science · doi:10.1126/science.1062459 · Cited by 1,169
Structural basis of water-specific transport through the AQP1 water channel
Sui, H., Han, B.-G., Lee, J. K., Walian, P., & Jap, B. K. (2001) · Nature · doi:10.1038/414872a · Cited by 1,166
Cited by
Critical Knowledge Gaps in Mass Transport through Single-Digit Nanopores: A Review and Perspective
Faucher, S., Aluru, N., Bazant, M. Z., Blankschtein, D., Brozena, A. H., Cumings, J., Pedro de Souza, J., Elimelech, M., Epsztein, R., Fourkas, J. T., et al. (2019) · The Journal of Physical Chemistry C · doi:10.1021/acs.jpcc.9b02178 · Cited by 365
Lipid osmosis, membrane tension, and other mechanochemical driving forces of lipid flow
Zhang, Y., & Lin, C. (2024) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2024.102377 · Cited by 14
Metadata
- Authors
- Gravelle, S., Joly, L., Detcheverry, F., Ybert, C., Cottin-Bizonne, C., & Bocquet, L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2013-09-25
- Volume
- 110
- Issue
- 41
- Pages
- 16367-16372
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1994525470
- Cited by
- 252
- References
- 2
- FWCI
- 9.39
- Type
- journal article
- Language
- en
- Open access
- green
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- Gravelle, S., Joly, L., Detcheverry, F., Ybert, C., Cottin-Bizonne, C., & Bocquet, L. (2013). Optimizing water permeability through the hourglass shape of aquaporins. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1306447110
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