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Cited by 313

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques

Open access
de Wit, Emmie, Rasmussen, Angela L., Falzarano, Darryl, Bushmaker, Trenton, Feldmann, Friederike, Brining, Douglas L., Fischer, Elizabeth R., Martellaro, Cynthia, Okumura, Atsushi, Chang, Jean, Scott, Dana, Benecke, Arndt G., Katze, Michael G., Feldmann, Heinz, Munster, Vincent J.·2013·Proceedings of the National Academy of Sciences

Abstract

Significance: The Middle East respiratory syndrome coronavirus (MERS-CoV) is the latest emerged coronavirus causing severe respiratory disease with a high case fatality rate in humans. To better understand the disease caused by MERS-CoV, we developed a rhesus macaque model. Infection of rhesus macaques with MERS-CoV resulted in the rapid development of a transient pneumonia, with MERS-CoV replication largely restricted to the lower respiratory tract. This affinity of MERS-CoV for the lungs partly explains the severity of the disease observed in humans. The MERS-CoV rhesus macaque model will be instrumental in developing and testing vaccine and treatment options for an emerging viral pathogen with pandemic potential.

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Metadata

Authors
de Wit, E., Rasmussen, A. L., Falzarano, D., Bushmaker, T., Feldmann, F., Brining, D. L., Fischer, E. R., Martellaro, C., Okumura, A., Chang, J., Scott, D., Benecke, A. G., Katze, M. G., Feldmann, H., & Munster, V. J.
Venue
Proceedings of the National Academy of Sciences
Published
2013-09-23
Volume
110
Issue
41
Pages
16598-16603
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2016428878
Cited by
313
References
3
FWCI
22.66
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques. https://app.cochat.ai/papers/10.1073/pnas.1310744110
The paper
de Wit, E., Rasmussen, A. L., Falzarano, D., Bushmaker, T., Feldmann, F., Brining, D. L., Fischer, E. R., Martellaro, C., Okumura, A., Chang, J., Scott, D., Benecke, A. G., Katze, M. G., Feldmann, H., & Munster, V. J. (2013). Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1310744110

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.