The DOI matches its Crossref record.
Diagnosis of tumors during tissue-conserving surgery with integrated autofluorescence and Raman scattering microscopy
Open accessAbstract
Significance: Histopathology is the standard method for diagnosis of cancer. However, this method requires time-consuming procedures for sectioning and staining of tissues, making histopathology impractical for use during surgery for most cancer types. We report a unique method based on two optical spectroscopy techniques—autofluorescence imaging and Raman scattering—that can accurately measure molecular differences between tumor cells and healthy tissue and allows diagnosis of tumors faster than histopathology, without requiring tissue sectioning or staining. Our study demonstrates the potential of this technique for diagnosis of tissues during cancer surgery, providing a quick and objective way to determine whether the tissue layers removed by the surgeon are clear of tumor.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Kong, K., Kendall, C., Stone, N., & Notingher, I. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.03.009 · Cited by 653
Self-citationRaman spectroscopy: techniques and applications in the life sciences
Shipp, D. W., Sinjab, F., & Notingher, I. (2017) · Advances in Optics and Photonics · doi:10.1364/aop.9.000315 · Cited by 396
Self-citationAdvantages and limitations of Raman spectroscopy for molecular diagnostics: an update
Eberhardt, K., Stiebing, C., Matthäus, C., Schmitt, M., & Popp, J. (2015) · Expert Review of Molecular Diagnostics · doi:10.1586/14737159.2015.1036744 · Cited by 282
Wang, Y. “., Reder, N. P., Kang, S., Glaser, A. K., Yang, Q., Wall, M. A., Javid, S. H., Dintzis, S. M., & Liu, J. T. C. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-0709 · Cited by 104
Raman Spectroscopy and Its Modifications Applied to Biological and Medical Research
Allakhverdiev, E. S., Khabatova, V. V., Kossalbayev, B. D., Zadneprovskaya, E. V., Rodnenkov, O. V., Martynyuk, T. V., Maksimov, G. V., Alwasel, S., Tomo, T., & Allakhverdiev, S. I. (2022) · Cells · doi:10.3390/cells11030386 · Cited by 88
Metadata
- Authors
- Kong, K., Rowlands, C. J., Varma, S., Perkins, W., Leach, I. H., Koloydenko, A. A., Williams, H. C., & Notingher, I.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2013-09-03
- Volume
- 110
- Issue
- 38
- Pages
- 15189-15194
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2163932563
- Cited by
- 234
- References
- 0
- FWCI
- 11.58
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Diagnosis of tumors during tissue-conserving surgery with integrated autofluorescence and Raman scattering microscopy. https://app.cochat.ai/papers/10.1073/pnas.1311289110
- The paper
- Kong, K., Rowlands, C. J., Varma, S., Perkins, W., Leach, I. H., Koloydenko, A. A., Williams, H. C., & Notingher, I. (2013). Diagnosis of tumors during tissue-conserving surgery with integrated autofluorescence and Raman scattering microscopy. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1311289110
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
