The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Deciphering the design of the tropomyosin molecule
Open accessAbstract
The crystal structure at 2.0-Å resolution of an 81-residue N-terminal fragment of muscle α-tropomyosin reveals a parallel two-stranded α-helical coiled-coil structure with a remarkable core. The high alanine content of the molecule is clustered into short regions where the local 2-fold symmetry is broken by a small (≈1.2-Å) axial staggering of the helices. The joining of these regions with neighboring segments, where the helices are in axial register, gives rise to specific bends in the molecular axis. We observe such bends to be widely distributed in two-stranded α-helical coiled-coil proteins. This asymmetric design in a dimer of identical (or highly similar) sequences allows the tropomyosin molecule to adopt multiple bent conformations. The seven alanine clusters in the core of the complete molecule (which spans seven monomers of the actin helix) promote the semiflexible winding of the tropomyosin filament necessary for its regulatory role in muscle contraction.
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Cites
Principles that Govern the Folding of Protein Chains
Anfinsen, C. B. (1973) · Science · doi:10.1126/science.181.4096.223 · Cited by 7,096
The packing of α-helices: simple coiled-coils
Crick, F. H. C. (1953) · Acta Crystallographica · doi:10.1107/s0365110x53001964 · Cited by 1,578
A Switch Between Two-, Three-, and Four-stranded Coiled Coils in GCN4 Leucine Zipper Mutants
Harbury, P. B., Zhang, T., Kim, P. S., & Alber, T. (1993) · Science · doi:10.1126/science.8248779 · Cited by 1,490
Predicting oligomerization states of coiled coils
Woolfson, D. N., & Alber, T. (1995) · Protein Science · doi:10.1002/pro.5560040818 · Cited by 214
Cited by
The Structure of α-Helical Coiled Coils
Lupas, A. N., & Gruber, M. (2005) · Advances in Protein Chemistry · doi:10.1016/s0065-3233(05)70003-6 · Cited by 667
Tropomyosin-Based Regulation of the Actin Cytoskeleton in Time and Space
Gunning, P., O’neill, G., & Hardeman, E. (2008) · Physiological Reviews · doi:10.1152/physrev.00001.2007 · Cited by 478
Molecular properties of food allergens
Breiteneder, H., & Mills, E. N. C. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2004.10.022 · Cited by 359
Parry, D. A. D., Fraser, R. D. B., & Squire, J. M. (2008) · Journal of Structural Biology · doi:10.1016/j.jsb.2008.01.016 · Cited by 264
Molecular and functional characterization of a novel cardiac-specific human tropomyosin isoform
Rajan, S., Jagatheesan, G., Karam, C. N., Alves, M. L., Bodi, I., Schwartz, A., Bulcao, C. F., D'Souza, K. M., Akhter, S. A., Boivin, G. P., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.889725 · Cited by 92
Metadata
- Authors
- Brown, J. H., Kim, K.-H., Jun, G., Greenfield, N. J., Dominguez, R., Volkmann, N., Hitchcock-DeGregori, S. E., & Cohen, C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2001-07-03
- Volume
- 98
- Issue
- 15
- Pages
- 8496-8501
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2038253226
- Cited by
- 244
- References
- 4
- FWCI
- 4.89
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Brown, J. H., Kim, K.-H., Jun, G., Greenfield, N. J., Dominguez, R., Volkmann, N., Hitchcock-DeGregori, S. E., & Cohen, C. (2001). Deciphering the design of the tropomyosin molecule. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.131219198
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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