The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
The king cobra genome reveals dynamic gene evolution and adaptation in the snake venom system
Open accessAbstract
Significance: Snake venoms are toxic protein cocktails used for prey capture. To investigate the evolution of these complex biological weapon systems, we sequenced the genome of a venomous snake, the king cobra, and assessed the composition of venom gland expressed genes, small RNAs, and secreted venom proteins. We show that regulatory components of the venom secretory system may have evolved from a pancreatic origin and that venom toxin genes were co-opted by distinct genomic mechanisms. After co-option, toxin genes important for prey capture have massively expanded by gene duplication and evolved under positive selection, resulting in protein neofunctionalization. This diverse and dramatic venom-related genomic response seemingly occurs in response to a coevolutionary arms race between venomous snakes and their prey.
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Citations
Cites
Ultrafast and memory-efficient alignment of short DNA sequences to the human genome.
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Stanke, M., Schöffmann, O., Morgenstern, B., & Waack, S. (2006) · BMC Bioinformatics · doi:10.1186/1471-2105-7-62 · Cited by 1,304
The sequence and de novo assembly of the giant panda genome
Li, R., Fan, W., Tian, G., Zhu, H., He, L., Cai, J., Huang, Q., Cai, Q., Li, B., Bai, Y., et al. (2010) · Nature · doi:10.1038/nature08696 · Cited by 1,180
Genome analysis of the platypus reveals unique signatures of evolution
paper, A. L. O. A. A. T. A. A. A. T. E. O. T. (2008) · Nature · doi:10.1038/nature06936 · Cited by 719 · cited 1×
“In contrast with the only other venomous vertebrate genome sequenced to date [the platypus (36, 37)], gene duplication is apparently of fundamental importance in the adaptive evolution of the king cobra venom system.”
ResultFry, B. G. (2005) · Genome Research · doi:10.1101/gr.3228405 · Cited by 486
MicroRNA Expression Is Required for Pancreatic Islet Cell Genesis in the Mouse
Lynn, F. C., Skewes-Cox, P., Kosaka, Y., McManus, M. T., Harfe, B. D., & German, M. S. (2007) · Diabetes · doi:10.2337/db07-0175 · Cited by 351
Cited by
Causes and Consequences of Snake Venom Variation
Casewell, N. R., Jackson, T. N. W., Laustsen, A. H., & Sunagar, K. (2020) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2020.05.006 · Cited by 396
Self-citationThe Genome 10K Project: A Way Forward
Koepfli, K.-P., Paten, B., Scientists, T. G. 1. C. O., & O’Brien, S. J. (2015) · Annual Review of Animal Biosciences · doi:10.1146/annurev-animal-090414-014900 · Cited by 311
Evolution and Diversity of Transposable Elements in Vertebrate Genomes
Sotero-Caio, C. G., Platt, R. N., Suh, A., & Ray, D. A. (2017) · Genome Biology and Evolution · doi:10.1093/gbe/evw264 · Cited by 283
Melani, R. D., Skinner, O. S., Fornelli, L., Domont, G. B., Compton, P. D., & Kelleher, N. L. (2016) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m115.056523 · Cited by 85
Adams, R. H., Blackmon, H., Reyes-Velasco, J., Schield, D. R., Card, D. C., Andrew, A. L., Waynewood, N., & Castoe, T. A. (2016) · Genome · doi:10.1139/gen-2015-0124 · Cited by 50
Self-citationRoscito, J. G., Sameith, K., Kirilenko, B. M., Hecker, N., Winkler, S., Dahl, A., Rodrigues, M. T., & Hiller, M. (2022) · Cell Reports · doi:10.1016/j.celrep.2021.110280 · Cited by 44
Banerjee, S., Bhandary, P., Woodhouse, M., Sen, T. Z., Wise, R. P., & Andorf, C. M. (2021) · BMC Bioinformatics · doi:10.1186/s12859-021-04120-9 · Cited by 35
Choudhury, M., & Das, M. (2025) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.70144 · Cited by 5
Metadata
- Authors
- Vonk, F. J., Casewell, N. R., Henkel, C. V., Heimberg, A. M., Jansen, H. J., McCleary, R. J. R., Kerkkamp, H. M. E., Vos, R. A., Guerreiro, I., Calvete, J. J., Wüster, W., Woods, A. E., Logan, J. M., Harrison, R. A., Castoe, T. A., de Koning, A. P. J., Pollock, D. D., Yandell, M., Calderon, D., Renjifo, C., Currier, R. B., Salgado, D., Pla, D., Sanz, L., Hyder, A. S., Ribeiro, J. M. C., Arntzen, J. W., van den Thillart, G. E. E. J. M., Boetzer, M., Pirovano, W., Dirks, R. P., Spaink, H. P., Duboule, D., McGlinn, E., Kini, R. M., & Richardson, M. K.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2013-12-02
- Volume
- 110
- Issue
- 51
- Pages
- 20651-20656
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2150146437
- Cited by
- 474
- References
- 7
- FWCI
- 32.98
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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