The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
A set of genes critical to development is epigenetically poised in mouse germ cells from fetal stages through completion of meiosis
Open accessAbstract
Significance: Germ cells, meaning the mature sperm and egg and their developmental precursors, carry the DNA that is passed from one generation to the next. Although the sperm and egg are highly specialized, differentiated cells, they meet at fertilization to produce a totipotent zygote, a cell that can generate any other cell type. We report the finding that a set of developmentally important genes is kept in a “poised” state in the germ cells: although these genes are never expressed in the germ cells themselves, they maintain a chromatin state usually associated with the potential for rapid gene activation. We propose that maintenance of this poised state in the germ cells contributes to the generation of totipotency in the fertilized zygote.
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Cites
A bivalent chromatin structure marks key developmental genes in embryonic stem cells
Bernstein, B. E., Mikkelsen, T. S., Xie, X., Kamal, M., Huebert, D. J., Cuff, J., Fry, B., Meissner, A., Wernig, M., Plath, K., et al. (2006) · Cell · doi:10.1016/j.cell.2006.02.041 · Cited by 5,361
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
Mikkelsen, T. S., Ku, M., Jaffe, D. B., Issac, B., Lieberman, E., Giannoukos, G., Alvarez, P., Brockman, W., Kim, T.-K., Koche, R. P., et al. (2007) · Nature · doi:10.1038/nature06008 · Cited by 4,129
Genetic recombination is directed away from functional genomic elements in mice
Brick, K., Smagulova, F., Khil, P., Camerini-Otero, R. D., & Petukhova, G. V. (2012) · Nature · doi:10.1038/nature11089 · Cited by 414
Retinoids regulate stem cell differentiation
Gudas, L. J., & Wagner, J. A. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22417 · Cited by 395
Cited by
A Comprehensive Roadmap of Murine Spermatogenesis Defined by Single-Cell RNA-Seq
Green, C. D., Ma, Q., Manske, G. L., Shami, A. N., Zheng, X., Marini, S., Moritz, L., Sultan, C., Gurczynski, S. J., Moore, B. B., et al. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.07.025 · Cited by 521
Chromatin and Transcription Transitions of Mammalian Adult Germline Stem Cells and Spermatogenesis
Hammoud, S. S., Low, D. H. P., Yi, C., Carrell, D. T., Guccione, E., & Cairns, B. R. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.04.006 · Cited by 346
Epigenetics in male reproduction: effect of paternal diet on sperm quality and offspring health
Schagdarsurengin, U., & Steger, K. (2016) · Nature Reviews Urology · doi:10.1038/nrurol.2016.157 · Cited by 222
In vivo targeting of de novo DNA methylation by histone modifications in yeast and mouse
Morselli, M., Pastor, W. A., Montanini, B., Nee, K., Ferrari, R., Fu, K., Bonora, G., Rubbi, L., Clark, A. T., Ottonello, S., et al. (2015) · eLife · doi:10.7554/elife.06205 · Cited by 167
“To test this hypothesis, we analyzed published H3K4me3 ChIP-seq data (Lesch et al., 2013) and performed H3K36me3 ChIP-seq on sorted germ cells of pooled E13.”
MethodH3K4me1 Distribution Predicts Transcription State and Poising at Promoters
Bae, S., & Lesch, B. J. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00289 · Cited by 120
Self-citation
Metadata
- Authors
- Lesch, B. J., Dokshin, G. A., Young, R. A., McCarrey, J. R., & Page, D. C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2013-09-16
- Volume
- 110
- Issue
- 40
- Pages
- 16061-16066
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2129487614
- Cited by
- 160
- References
- 4
- FWCI
- 6.32
- Type
- journal article
- Language
- en
- Open access
- green
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- Lesch, B. J., Dokshin, G. A., Young, R. A., McCarrey, J. R., & Page, D. C. (2013). A set of genes critical to development is epigenetically poised in mouse germ cells from fetal stages through completion of meiosis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1315204110
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