The DOI matches its Crossref record.
A quorum-sensing inhibitor blocks Pseudomonas aeruginosa virulence and biofilm formation
Open accessAbstract
Significance: In this study, we prepare synthetic molecules and analyze them for inhibition of the Pseudomonas quorum-sensing receptors LasR and RhlR. Our most effective compound, meta-bromo-thiolactone, not only prevents virulence factor expression and biofilm formation but also protects Caenorhabditis elegans and human A549 lung epithelial cells from quorum-sensing–mediated killing by Pseudomonas aeruginosa . This anti–quorum-sensing molecule is capable of influencing P. aeruginosa virulence in tissue culture and animal models. Our findings demonstrate the potential for small-molecule modulators of quorum sensing as therapeutics.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Quorum sensing signal-response systems in Gram-negative bacteria
Papenfort, K., & Bassler, B. L. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.89 · Cited by 2,256
Self-citationStrategies for combating bacterial biofilm infections
Wu, H., Moser, C., Wang, H.-Z., Høiby, N., & Song, Z.-J. (2015) · International Journal of Oral Science · doi:10.1038/ijos.2014.65 · Cited by 925
Targeting virulence: can we make evolution-proof drugs?
Allen, R. C., Popat, R., Diggle, S. P., & Brown, S. P. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3232 · Cited by 532
Bodelón, G., Montes-García, V., López-Puente, V., Hill, E. H., Hamon, C., Sanz-Ortiz, M. N., Rodal-Cedeira, S., Costas, C., Celiksoy, S., Pérez-Juste, I., et al. (2016) · Nature Materials · doi:10.1038/nmat4720 · Cited by 359
Paczkowski, J. E., Mukherjee, S., McCready, A. R., Cong, J.-P., Aquino, C. J., Kim, H., Henke, B. R., Smith, C. D., & Bassler, B. L. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.770552 · Cited by 319
Self-citation
Metadata
- Authors
- O’Loughlin, C. T., Miller, L. C., Siryaporn, A., Drescher, K., Semmelhack, M. F., & Bassler, B. L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2013-10-18
- Volume
- 110
- Issue
- 44
- Pages
- 17981-17986
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1964466122
- Cited by
- 744
- References
- 0
- FWCI
- 19.37
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: A quorum-sensing inhibitor blocks Pseudomonas aeruginosa virulence and biofilm formation. https://app.cochat.ai/papers/10.1073/pnas.1316981110
- The paper
- O’Loughlin, C. T., Miller, L. C., Siryaporn, A., Drescher, K., Semmelhack, M. F., & Bassler, B. L. (2013). A quorum-sensing inhibitor blocks Pseudomonas aeruginosa virulence and biofilm formation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1316981110
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
