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Cyclic diguanosine monophosphate represses bacterial flagella synthesis by interacting with the Walker A motif of the enhancer-binding protein FleQ
Open accessAbstract
Significance: Many bacteria respond to environmental cues by producing cyclic diguanosine monophosphate (c-di-GMP), which binds to proteins to modulate transitions between sessile and motile lifestyles important for chronic and acute infections, respectively. The breadth of protein targets and mechanisms of action of c-di-GMP remain unknown. In the opportunistic pathogen Pseudomonas aeruginosa , c-di-GMP binds to FleQ, a transcription factor that is the master regulator of flagella synthesis and a member of the large family of AAA+ ATPase proteins. We found that c-di-GMP competitively inhibits FleQ ATPase activity and interacts with the ATP-binding site on FleQ. We suggest that AAA+ ATPases from other bacteria may respond to c-di-GMP, and that interference with ATPase activity is one mechanism of c-di-GMP action.
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Cited by
Cyclic di-GMP: second messenger extraordinaire
Jenal, U., Reinders, A., & Lori, C. (2017) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.190 · Cited by 1,039
Valentini, M., & Filloux, A. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.r115.711507 · Cited by 668
Genetic control of bacterial biofilms
Wolska, K. I., Grudniak, A. M., Rudnicka, Z., & Markowska, K. (2016) · Journal of Applied Genetics · doi:10.1007/s13353-015-0309-2 · Cited by 154
Dubey, B. N., Shyp, V., Fucile, G., Sondermann, H., Jenal, U., & Schirmer, T. (2023) · Scientific Reports · doi:10.1038/s41598-023-29110-0 · Cited by 2
Metadata
- Authors
- Baraquet, C., & Harwood, C. S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2013-10-28
- Volume
- 110
- Issue
- 46
- Pages
- 18478-18483
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2135696727
- Cited by
- 200
- References
- 0
- FWCI
- 6.99
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Cyclic diguanosine monophosphate represses bacterial flagella synthesis by interacting with the Walker A motif of the enhancer-binding protein FleQ. https://app.cochat.ai/papers/10.1073/pnas.1318972110
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- Baraquet, C., & Harwood, C. S. (2013). Cyclic diguanosine monophosphate represses bacterial flagella synthesis by interacting with the Walker A motif of the enhancer-binding protein FleQ. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1318972110
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