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Cited by 468

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Derivation of naïve human embryonic stem cells

Open access
Ware, Carol B., Nelson, Angelique M., Mecham, Brigham, Hesson, Jennifer, Zhou, Wenyu, Jonlin, Erica C., Jimenez-Caliani, Antonio J., Deng, Xinxian, Cavanaugh, Christopher, Cook, Savannah, Tesar, Paul J., Okada, Jeffrey, Margaretha, Lilyana, Sperber, Henrik, Choi, Michael, Blau, C. Anthony, Treuting, Piper M., Hawkins, R. David, Cirulli, Vincenzo, Ruohola-Baker, Hannele·2014·Proceedings of the National Academy of Sciences

Abstract

Significance: We report on generation of nontransgenic, naïve human pluripotent cells that represent the developmentally earliest state described for human established cells. Existing human ES cell lines in the later primed state can be toggled in reverse to naïve by exposure to histone deacetylase inhibitors prior to naïve culture. A new line was established directly from an eight-cell embryo under naïve culture conditions. We describe the naïve state in humans and show that naïve human ES cells have expanded endoderm developmental capacity.

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Metadata

Authors
Ware, C. B., Nelson, A. M., Mecham, B., Hesson, J., Zhou, W., Jonlin, E. C., Jimenez-Caliani, A. J., Deng, X., Cavanaugh, C., Cook, S., Tesar, P. J., Okada, J., Margaretha, L., Sperber, H., Choi, M., Blau, C. A., Treuting, P. M., Hawkins, R. D., Cirulli, V., & Ruohola-Baker, H.
Venue
Proceedings of the National Academy of Sciences
Published
2014-03-12
Volume
111
Issue
12
Pages
4484-4489
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W1985439298
Cited by
468
References
1
FWCI
24.94
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Derivation of naïve human embryonic stem cells. https://app.cochat.ai/papers/10.1073/pnas.1319738111
The paper
Ware, C. B., Nelson, A. M., Mecham, B., Hesson, J., Zhou, W., Jonlin, E. C., Jimenez-Caliani, A. J., Deng, X., Cavanaugh, C., Cook, S., Tesar, P. J., Okada, J., Margaretha, L., Sperber, H., Choi, M., Blau, C. A., Treuting, P. M., Hawkins, R. D., Cirulli, V., & Ruohola-Baker, H. (2014). Derivation of naïve human embryonic stem cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1319738111

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.