The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
O-GlcNAcylation regulates EZH2 protein stability and function
Open accessAbstract
Significance: The present study identifies a cross-talk of two important posttranslational modifications, revealing that enhancer of zeste homolog 2 (EZH2) O-GlcNAcylation (GlcNac, N -acetylglucosamine) at serine 75 is required for EZH2 protein stability and therefore facilitates the histone H3 trimethylation at K27 to form H3K27me3. The finding is significant because both O-linked GlcNAc transferase-mediated O-GlcNAcylation and EZH2-mediated H3K27me3 formation play a pivotal role in development, and their up-regulation is believed to participate in tumor malignancy. The identification of O-linked GlcNAc transferase association with the polycomb repressive complex 2 (PRC2) further provides a new approach to regulate PRC2 function.
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Cites
Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing
Cao, R., Wang, L., Wang, H., Xia, L., Erdjument-Bromage, H., Tempst, P., Jones, R. S., & Zhang, Y. (2002) · Science · doi:10.1126/science.1076997 · Cited by 3,775
Kuzmichev, A., Nishioka, K., Erdjument-Bromage, H., Tempst, P., & Reinberg, D. (2002) · Genes & Development · doi:10.1101/gad.1035902 · Cited by 1,596
EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer.
Bracken, A. P., Pasini, D., Capra, M., Prosperini, E., Colli, E., & Helin, K. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg542 · Cited by 1,196
A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells
Knutson, S. K., Wigle, T. J., Warholic, N. M., Sneeringer, C. J., Allain, C. J., Klaus, C. R., Sacks, J. D., Raimondi, A., Majer, C. R., Song, J., et al. (2012) · Nature Chemical Biology · doi:10.1038/nchembio.1084 · Cited by 776
linking metabolism to epigenetics through O-GlcNAcylation
Hanover, J. A., Krause, M. W., & Love, D. C. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3334 · Cited by 414
Essential Role of the Glycosyltransferase Sxc/Ogt in Polycomb Repression
Gambetta, M. C., Oktaba, K., & Müller, J. (2009) · Science · doi:10.1126/science.1169727 · Cited by 315
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Regulation and Role of EZH2 in Cancer
Yamaguchi, H., & Hung, M.-C. (2014) · Cancer Research and Treatment · doi:10.4143/crt.2014.46.3.209 · Cited by 287
The omniscient placenta: Metabolic and epigenetic regulation of fetal programming
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Parental Advisory: Maternal and Paternal Stress Can Impact Offspring Neurodevelopment
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Metadata
- Authors
- Chu, C.-S., Lo, P.-W., Yeh, Y.-H., Hsu, P.-H., Peng, S.-H., Teng, Y.-C., Kang, M.-L., Wong, C.-H., & Juan, L.-J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2014-01-13
- Volume
- 111
- Issue
- 4
- Pages
- 1355-1360
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2050575492
- Cited by
- 231
- References
- 6
- FWCI
- 8.03
- Type
- journal article
- Language
- en
- Open access
- green
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- Chu, C.-S., Lo, P.-W., Yeh, Y.-H., Hsu, P.-H., Peng, S.-H., Teng, Y.-C., Kang, M.-L., Wong, C.-H., & Juan, L.-J. (2014). O-GlcNAcylation regulates EZH2 protein stability and function. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1323226111
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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