Gnotobiotics
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Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
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The gut microbiota is associated with production of tryptamine from tryptophan, and at least 10% of the human population have the necessary gut microbiota decarboxylases for this reaction.
“In addition to bacterial-derived indole and its byproducts, the gut microbiota is also associated with the production of tryptamine from tryptophan, a monoamine similar to 5-HT, and at least 10% of the human population have the necessary gut microbiota decarboxylases for this reaction (Williams, 2014).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Williams, 2014
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Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286 · see citing works
Serotonin, tryptophan metabolism and the brain-gut-microbiome axis
O’Mahony, S. M., Clarke, G., Borre, Y. E., Dinan, T. G., & Cryan, J. F. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.07.027 · Cited by 2,012 · see citing works
Luczynski, P., McVey Neufeld, K.-A., Oriach, C. S., Clarke, G., Dinan, T. G., & Cryan, J. F. (2016) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyw020 · Cited by 632 · see citing works
Kers, J. G., & Saccenti, E. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.796025 · Cited by 359 · see citing works
Gut reactions: Breaking down xenobiotic–microbiome interactions
Clarke, G., Sandhu, K. V., Griffin, B. T., Dinan, T. G., Cryan, J. F., & Hyland, N. P. (2019) · Pharmacological Reviews · doi:10.1124/pr.118.015768 · Cited by 319 · see citing works
Hoban, A. E., Moloney, R. D., Golubeva, A. V., McVey Neufeld, K. A., O’Sullivan, O., Patterson, E., Stanton, C., Dinan, T. G., Clarke, G., & Cryan, J. F. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.10.003 · Cited by 270 · see citing works
Early-life adversity and brain development: Is the microbiome a missing piece of the puzzle?
O’Mahony, S. M., Clarke, G., Dinan, T. G., & Cryan, J. F. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2015.09.068 · Cited by 203 · see citing works
Links between the microbiome and bone
Hernandez, C. J., Guss, J. D., Luna, M., & Goldring, S. R. (2016) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2887 · Cited by 200 · see citing works
- Authors
- Williams, S. C. P.
- Corresponding author
- Williams, Sarah C. P.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2014-02-04
- Volume
- 111
- Issue
- 5
- Pages
- 1661-1661
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3918800
- OpenAlex
- W4254032310
- Cited by
- 52
- References
- 0
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 8 · 2023: 1 · 2022: 7 · 2021: 4 · 2020: 4 · 2019: 6 · 2018: 6 · 2017: 3 · 2016: 8 · 2015: 1 · 2014: 1
- FWCI
- 1.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Veterinary › Small Animals › Animal testing and alternatives
- Keywords
- microbial colonization, host-microbe interactions
- MeSH terms
- Animals, Bacteria, Germ-Free Life, Humans, Viruses, Mice, Host-Pathogen Interactions, Microbiota
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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