The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
IL-6/STAT3 promotes regeneration of airway ciliated cells from basal stem cells
Open accessAbstract
Significance: The airways of the lungs are lined by ciliated and secretory epithelial cells important for mucociliary clearance. When these cells are damaged or lost, they are replaced by the differentiation of basal stem cells. Little is known about how this repair is orchestrated by signaling pathways in the epithelium and underlying stroma. We present evidence using cultured airway cells and genetic manipulation of a mouse model of airway repair that the cytokine IL-6 promotes the differentiation of ciliated vs. secretory cells. This process involves direct Stat3 regulation of genes controlling both cell fate (Notch1) and the differentiation of multiciliated cells (Multicilin and forkhead box protein J1). Moreover, the major producer of IL-6 appears to be mesenchymal cells in the stroma rather than immune cells.
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Self-citationCytokine/Jak/Stat Signaling Mediates Regeneration and Homeostasis in the Drosophila Midgut
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SOCS3 negatively regulates IL-6 signaling in vivo
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Modeling Development and Disease with Organoids
Clevers, H. (2016) · Cell · doi:10.1016/j.cell.2016.05.082 · Cited by 3,196
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Sachs, N., Papaspyropoulos, A., Zomer‐van Ommen, D. D., Heo, I., Böttinger, L., Klay, D., Weeber, F., Huelsz‐Prince, G., Iakobachvili, N., Amatngalim, G. D., et al. (2019) · The EMBO Journal · doi:10.15252/embj.2018100300 · Cited by 1,082
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Metadata
- Authors
- Tadokoro, T., Wang, Y., Barak, L. S., Bai, Y., Randell, S. H., & Hogan, B. L. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2014-08-18
- Volume
- 111
- Issue
- 35
- Pages
- E3641-9
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2150489211
- Cited by
- 288
- References
- 53
- FWCI
- 15.51
- Type
- journal article
- Language
- en
- Open access
- bronze
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