The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Identification of a subpopulation of rapidly self-renewing and multipotential adult stem cells in colonies of human marrow stromal cells
Open accessAbstract
Marrow stromal cells are adult stem cells from bone marrow that can differentiate into multiple nonhematopoietic cell lineages. Previous reports demonstrated that single-cell-derived colonies of marrow stromal cells contained two morphologically distinct cell types: spindle-shaped cells and large flat cells. Here we found that early colonies also contain a third kind of cell: very small round cells that rapidly self-renew. Samples enriched for the small cells had a greater potential for multipotential differentiation than samples enriched for the large cells. Also, the small cells expressed a series of surface epitopes and other proteins that potentially can be used to distinguish the small cells from the large cells. The results suggested it will be important to distinguish the major subpopulations of marrow stromal cells in defining their biology and their potential for cell and gene therapy.
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Cites
Multilineage potential of adult human mesenchymal stem cells
Pittenger, M. F., Mackay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D., Moorman, M. A., Simonetti, D. W., Craig, S., & Marshak, D. R. (1999) · Science · doi:10.1126/science.284.5411.143 · Cited by 21,052
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Marrow Stromal Cells as Stem Cells for Nonhematopoietic Tissues
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Adult rat and human bone marrow stromal cells differentiate into neurons
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Self-citationIn VitroChondrogenesis of Bone Marrow-Derived Mesenchymal Progenitor Cells
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Cited by
Lee, R. H., Pulin, A. A., Seo, M. J., Kota, D. J., Ylostalo, J., Larson, B. L., Semprun-Prieto, L., Delafontaine, P., & Prockop, D. J. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2009.05.003 · Cited by 1,898
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Biologic properties of mesenchymal stem cells derived from bone marrow and adipose tissue
Izadpanah, R., Trygg, C., Patel, B., Kriedt, C., Dufour, J., Gimble, J. M., & Bunnell, B. A. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20904 · Cited by 670
Microfluidics for cell separation
Bhagat, A. A. S., Bow, H., Hou, H. W., Tan, S. J., Han, J., & Lim, C. T. (2010) · Medical & Biological Engineering & Computing · doi:10.1007/s11517-010-0611-4 · Cited by 632
Metadata
- Authors
- Colter, D. C., Sekiya, I., & Prockop, D. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2001-06-26
- Volume
- 98
- Issue
- 14
- Pages
- 7841-7845
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2002320509
- Cited by
- 938
- References
- 32
- FWCI
- 13.03
- Type
- journal article
- Language
- en
- Open access
- green
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- Colter, D. C., Sekiya, I., & Prockop, D. J. (2001). Identification of a subpopulation of rapidly self-renewing and multipotential adult stem cells in colonies of human marrow stromal cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.141221698
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