The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Fibroblasts probe substrate rigidity with filopodia extensions before occupying an area
Open accessAbstract
Significance: Mechanical properties of the extracellular environment provide important cues that regulate cell behavior. Understanding this mechanical signaling has become important in disease treatment as well as tissue engineering. To efficiently study cellular responses to rigidity signals, we have created a model system of micropatterned composite material based on the “cell-on-a-chip” concept. We demonstrate that a migrating fibroblast uses filopodia to probe substrate rigidity, such that it “feels” its way based on the deformability of a material before occupying an area. Myosin II plays a key role in rigidity sensing and responses. This mechanism allows cells to migrate efficiently by avoiding mechanically unfavorable areas without backtracking.
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Cites
Tissue Cells Feel and Respond to the Stiffness of Their Substrate
Discher, D. E., Janmey, P., & Wang, Y.-L. (2005) · Science · doi:10.1126/science.1116995 · Cited by 6,382
Self-citationCell Movement Is Guided by the Rigidity of the Substrate
Lo, C.-M., Wang, H.-B., Dembo, M., & Wang, Y.-L. (2000) · Biophysical Journal · doi:10.1016/s0006-3495(00)76279-5 · Cited by 3,289
Self-citationThe Arp2/3 complex is required for lamellipodia extension and directional fibroblast cell migration
Suraneni, P., Rubinstein, B., Unruh, J. R., Durnin, M., Hanein, D., & Li, R. (2012) · Journal of Cell Biology · doi:10.1083/jcb.201112113 · Cited by 337
Cited by
Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment
Huang, G., Li, F., Zhao, X., Ma, Y., Li, Y., Lin, M., Jin, G., Lu, T. J., Genin, G. M., & Xu, F. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00094 · Cited by 825
Cancer cell motility: lessons from migration in confined spaces
Paul, C. D., Mistriotis, P., & Konstantopoulos, K. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2016.123 · Cited by 648
Janmey, P. A., Fletcher, D. A., & Reinhart-King, C. A. (2020) · Physiological Reviews · doi:10.1152/physrev.00013.2019 · Cited by 422
The interplay of fibroblasts, the extracellular matrix, and inflammation in scar formation
Moretti, L., Stalfort, J., Barker, T. H., & Abebayehu, D. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101530 · Cited by 393
Efremov, A. K., Yao, M., Sun, Y., Tee, Y. H., Sheetz, M. P., Bershadsky, A. D., Martinac, B., & Yan, J. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121477 · Cited by 38
Metadata
- Authors
- Wong, S., Guo, W.-H., & Wang, Y.-L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2014-11-17
- Volume
- 111
- Issue
- 48
- Pages
- 17176-17181
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2021286146
- Cited by
- 167
- References
- 3
- FWCI
- 4.79
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wong, S., Guo, W.-H., & Wang, Y.-L. (2014). Fibroblasts probe substrate rigidity with filopodia extensions before occupying an area. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1412285111
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