The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
A long noncoding RNA connects c-Myc to tumor metabolism
Open accessAbstract
Significance: Long noncoding RNA (lncRNA) has been implicated in carcinogenesis and regarded as an emerging alternative target for cancer therapy. This study provides, to our knowledge, the first case of lncRNA that serves as a coactivator of c-Myc and a master regulator of tumor metabolism. This lncRNA, prostate cancer gene expression marker 1 ( PCGEM1 ), is overexpressed in prostate cancer and implicated in castration resistance. It also forms an independent complex with androgen receptor (AR). Being a dual coactivator for AR and c-Myc, PCGEM1 reprograms the transcriptional network of metabolic genes and androgen-responsive genes, making it an ideal therapeutic target for prostate cancer. The present study provides significant insights into lncRNA’s role in c-Myc activation, tumor metabolism, and prostate carcinogenesis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1160809 · Cited by 16,197
Regulation of cancer cell metabolism
Cairns, R. A., Harris, I. S., & Mak, T. W. (2011) · Nature Reviews Cancer · doi:10.1038/nrc2981 · Cited by 4,744
The landscape of somatic copy-number alteration across human cancers
Beroukhim, R., Mermel, C. H., Porter, D., Wei, G., Raychaudhuri, S., Donovan, J., Barretina, J., Boehm, J. S., Dobson, J., Urashima, M., et al. (2010) · Nature · doi:10.1038/nature08822 · Cited by 4,017
Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate
Ward, P. S., & Thompson, C. B. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.014 · Cited by 3,233
Cited by
The emerging role of lncRNAs in cancer
Huarte, M. (2015) · Nature Medicine · doi:10.1038/nm.3981 · Cited by 2,702
The role of non-coding RNAs in oncology
Slack, F. J., & Chinnaiyan, A. M. (2019) · Cell · doi:10.1016/j.cell.2019.10.017 · Cited by 1,619
Stine, Z. E., Walton, Z. E., Altman, B. J., Hsieh, A. L., & Dang, C. V. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-0507 · Cited by 1,375
Glutaminolysis: A Hallmark of Cancer Metabolism
Yang, L., Venneti, S., & Nagrath, D. (2017) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071516-044546 · Cited by 859
Ren, J., Ding, L., Zhang, D., Shi, G., Xu, Q., Shen, S., Wang, Y., Wang, T., & Hou, Y. (2018) · Theranostics · doi:10.7150/thno.25541 · Cited by 698
Metadata
- Authors
- Hung, C.-L., Wang, L.-Y., Yu, Y.-L., Chen, H.-W., Srivastava, S., Petrovics, G., & Kung, H.-J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2014-12-15
- Volume
- 111
- Issue
- 52
- Pages
- 18697-18702
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2079162697
- Cited by
- 302
- References
- 4
- FWCI
- 7.87
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: A long noncoding RNA connects c-Myc to tumor metabolism. https://app.cochat.ai/papers/10.1073/pnas.1415669112
- The paper
- Hung, C.-L., Wang, L.-Y., Yu, Y.-L., Chen, H.-W., Srivastava, S., Petrovics, G., & Kung, H.-J. (2014). A long noncoding RNA connects c-Myc to tumor metabolism. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1415669112
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
