The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Nitric oxide negatively regulates abscisic acid signaling in guard cells by S-nitrosylation of OST1
Open accessAbstract
Significance: Drought stress induces the accumulation of the plant stress hormone abscisic acid (ABA). ABA then quickly activates the protein kinase OST1/SnRK2.6 to phosphorylate a number of proteins in guard cells, resulting in stomatal closure to reduce transpirational water loss. How SnRK2.6 is deactivated and how ABA signaling may be desensitized are unclear. This study found that nitric oxide (NO) resulting from ABA signaling causes S-nitrosylation of SnRK2.6 at a cysteine residue close to the kinase catalytic site, which blocks the kinase activity. Dysfunction of S-nitrosoglutathione (GSNO) reductase causes GSNO overaccumulation in guard cells and ABA insensitivity in stomatal regulation. This work thus reveals how ABA-induced NO functions in guard cells to inactivate SnRK2.6 to negatively feedback regulate ABA signaling.
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Cites
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
Cross, D. A. E., Alessi, D. R., Cohen, P., Andjelkovich, M., & Hemmings, B. A. (1995) · Nature · doi:10.1038/378785a0 · Cited by 5,244
Cited by
Skubacz, A., Daszkowska-Golec, A., & Szarejko, I. (2016) · Frontiers in Plant Science · doi:10.3389/fpls.2016.01884 · Cited by 499
Nitric oxide and hydrogen sulfide in plants: which comes first?
Corpas, F. J., González-Gordo, S., Cañas, A., & Palma, J. M. (2019) · Journal of Experimental Botany · doi:10.1093/jxb/erz031 · Cited by 253
Metadata
- Authors
- Wang, P., Du, Y., Hou, Y.-J., Zhao, Y., Hsu, C.-C., Yuan, F., Zhu, X., Tao, W. A., Song, C.-P., & Zhu, J.-K.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2014-12-30
- Volume
- 112
- Issue
- 2
- Pages
- 613-618
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1989035935
- Cited by
- 367
- References
- 1
- FWCI
- 30.64
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Nitric oxide negatively regulates abscisic acid signaling in guard cells by S-nitrosylation of OST1. https://app.cochat.ai/papers/10.1073/pnas.1423481112
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- Wang, P., Du, Y., Hou, Y.-J., Zhao, Y., Hsu, C.-C., Yuan, F., Zhu, X., Tao, W. A., Song, C.-P., & Zhu, J.-K. (2015). Nitric oxide negatively regulates abscisic acid signaling in guard cells by S-nitrosylation of OST1. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1423481112
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