The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Evidence for association of schizophrenia with genetic variation in the 8p21.3 gene,PPP3CC, encoding the calcineurin gamma subunit
Open accessAbstract
Schizophrenia is a severe psychiatric disorder characterized by a complex mode of inheritance. Forebrain-specific CNB knockout mice display a spectrum of behavioral abnormalities related to altered behaviors observed in schizophrenia patients. To examine whether calcineurin dysfunction is involved in schizophrenia etiology, we undertook studies of an initial subset of calcineurin-related genes, prioritizing ones that map to loci previously implicated in schizophrenia by linkage studies. Transmission disequilibrium studies in a large sample of affected families detected association of the PPP3CC gene, which encodes the calcineurin γ catalytic subunit, with disease. Our results identify PPP3CC, located at 8p21.3, as a potential schizophrenia susceptibility gene and support the proposal that alterations in calcineurin signaling contribute to schizophrenia pathogenesis.
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Liu, H., Heath, S. C., Sobin, C., Roos, J. L., Galke, B. L., Blundell, M. L., Lenane, M., Robertson, B., Wijsman, E. M., Rapoport, J. L., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.042700699 · Cited by 323
Cited by
The physiology, signaling, and pharmacology of dopamine receptors
Beaulieu, J.-M., & Gainetdinov, R. R. (2011) · Pharmacological Reviews · doi:10.1124/pr.110.002642 · Cited by 2,763
Synaptic Plasticity: Multiple Forms, Functions, and Mechanisms
Citri, A., & Malenka, R. C. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301559 · Cited by 2,323
Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence
Harrison, P. J., & Weinberger, D. R. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001558 · Cited by 2,020
NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders
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Convergent evidence for impaired AKT1-GSK3β signaling in schizophrenia
Emamian, E. S., Hall, D., Birnbaum, M. J., Karayiorgou, M., & Gogos, J. A. (2004) · Nature Genetics · doi:10.1038/ng1296 · Cited by 913
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Metadata
- Authors
- Gerber, D. J., Hall, D., Miyakawa, T., Demars, S., Gogos, J. A., Karayiorgou, M., & Tonegawa, S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2003-07-08
- Volume
- 100
- Issue
- 15
- Pages
- 8993-8998
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2147028713
- Cited by
- 258
- References
- 5
- FWCI
- 12.85
- Type
- journal article
- Language
- en
- Open access
- green
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- Gerber, D. J., Hall, D., Miyakawa, T., Demars, S., Gogos, J. A., Karayiorgou, M., & Tonegawa, S. (2003). Evidence for association of schizophrenia with genetic variation in the 8p21.3 gene,PPP3CC, encoding the calcineurin gamma subunit. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1432927100
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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