The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Therapeutic antitumor immunity by checkpoint blockade is enhanced by ibrutinib, an inhibitor of both BTK and ITK
Open accessAbstract
Significance: Antibodies that block the negative signals between PD1-Ligand on tumor cells and PD-1 on T cells are effective therapies against several types of cancer. Ibrutinib, a covalent inhibitor of BTK is an approved therapy for B-cell leukemia and lymphoma. But ibrutinib also inactivates ITK, an enzyme required for certain subsets of T lymphocytes (Th2 T cells). We found that the combination of anti–PD-L1 antibodies and ibrutinib led to impressive therapeutic effects not only in animal models of lymphoma but, surprisingly, also in models of breast cancer and colon cancer. Based on these preclinical results, we suggest that the combination of PD-1/PD-L1 blockade and ibrutinib be tested broadly in patients with lymphoma and also in other hematologic malignancies and solid tumors.
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Cites
Safety, activity, and immune correlates of anti–PD-1 antibody in cancer
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Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
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PD-1 and Its Ligands in Tolerance and Immunity
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PD-1 Blockade with Nivolumab in Relapsed or Refractory Hodgkin's Lymphoma
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Subsets of Myeloid-Derived Suppressor Cells in Tumor-Bearing Mice
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Self-citationAdvani, R. H., Buggy, J. J., Sharman, J. P., Smith, S. M., Boyd, T. E., Grant, B., Kolibaba, K. S., Furman, R. R., Rodriguez, S., Chang, B. Y., et al. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2012.42.7906 · Cited by 1,128 · cited 3×
“One recent member of this class is ibrutinib, a covalent inhibitor of BTK (Bruton’s tyrosine kinase) (16), a key enzyme in the B-cell receptor signaling pathway and a very effective therapy for chronic lymphocytic leukemia (CLL) Mantle cell lymphoma (MCL) andWaldenstrom’s Macroglobulinemia (17, 18).”
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Cited by
Palucka, A. K., & Coussens, L. M. (2016) · Cell · doi:10.1016/j.cell.2016.01.049 · Cited by 843
Role of Bruton’s tyrosine kinase in B cells and malignancies
Pal Singh, S., Dammeijer, F., & Hendriks, R. W. (2018) · Molecular Cancer · doi:10.1186/s12943-018-0779-z · Cited by 726
Engineered probiotics for local tumor delivery of checkpoint blockade nanobodies
Gurbatri, C. R., Lia, I., Vincent, R., Coker, C., Castro, S., Treuting, P. M., Hinchliffe, T. E., Arpaia, N., & Danino, T. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aax0876 · Cited by 647
Zhong, Y., Ma, Z., Wang, F., Wang, X., Yang, Y., Liu, Y., Zhao, X., Li, J., Du, H., Zhang, M., et al. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0262-4 · Cited by 575
Bruton Tyrosine Kinase–Dependent Immune Cell Cross-talk Drives Pancreas Cancer
Gunderson, A. J., Kaneda, M. M., Tsujikawa, T., Nguyen, A. V., Affara, N. I., Ruffell, B., Gorjestani, S., Liudahl, S. M., Truitt, M., Olson, P., et al. (2016) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-0827 · Cited by 486
Self-citation
Metadata
- Authors
- Sagiv-Barfi, I., Kohrt, H. E. K., Czerwinski, D. K., Ng, P. P., Chang, B. Y., & Levy, R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2015-02-17
- Volume
- 112
- Issue
- 9
- Pages
- E966-72
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2142604595
- Cited by
- 444
- References
- 30
- FWCI
- 19.89
- Type
- journal article
- Language
- en
- Open access
- green
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- Sagiv-Barfi, I., Kohrt, H. E. K., Czerwinski, D. K., Ng, P. P., Chang, B. Y., & Levy, R. (2015). Therapeutic antitumor immunity by checkpoint blockade is enhanced by ibrutinib, an inhibitor of both BTK and ITK. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1500712112
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
