Evolutionary and phenotypic analysis of live virus isolates suggests arthropod origin of a pathogenic RNA virus family
Open accessAbstract
Significance: Knowledge of the origin and evolution of viruses provides important insight into virus emergence involving the acquisition of genes necessary for the infection of new host species or the development of pathogenicity. The family Bunyaviridae contains important arthropod-borne pathogens of humans, animals, and plants. In this study, we provide a comprehensive characterization of two novel lineages of insect-specific bunyaviruses that are in basal phylogenetic relationship to the rodent-borne hantaviruses, the only genus within the Bunyaviridae that is not transmitted by arthropod vectors. These data, together with ancestral state reconstruction of bunyavirus hosts for major virus lineage bifurcations, suggest that the vertebrate-infecting viruses evolved from arthropod-specific progenitors.
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Many extant RNA vertebrate and plant viruses evolved from insect viruses.
“It is becoming clear that many extant RNA vertebrate and plant viruses evolved from insect viruses (Li et al., 2015;Marklewitz et al., 2015).”
From Codon Pair Bias Is a Direct Consequence of Dinucleotide Bias (2016) · cites this paper as Marklewitz et al., 2015
The Discussion says arbo-bunyaviruses likely evolved from arthropod-specific ancestors, and the Significance passage says this includes vertebrate-infecting bunyaviruses. The paper notes that bunyaviruses include plant pathogens, but it does not establish that many plant viruses evolved from insect viruses. Its findings also concern a particular RNA virus family, rather than RNA vertebrate and plant viruses broadly. (LLM, conf=0.84)
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Codon Pair Bias Is a Direct Consequence of Dinucleotide Bias
Kunec, D., & Osterrieder, N. (2016) · Cell Reports · doi:10.1016/j.celrep.2015.12.011 · Cited by 159 · see citing works
“It is becoming clear thatmany extant RNA vertebrate and plant viruses evolved from insect viruses (Li et al., 2015; Marklewitz et al., 2015).”
BackgroundDistinct spread of DNA and RNA viruses among mammals amid prominent role of domestic species
Wells, K., Morand, S., Wardeh, M., & Baylis, M. (2020) · Global Ecology and Biogeography · doi:10.1111/geb.13045 · Cited by 65 · see citing works
- Authors
- Marklewitz, M., Zirkel, F., Kurth, A., Drosten, C., & Junglen, S.
- Affiliations
- University of Bonn (DE)
- Robert Koch Institute (DE)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2015-06-02
- Volume
- 112
- Issue
- 24
- Pages
- 7536-7541
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4475995
- OpenAlex
- W1561863552
- Cited by
- 167
- References
- 0
- Citations by year
- 2026: 9 · 2025: 8 · 2024: 10 · 2023: 7 · 2022: 11 · 2021: 17 · 2020: 12 · 2019: 23 · 2018: 22 · 2017: 22 · 2016: 16 · 2015: 10
- FWCI
- 18.17
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (JU 2857/3-1)
- Deutsches Zentrum für Infektionsforschung (TTU 01.801)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Vectors
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Mosquito-borne diseases and control
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Keywords
- Bunyaviridae, arboviruses, mosquito-borne viruses, RNA-dependent RNA polymerase, cap-snatching, virion morphology, viral evolution, ancestral state reconstruction, orthobunyaviruses, tospoviruses, hantavirus
- MeSH terms
- Amino Acid Sequence, Animals, Arboviruses, Base Sequence, Bunyaviridae, Cell Line, Endonucleases, Microscopy, Electron, Molecular Sequence Data, Culicidae, Phenotype, Phylogeny, RNA-Dependent RNA Polymerase, RNA, Viral, Species Specificity, Temperature, Viral Proteins, Genome, Viral, Conserved Sequence, Sequence Homology, Amino Acid, Evolution, Molecular, Host Specificity
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