The DOI matches its Crossref record.
Human Ebola virus infection results in substantial immune activation
Open accessAbstract
Significance: In 2014, Ebola virus became a household term. The ongoing outbreak in West Africa is the largest Ebola virus outbreak ever recorded, with over 20,000 cases and over 8,000 deaths to date. Very little is known about the human cellular immune response to Ebola virus infection, and this lack of knowledge has hindered development of effective therapies and vaccines. In this study, we characterize the human immune response to Ebola virus infection in four patients. We define the kinetics of T- and B-cell activation, and determine which viral proteins are targets of the Ebola virus-specific T-cell response in humans.
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Cited by
Mathew, D., Giles, J. R., Baxter, A. E., Oldridge, D. A., Greenplate, A. R., Wu, J. E., Alanio, C., Kuri-Cervantes, L., Pampena, M. B., D’Andrea, K., et al. (2020) · Science · doi:10.1126/science.abc8511 · Cited by 1,509
Comprehensive mapping of immune perturbations associated with severe COVID-19
Kuri-Cervantes, L., Pampena, M. B., Meng, W., Rosenfeld, A. M., Ittner, C. A. G., Weisman, A. R., Agyekum, R. S., Mathew, D., Baxter, A. E., Vella, L. A., et al. (2020) · Science Immunology · doi:10.1126/sciimmunol.abd7114 · Cited by 723
Protection against malaria at 1 year and immune correlates following PfSPZ vaccination
Ishizuka, A. S., Lyke, K. E., DeZure, A., Berry, A. A., Richie, T. L., Mendoza, F. H., Enama, M. E., Gordon, I. J., Chang, L.-J., Sarwar, U. N., et al. (2016) · Nature Medicine · doi:10.1038/nm.4110 · Cited by 367
Brainard, J., Pond, K., Hooper, L., Edmunds, K., & Hunter, P. (2016) · PLOS Neglected Tropical Diseases · doi:10.1371/journal.pntd.0004475 · Cited by 65
Metadata
- Authors
- McElroy, A. K., Akondy, R. S., Davis, C. W., Ellebedy, A. H., Mehta, A. K., Kraft, C. S., Lyon, G. M., Ribner, B. S., Varkey, J., Sidney, J., Sette, A., Campbell, S., Ströher, U., Damon, I., Nichol, S. T., Spiropoulou, C. F., & Ahmed, R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2015-03-09
- Volume
- 112
- Issue
- 15
- Pages
- 4719-4724
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2002206719
- Cited by
- 306
- References
- 0
- FWCI
- 25.06
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Human Ebola virus infection results in substantial immune activation. https://app.cochat.ai/papers/10.1073/pnas.1502619112
- The paper
- McElroy, A. K., Akondy, R. S., Davis, C. W., Ellebedy, A. H., Mehta, A. K., Kraft, C. S., Lyon, G. M., Ribner, B. S., Varkey, J., Sidney, J., Sette, A., Campbell, S., Ströher, U., Damon, I., Nichol, S. T., Spiropoulou, C. F., & Ahmed, R. (2015). Human Ebola virus infection results in substantial immune activation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1502619112
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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