The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Immunomodulatory spherical nucleic acids
Open accessAbstract
Significance: We show that by organizing immunomodulatory nucleic acids into spherical nucleic acid (SNA) form, significant increases in activity are observed. Treatment of mice with cancer using immunostimulatory SNAs and nonalcoholic steatohepatitis (NASH) using immunoregulatory SNAs leads to improved disease outcomes vs. their unstructured counterparts. These improvements derive from several key SNA properties, including rapid cellular uptake, endosomal delivery, and multivalent binding. Overall, this work underscores the importance of the spatial orientation and presentation of oligonucleotides in the design of novel immunomodulators.
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Therapeutic potential of Toll-like receptor 9 activation
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Self-citationStructure-based programming of lymph-node targeting in molecular vaccines
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Cited by
The delivery of therapeutic oligonucleotides
Juliano, R. L. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw236 · Cited by 854
Improving cancer immunotherapy through nanotechnology
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Enabling Technologies for Personalized and Precision Medicine
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Metadata
- Authors
- Radovic-Moreno, A. F., Chernyak, N., Mader, C. C., Nallagatla, S., Kang, R. S., Hao, L., Walker, D. A., Halo, T. L., Merkel, T. J., Rische, C. H., Anantatmula, S., Burkhart, M., Mirkin, C. A., & Gryaznov, S. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2015-03-16
- Volume
- 112
- Issue
- 13
- Pages
- 3892-3897
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W4236536513
- Cited by
- 259
- References
- 35
- FWCI
- 8.11
- Type
- journal article
- Language
- en
- Open access
- green
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- Radovic-Moreno, A. F., Chernyak, N., Mader, C. C., Nallagatla, S., Kang, R. S., Hao, L., Walker, D. A., Halo, T. L., Merkel, T. J., Rische, C. H., Anantatmula, S., Burkhart, M., Mirkin, C. A., & Gryaznov, S. M. (2015). Immunomodulatory spherical nucleic acids. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1502850112
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