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The opportunistic marine pathogen Vibrio parahaemolyticus becomes virulent by acquiring a plasmid that expresses a deadly toxin
Open accessAbstract
Significance: Since 2009, an emergent shrimp disease, acute hepatopancreatic necrosis disease (AHPND), has been causing global losses to the shrimp farming industry. The causative agent of AHPND is a specific strain of Vibrio parahaemolyticus . We present evidence here that the opportunistic V. parahaemolyticus becomes highly virulent by acquiring a unique AHPND-associated plasmid. This virulence plasmid, which encodes a binary toxin [ V. parahaemolyticus Photorhabdus insect-related toxins (PirA vp and PirB vp )] that induces cell death, is stably inherited via a postsegregational killing system and disseminated by conjugative transfer. The cytotoxicity of the PirA vp /PirB vp system is analogous to the structurally similar insecticidal pore-forming Cry toxin. These findings will significantly increase our understanding of this emerging disease, which is essential for developing anti-AHPND measures.
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[20] Processing of X-ray diffraction data collected in oscillation mode
Otwinowski, Z., & Minor, W. (1997) · Methods in Enzymology · doi:10.1016/s0076-6879(97)76066-x · Cited by 33,475
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Understanding the role of the shrimp gut microbiome in health and disease
Holt, C. C., Bass, D., Stentiford, G. D., & van der Giezen, M. (2021) · Journal of Invertebrate Pathology · doi:10.1016/j.jip.2020.107387 · Cited by 365
Cornejo-Granados, F., Lopez-Zavala, A. A., Gallardo-Becerra, L., Mendoza-Vargas, A., Sánchez, F., Vichido, R., Brieba, L. G., Viana, M. T., Sotelo-Mundo, R. R., & Ochoa-Leyva, A. (2017) · Scientific Reports · doi:10.1038/s41598-017-11805-w · Cited by 302
Antimicrobial peptides in marine invertebrate health and disease
Destoumieux-Garzón, D., Rosa, R. D., Schmitt, P., Barreto, C., Vidal-Dupiol, J., Mitta, G., Gueguen, Y., & Bachère, E. (2016) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2015.0300 · Cited by 160
Dong, X., Bi, D., Wang, H., Zou, P., Xie, G., Wan, X., Yang, Q., Zhu, Y., Chen, M., Guo, C., et al. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01859 · Cited by 105
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Metadata
- Authors
- Lee, C.-T., Chen, I.-T., Yang, Y.-T., Ko, T.-P., Huang, Y.-T., Huang, J.-Y., Huang, M.-F., Lin, S.-J., Chen, C.-Y., Lin, S.-S., Lightner, D. V., Wang, H.-C., Wang, A. H.-J., Wang, H.-C., Hor, L.-I., & Lo, C.-F.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2015-08-10
- Volume
- 112
- Issue
- 34
- Pages
- 10798-10803
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1897635105
- Cited by
- 611
- References
- 1
- FWCI
- 30.25
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lee, C.-T., Chen, I.-T., Yang, Y.-T., Ko, T.-P., Huang, Y.-T., Huang, J.-Y., Huang, M.-F., Lin, S.-J., Chen, C.-Y., Lin, S.-S., Lightner, D. V., Wang, H.-C., Wang, A. H.-J., Wang, H.-C., Hor, L.-I., & Lo, C.-F. (2015). The opportunistic marine pathogen Vibrio parahaemolyticus becomes virulent by acquiring a plasmid that expresses a deadly toxin. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1503129112
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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